Protein

MCA_03499_1

Length
957 amino acids

Gene name: MSH4

Description: MutS protein homolog 4

Browser: contigC:130155-133925+

RNA-seq: read pairs 243, FPKM 3.1, percentile rank 13.9% (100% = highest expression)

Protein function

Annotation:MSH4MutS protein homolog 4
KEGG:K08740MSH4 DNA mismatch repair protein MSH4
EGGNOG:0PIRBMSH4DNA mismatch repair protein
SGD closest match:S000001891MSH4MutS protein homolog 4
CGD closest match:CAL0000197996CAALFM_CR01790CAMutS family protein

Protein alignments

%idAln lengthE-value
MIA_02875_153.32%8140.0MIA_02875_1
A0A0J9XHT0_GEOCN39.64%10140.0Similar to Saccharomyces cerevisiae YFL003C MSH4 Protein involved in meiotic recombination OS=Geotrichum candidum GN=BN980_GECA17s01539g PE=4 SV=1
UniRef50_A0A0J9XHT039.64%10140.0Similar to Saccharomyces cerevisiae YFL003C MSH4 Protein involved in meiotic recombination n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHT0_GEOCN
MSH4_YEAST35.24%7694e-141MutS protein homolog 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH4 PE=1 SV=2
A0A1D8PS25_CANAL32.71%7008e-104MutS family protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR01790CA PE=4 SV=1
A0A060TBS9_BLAAD25.60%7073e-39ARAD1B17798p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B17798g PE=3 SV=1
A0A167DCW4_9ASCO24.79%7143e-39Mismatch repair ATPase MSH2 OS=Sugiyamaella lignohabitans GN=MSH2 PE=3 SV=1
A0A1E4TE51_9ASCO24.49%7315e-36Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31131 PE=3 SV=1
A0A1E3PQS8_9ASCO23.84%6252e-34DNA mismatch repair protein msh-2 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69419 PE=3 SV=1
Q6C3F6_YARLI23.55%7053e-34YALI0F00154p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F00154g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0203

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 957

Detailed signature matches

  1. Family IPR011184
    DNA mismatch repair Msh2-type
    1. PIRSF005813 (MSH2)
  2. Domain IPR007860
    DNA mismatch repair protein MutS, connector domain
    1. G3DSA:3.30.42...
    2. PF05188 (MutS_II)
  3. Domain IPR007696
    DNA mismatch repair protein MutS, core
    1. SM00533 (DNAend)
    2. SSF48334 (DNA repai...)
    3. PF05192 (MutS_III)
  4. Domain IPR007861
    DNA mismatch repair protein MutS, clamp
    1. PF05190 (MutS_IV)
  5. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  6. Domain IPR000432
    DNA mismatch repair protein MutS, C-terminal
    1. PF00488 (MutS_V)
    2. SM00534 (mutATP5)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.14...
  2. G3DSA:3.40.50...
  3. mobidb-lite (disord...)

Protein sequence

>MCA_03499_1
MSKKNQSFEGESYIKSFVGDAYTVNPPSSRRNTGNESRAISRSKAVSLGPTADQIICTIAEGRGVATVVGICFLIPSTCE
MILCHIVDSQTYIRTLQKLDVFDPTEIIFPITSSVPNKSKLFLLVEEFFPGSKFIQASRRSFSEEADRNLILQYAFASEK
EALAYELSDDKYYMISAASAMLQYIKSKYSSFFDFNKLRIKIQSSEDSMIISTRTLKSLEVINNSIDKSNGPSLFKVMNF
TKTSMGARVLRSNLVQPLTNLSSILRRHEALEELCNDMPSVKECQAQLTHFEDLDKLLTSMSVILKKKNESNSSTGKSDH
RVNQVIMLKEAISASLMIADILKGFKSPMLIELKDLLEGEVVREVQEMIMDYINPEIRWARNSQELRNQRNNAVKAGANG
FLDAARDVFNEYTRDTFETCKSYGQTYGINPSCVYDSKRGYFLRIAITEKEELDKLPENIFVNRKRNKKYLECTTLDLMK
CNTRLKSITSEITMISDQILDELFDKLNEAIFPLFMVSEAVSVLDLLCSFATLVTSSTAGYVKPVFTTDHTEETGVIGGN
QILNSGKLALKQSRHPVLDRIMKYKPFIPNDIYAAQDTSRMNIITGVNMSGKSVYLRQIALLAIMAQTGCFIPAEFARMP
IYRALYARISNDPDDDMLKSSFTAEMTEIAYILHHVKEPCSKDCNVGIWSELIIIDELGRGSSVADGLAVSLAIADWLVR
QSFTDEEMPRAEGTIYRLSNDALKRRKIAGGTRKAVTTFMSTHFHDLAKAMGMRPGVSIINMRADIQQMGMTMHYKATKT
SSDNMDDLLYGNDKQQQVSPDKDSNNNSSNRLYYGLMLAKSLPFPQKFIDLAYENRNILQENENRQTLLNEKGSITEAAA
TTIDETSTTTSTTTKLVGPAQLWRQKKKITDLYEALVHIDEIYYENDTESDDQVKKWLLFLQNQFINVMDDINNGKS

GO term prediction

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

Cellular Component

None predicted.