Protein

MCA_03571_1

Length
666 amino acids

Gene name: UBA2

Description: Ubiquitin-activating enzyme E1-like

Browser: contigC:378003-380124+

RNA-seq: read pairs 1445, FPKM 26.8, percentile rank 49.5% (100% = highest expression)

Protein function

Annotation:UBA2Ubiquitin-activating enzyme E1-like
KEGG:K10685UBLE1B ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
EGGNOG:0PFVAUBA2Ubiquitin-activating enzyme
SGD closest match:S000002798UBA2Ubiquitin-activating enzyme E1-like
CGD closest match:CAL0000174476UBA2E1 ubiquitin-activating protein

Protein alignments

%idAln lengthE-value
MIA_03798_158.41%6420.0MIA_03798_1
A0A0J9XK53_GEOCN55.59%5720.0Similar to Saccharomyces cerevisiae YDR390C UBA2 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p OS=Geotrichum candidum GN=BN980_GECA24s00384g PE=4 SV=1
UniRef50_A0A177CY4646.55%5955e-170Ubiquitin-activating enzyme E1 3 n=2 Tax=leotiomyceta TaxID=716546 RepID=A0A177CY46_9PLEO
A0A060T2V8_BLAAD48.54%5485e-168ARAD1A03784p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03784g PE=4 SV=1
A0A1E3PSK9_9ASCO48.24%5683e-164Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68648 PE=4 SV=1
A0A1E4TC97_9ASCO45.78%5575e-160Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20431 PE=4 SV=1
Q6CA35_YARLI44.91%5793e-144YALI0D06259p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06259g PE=4 SV=1
A0A167C8D8_9ASCO45.63%4695e-131E1 ubiquitin-activating protein UBA2 OS=Sugiyamaella lignohabitans GN=UBA2 PE=4 SV=1
A0A1D8PE77_CANAL41.42%5772e-126E1 ubiquitin-activating protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UBA2 PE=4 SV=1
UBA2_YEAST39.79%5832e-124Ubiquitin-activating enzyme E1-like OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBA2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0104

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 666

Detailed signature matches

  1. Family IPR030661
    SUMO-activating enzyme subunit Uba2
    1. PIRSF039133 (SUMO_E1B)
  2. Domain IPR000594
    THIF-type NAD/FAD binding fold
    1. PF00899 (ThiF)
    2. SSF69572 (Activatin...)
  3. Domain IPR019572
    Ubiquitin-activating enzyme, catalytic cysteine domain
    1. PF10585 (UBA_e1_thi...)
  4. Domain IPR028077
    Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    1. PF14732 (UAE_UbL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.10.29...
  3. G3DSA:3.40.50...
  4. mobidb-lite (disord...)

Protein sequence

>MCA_03571_1
MTGELDSGRYQNSIQALGSTTFEKIKNAKVLMVGAGGIGCEILKNLVLLGVGEIHIVDLDTIDLSNLNRQFLFSHEHIKQ
PKALVAAQTASKFNPNVKIVPHYSDIKNTTLFPLEWFQSFDLYYNALDNKDARSYVNRMALTANVPLIESGTAGYKGQTL
VISNGKTECFECVPKAQPKSFAVCTIRSTPSQPVHTIVWAKNFLFSQLFGPEEESLASTESLDENPDDETDEKEKEEQRQ
LANELHALRSNLKEEDFARKIFDKIFTEDIANLASMETMWKLRKAPTPLNYEDIVEQITKLDPDTDNSEEAVLRLAKKTA
KLEQKDWDMFETFSVFYDSVRRLKERALAENEEGKVTYLSFDKDDEDTLDFVVSAAQLRAYIFHIQTKSKFDYKQIAGNI
IPAIATTNAVIAGMSVLQSIKILASLDIKPKSSSSEKEEKVNNTKKTALSDEVLKKCPTVFLAMNPTHIFSTESVSKPNP
RCVVCGVSRAVLPVDPAKTKLRDIVETLLDKNWNYSNEVSVLVPTGLIYDPDYDDNLDKTLTELGVTSNSYLTIIDELDE
HEDGDSTVGARQNLELFIVTDNKQSEKSSEEILKELEPVEFKTKLPKEEKEEEADTSTTGMKRKLESSPDDPNESSKKLK
ISENEDGNEVIEFDEDDEEDELIEID

GO term prediction

Biological Process

GO:0016925 protein sumoylation

Molecular Function

GO:0008641 small protein activating enzyme activity
GO:0019948 SUMO activating enzyme activity

Cellular Component

None predicted.