MCA_03697_1

Protein

Length

1,223 amino acids

Gene name: MPS1

Description: Dual specificity protein kinase Mps1; in S. cerevisiae a dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function

Browser: contigC:800919-804591+

RNA-seq: read pairs 5544, FPKM 56.0, percentile rank 67.9% (100% = highest expression)

Protein function

Annotation:		MPS1	Dual specificity protein kinase Mps1; in S. cerevisiae a dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function
KEGG:	K08866	TTK	serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]
EGGNOG:	0PHX5	MPS1	Checkpoint protein kinase
SGD closest match:	S000002186	MPS1	Serine/threonine-protein kinase MPS1
CGD closest match:	CAL0000200652	MPS1	Serine/threonine/tyrosine protein kinase

Protein alignments

	%id	Aln length	E-value
MIA_00577_1	73.04%	382	0.0	MIA_00577_1
A0A0J9XGR1_GEOCN	74.87%	394	0.0	Similar to Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function OS=Geotrichum candidum GN=BN980_GECA16s02276g PE=4 SV=1
UniRef50_A0A0J9XGR1	74.87%	394	0.0	Similar to Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGR1_GEOCN
A0A167BZ37_9ASCO	61.94%	381	1e-161	Serine/threonine/tyrosine protein kinase MPS1 OS=Sugiyamaella lignohabitans GN=MPS1 PE=4 SV=1
A0A1E3PN36_9ASCO	58.79%	364	5e-145	Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_23219 PE=3 SV=1
Q6C2I8_YARLI	57.46%	362	3e-132	YALI0F07557p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F07557g PE=4 SV=1
A0A060T6M1_BLAAD	56.04%	364	2e-133	ARAD1B19998p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B19998g PE=4 SV=1
MPS1_YEAST	46.52%	374	3e-112	Serine/threonine-protein kinase MPS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MPS1 PE=1 SV=2
A0A1D8PTW7_CANAL	45.08%	386	5e-100	Serine/threonine/tyrosine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MPS1 PE=4 SV=1
A0A1E4THF8_9ASCO	47.32%	298	4e-88	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57461 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0809
Predicted cleavage: 51

Protein family membership

None predicted.

Domains and repeats

Domain
852 - 1,171
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 200 400 600 800 1000 1223

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,087 - 1,171
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  852 - 1,040
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  860 - 1,168
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  860 - 1,037
  
  Pfam
  PF00069 (Pkinase)
  
  1,083 - 1,167
  
  Pfam
  PF00069 (Pkinase)
3. SM00220 (serkin_6)
  
  860 - 1,168
  
  SMART
  SM00220 (serkin_6)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  866 - 888
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  980 - 992
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

Coil

739 - 759

COILS
Coil (Coil)

763 - 813

COILS
Coil (Coil)
G3DSA:1.10.51...

926 - 1,179

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:1.20.10...

630 - 843

GENE3D
G3DSA:1.20.1000.10 (G3DSA:1.20.1000.10)
G3DSA:3.30.20...

844 - 925

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd14131 (PKc_Mps1)

858 - 1,168

CDD
cd14131 (PKc_Mps1)
mobidb-lite (disord...)

1,043 - 1,082

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 78

MobiDB Lite
mobidb-lite (disorder_prediction)

644 - 739

MobiDB Lite
mobidb-lite (disorder_prediction)

820 - 849

MobiDB Lite
mobidb-lite (disorder_prediction)

92 - 194

MobiDB Lite
mobidb-lite (disorder_prediction)

242 - 629

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

866I

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

867G

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

868R

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

869G

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

870G

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

874V

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

886A

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

888K

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

921V

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

937M

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

938E

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

939C

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

940G

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

943D

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

984D

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

986K

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

988A

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

989N

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

991L

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)

1,001D

ATP binding site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 984D, 986K, 988A, 989N, 991L, 1,001D
CDD
cd14131 (PKc_Mps1)
active site cd14131

866I

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

867G

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

868R

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

869G

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

870G

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

874V

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

886A

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

888K

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

921V

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

937M

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

938E

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

939C

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

940G

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

943D

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

945A

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

984D

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

986K

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

988A

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

989N

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

991L

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,001D

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,004I

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,022G

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,023T

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,024L

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,025N

active site
866I, 867G, 868R, 869G, 870G, 874V, 886A, 888K, 921V, 937M, 938E, 939C, 940G, 943D, 945A, 984D, 986K, 988A, 989N, 991L, 1,001D, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)
polypeptide substr...

