Protein

MCA_03747_1

Length
705 amino acids

Gene name: ILV2

Description: Acetolactate synthase catalytic subunit, mitochondrial

Browser: contigC:962588-965089+

RNA-seq: read pairs 2770, FPKM 48.5, percentile rank 64.7% (100% = highest expression)

Protein function

Annotation:ILV2Acetolactate synthase catalytic subunit, mitochondrial
KEGG:K01652E2.2.1.6L acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
EGGNOG:0PFW3ILV2Acetolactate synthase
SGD closest match:S000004714ILV2Acetolactate synthase catalytic subunit, mitochondrial
CGD closest match:CAL0000198378ILV2Acetolactate synthase

Protein alignments

%idAln lengthE-value
MIA_03343_183.02%6890.0MIA_03343_1
A0A0J9XDD8_GEOCN79.51%6880.0Acetolactate synthase OS=Geotrichum candidum GN=BN980_GECA11s00197g PE=3 SV=1
A0A060T3D1_BLAAD69.88%6940.0Acetolactate synthase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36410g PE=3 SV=1
A0A167CYS7_9ASCO75.66%6040.0Acetolactate synthase OS=Sugiyamaella lignohabitans GN=ILV2 PE=3 SV=1
Q6CDI5_YARLI69.58%6640.0Acetolactate synthase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C00253g PE=3 SV=1
A0A1D8PJF9_CANAL66.77%6650.0Acetolactate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ILV2 PE=3 SV=1
UniRef50_A3LUG668.02%6630.0Acetolactate synthase n=300 Tax=Fungi TaxID=4751 RepID=A3LUG6_PICST
A0A1E4TAW9_9ASCO66.81%6780.0Acetolactate synthase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32297 PE=3 SV=1
A0A1E3PEA0_9ASCO69.11%6540.0Acetolactate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48073 PE=3 SV=1
ILVB_YEAST68.20%6290.0Acetolactate synthase catalytic subunit, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9987
Predicted cleavage: 48

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 705

Detailed signature matches

  1. Family IPR012846
    Acetolactate synthase, large subunit, biosynthetic
    1. TIGR00118
  2. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  3. Domain IPR012001
    Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
    1. PF02776 (TPP_enzyme_N)
  4. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  5. Domain IPR012000
    Thiamine pyrophosphate enzyme, central domain
    1. PF00205 (TPP_enzyme_M)
  6. Domain IPR011766
    Thiamine pyrophosphate enzyme, C-terminal TPP-binding
    1. PF02775 (TPP_enzyme_C)
  7. SITE IPR000399
    TPP-binding enzyme, conserved site
    1. PS00187 (TPP_ENZYMES)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd02015 (TPP_AHAS)
  4. cd07035 (TPP_PYR_PO...)

Residue annotation

  1. PYR/PP interface c...
  2. TPP binding site c...
  3. dimer interface cd...
  4. TPP-binding site c...
  5. dimer interface cd...

Protein sequence

>MCA_03747_1
MLRATLPTRSASKRAFSKVVSNAFAANTIKSTPSVFFRHISNTSKNSSEAAAQTVTRPEPAPSFNTIDTTNEPSRLKQKS
NTAMDDSFIGLTGGQIFHEMMLRHNVDTIFGYSGGAILPVFDGIYNSPHFKFIMPRHEQGAGHMAEGYAKATGKPGVVVV
TSGPGATNVITPMQDALSDGIPMVVFTGQVATGAIGTDAFQEADVVGISRSCTKWNVMVKNINELPRRINEAFEIATSGR
PGPVLVDLPKDVTSAVLRESIPTHATIPSQSLQNLAATAVSEFQKESIERAAALINNAKKPVIYAGNGIMNSEEGPVFLR
ELANKAQIPVTTTLHGLGAFDETDPKALRMLGMHGSGSANMAMQQADVIIALGARFDERVTGNITKFAPAARLAALEKRG
GIIHFEILPKNINKVVEATEAVEGDVAQNLAKLLPLIKPVKERPEWLGQVAEWKAKYPFDYLKDTPGSGEAVKPQTVITK
LSELTENVKDRVIMTTGVGQHQMWAAQHFKFKYPRSMISSGGLGTMGFGLPAAIGAKVGSPESIVVDIDGDASFNMTLAE
LSCAVQYGINVKIIVLNNEEQGMVTQWQSLFYDNRFSHTHQKNPDFMKLAEAMGLKGIRIKTFEELEPGLKEMLEYNDGP
VLVEVFVDKKVPVLPMIAAGKGLDEFLVYNEEVENERQKLRLEHAERQLKKAQADAAHWAATVQK

GO term prediction

Biological Process

GO:0009082 branched-chain amino acid biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0003984 acetolactate synthase activity
GO:0030976 thiamine pyrophosphate binding
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.