Protein

MCA_03481_1

Length
663 amino acids

Gene name: PTC5

Description: Mitochondrial type 2C protein phosphatase (PP2C)

Browser: contigC:81823-83815-

RNA-seq: read pairs 4077, FPKM 75.9, percentile rank 74.3% (100% = highest expression)

Protein function

Annotation:PTC5Mitochondrial type 2C protein phosphatase (PP2C)
KEGG:K01102PDP pyruvate dehydrogenase phosphatase [EC:3.1.3.43]
EGGNOG:0PFV7PGUG_01950phophatase 2C family protein
SGD closest match:S000005616PTC5[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
CGD closest match:CAL0000200868PTC5Type 2C protein phosphatase

Protein alignments

%idAln lengthE-value
MIA_04186_173.55%5860.0MIA_04186_1
A0A0J9X9Y6_GEOCN61.13%5660.0Similar to Saccharomyces cerevisiae YOR090C PTC5 Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity OS=Geotrichum candidum GN=BN980_GECA06s03475g PE=4 SV=1
A0A167ED17_9ASCO59.08%5450.0Type 2C protein phosphatase PTC5 OS=Sugiyamaella lignohabitans GN=PTC5 PE=4 SV=1
UniRef50_A0A167ED1759.08%5450.0Type 2C protein phosphatase PTC5 n=6 Tax=Saccharomycetales TaxID=4892 RepID=A0A167ED17_9ASCO
A0A060TBI9_BLAAD55.54%5600.0ARAD1B16082p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B16082g PE=4 SV=1
Q6C9Z9_YARLI46.41%6555e-177YALI0D07040p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D07040g PE=4 SV=1
A0A1E3PK11_9ASCO50.00%5605e-171Protein serine/threonine phosphatase 2C OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83303 PE=4 SV=1
A0A1E4TFL5_9ASCO50.59%5083e-165Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17420 PE=4 SV=1
Q5A388_CANAL45.86%5801e-157Type 2C protein phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PTC5 PE=3 SV=1
PDP1_YEAST38.07%6126e-116[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9784
Predicted cleavage: 173

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 663

Detailed signature matches

  1. Domain IPR001932
    PPM-type phosphatase domain
    1. SM00332 (PP2C_4)
    2. G3DSA:3.60.40.10
    3. PF00481 (PP2C)
    4. SSF81606 (PP2C-like)
    5. PS51746 (PPM_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TRANSMEMBRANE (Tran...)
  4. cd00143 (PP2Cc)

Residue annotation

  1. Active site cd00143

Protein sequence

>MCA_03481_1
MLKVSSKSKLCLPQRTLFQNSTVRSISGSLSKFHTLQSSTNTLRHLSSKPNHHLSKITSAYNTHAYPFITTNSSLVTSRN
NYSTRILNSTSSFFGPNQRWKSVAVVATSILLAGSYLTFKPRSIALESPFSSASPFGLPRSSAHQNKEPITMMTPVQVSA
RLRELEESYFVDRGKGVIRYDVSQLPSNSPIEDDRSEKIVQVPLISDSKDGVSDESKGSAKDNSQNAINSQLNHFSSDWM
FWGVYDGHSGWTTSAKLRDALIAYVLSELDKAYVKSSKDSIYRIVPSPNAIDTAIQQGFLKLDNDIVHQSVERLMANPDK
AGAAEHIAPALSGSCGILAFYDTHSKDLRVAVTGDSRAVLGSLNDKGEWTARALSVDQTGSNPDEAARLRKEHPGEEDTV
VRRGRVLGNLEPTRAFGDARYKWTREVQEKMVRYFFGRRVPSDFRTPPYVTAKPEVTTTKINPQNGDFLVLGTDGLYEML
TNEEIVGLVVQWLNVKKPEYFSSVSETIKQRSSGKHLWSRLFGGSSSSSDVSTADTGLNGNKRKPVVIKAEHSDLAVTVK
DLSSNPESQKQVIGRQPGVIPRFTVEDDNIATHLMRNALGGADIQQVSMLVSIPAPISRSYRDDLTVTVVLFGNQGPEND
AGAVRVNEDATRKTLKTHVKAKM

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.