870G

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

943D

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

945A

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

984D

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

986K

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

988A

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,004I

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,022G

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,023T

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,024L

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,025N

polypeptide substrate binding site
870G, 943D, 945A, 984D, 986K, 988A, 1,004I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)
secondary chemical...

872S

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)

888K

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)

890V

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)

904F

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)

907E

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)

935V

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)

1,000I

secondary chemical binding site
872S, 888K, 890V, 904F, 907E, 935V, 1,000I
CDD
cd14131 (PKc_Mps1)
activation loop (A...

1,000I

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,001D

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,002F

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,003G

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,004I

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,005A

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,006N

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,007V

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,008V

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,009P

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,010D

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,011Y

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,012T

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,013S

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,014N

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,015V

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,016H

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,017R

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,018D

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,019T

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,020Q

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,021I

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,022G

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,023T

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,024L

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

1,025N

activation loop (A-loop)
1,000I, 1,001D, 1,002F, 1,003G, 1,004I, 1,005A, 1,006N, 1,007V, 1,008V, 1,009P, 1,010D, 1,011Y, 1,012T, 1,013S, 1,014N, 1,015V, 1,016H, 1,017R, 1,018D, 1,019T, 1,020Q, 1,021I, 1,022G, 1,023T, 1,024L, 1,025N
CDD
cd14131 (PKc_Mps1)

Protein sequence

>MCA_03697_1
MYSQYSSKVDRGTQQPHVLNGILESSLASSTSGSGNQNNNNLPFTGSVRPRTLREQISTEDDDVDSVSSSEGSCKPPVLS
EYGSVLLSENIMQSSKPKQSKLSALKSRISNSNSNSSSSIAPSVPLKTTASVPSLSTTSVNSNIQGNNLTHPTSSSNSNS
PSTIAAVTTPPASSSANNSNNNSNNSIPLASSNSNSSLRLGNSYPHLHLHPYHGSYQVPSPINGSRQQHEIKRHLNRVKL
EQRLSHSDSNENENSPGLGSGRLRHYSSTGSNNSFRSTDDEAHNSHINNSNNNNNHTSGSIGSNNGQKLSGSASPESSVR
LNRSTGSLRPTPSYDSQLGGIESSPPEQGPPPISHLSNQHSQSNSSLHSNEPPSSVHSGFPLQYLPHHSHSHSHSHSQIQ
SKSSDSLANSSSFISHNHSQSQSYSQSTENSPPLSHGFPTSTARAINPDHASATASQSNSSSSTNIPNPIPIPQKQTLPP
SKTGSSTYGTASQEHNPSYSFSTPGINKQQQQPNSRLMFSETSRTGTARAKRFGRGLGPPMRITRRESDENPSNTVVSAG
LENHINEDERGKSTRISEYLKNGSSSLANSNANYETSSDRDNSSHGAANFSNRENTPDFPFNSEQPPKPAELHQAYKNEM
DNYDSLQQSQKNETPKPSASIQSFSSNTDSNEAPSGPPIETIPTTLENNDNKNEEDIPSENVEENPPTPLAPIDLASILQ
QHQNIQAQNGNPQDRQMSREALEDKMEREMTLERQHEELKHYLHIQEQLIQQQQQQLQQQQQLQELQQQEKLKAEAEAKA
QQKAEAEAKAQQRAEAAAAAAAAQAQAQQQAQAKSHSHEQARQSSSRKKSNIIYVNSKPYQRLEMIGRGGSSKVYKAQAT
TGKVYAIKRVSCDEDMDDNVLKGFKGEIDLLQRLKDEDRVVKLIDFELRESSIYVVMECGEIDLAYVLSARLNQPLDISF
VRYYATEMFHCVEAVHRHEIVHSDLKPANFLLVKGMLKIIDFGIANVVPDYTSNVHRDTQIGTLNYMAPEALLDVSHGYA
NNARNGESANNNDNLRKNNRNSIQNVNSLNPTPQKPRTTKFKVGKPSDVWSCGCIIYQMIYGRPPYGTYQGTQRMLAIMN
PKVPIEYYPQGLGNVRVPKEAIETIKGCLDRDPTQRLTINQIMNGAFLNPQAVDRRFIHDLLGHAVRYGAERGNKVTAEE
LKLLTDSVWKKIQASNQTYNGSS

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component