MCA_03350_1

Protein

Length

1,332 amino acids

Gene name: IRE1

Description: Serine/threonine-protein kinase/endoribonuclease Ire1; in S. cerevisiae mediates the unfolded protein response (UPR)

Browser: contigB:4123709-4127867+

RNA-seq: read pairs 1963, FPKM 18.2, percentile rank 38.8% (100% = highest expression)

Protein function

Annotation:		IRE1	Serine/threonine-protein kinase/endoribonuclease Ire1; in S. cerevisiae mediates the unfolded protein response (UPR)
KEGG:	K08852	ERN1	serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
EGGNOG:	0PFXN	IRE1	protein kinase and ribonuclease Ire1
SGD closest match:	S000001121	IRE1	Serine/threonine-protein kinase/endoribonuclease IRE1
CGD closest match:	CAL0000181249	IRE1	Bifunctional endoribonuclease/protein kinase

Protein alignments

	%id	Aln length	E-value
A0A0J9XES8_GEOCN	63.32%	518	0.0	Similar to Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease OS=Geotrichum candidum GN=BN980_GECA12s02573g PE=4 SV=1
UniRef50_A0A0J9XES8	63.32%	518	0.0	Similar to Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XES8_GEOCN
MIA_01774_1	62.01%	537	0.0	MIA_01774_1
A0A1E3PDA1_9ASCO	64.17%	480	0.0	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84511 PE=4 SV=1
W0TYQ2_YARLI	56.66%	473	3e-165	YALI0A14839p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A14839g PE=4 SV=1
A0A167FU59_9ASCO	56.87%	473	2e-156	Bifunctional endoribonuclease/protein kinase IRE1 OS=Sugiyamaella lignohabitans GN=IRE1 PE=4 SV=1
A0A1D8PE76_CANAL	53.57%	476	1e-145	Bifunctional endoribonuclease/protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IRE1 PE=4 SV=1
A0A060T7Y2_BLAAD	54.81%	447	2e-144	ARAD1C31724p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31724g PE=4 SV=1
A0A1E4TCS0_9ASCO	52.40%	458	8e-141	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_140799 PE=4 SV=1
IRE1_YEAST	49.90%	481	7e-134	Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRE1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3057
Predicted cleavage: 40

Protein family membership

None predicted.

Domains and repeats

Domain
134 - 292
Quinoprotein alcohol dehydrogenase-like superfamily (IPR011047)
360 - 425
Quinoprotein alcohol dehydrogenase-like superfamily (IPR011047)
861 - 1,201
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
1,258 - 1,312
PUB domain (IPR018997)
Domain
1,196 - 1,328
KEN domain (IPR010513)
Repeat
162 - 193
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)
262 - 293
Pyrrolo-quinoline quinone beta-propeller repeat (IPR018391)

1 200 400 600 800 1000 1200 1332

Detailed signature matches

IPR011047

Quinoprotein alcohol dehydrogenase-like superfamily
1. SSF50998 (Quinoprot...)
  
  134 - 292
  
  SUPERFAMILY
  SSF50998 (Quinoprotein alcohol dehydrogenase-like)
  
  360 - 425
  
  SUPERFAMILY
  SSF50998 (Quinoprotein alcohol dehydrogenase-like)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  865 - 991
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,105 - 1,201
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,022 - 1,064
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  861 - 1,193
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. SM00220 (serkin_6)
  
  861 - 1,193
  
  SMART
  SM00220 (serkin_6)
3. PF00069 (Pkinase)
  
  1,101 - 1,193
  
  Pfam
  PF00069 (Pkinase)
  
  864 - 1,067
  
  Pfam
  PF00069 (Pkinase)
IPR010513

KEN domain
1. PS51392 (KEN)
  
  1,196 - 1,328
  
  PROSITE profiles
  PS51392 (KEN)
2. PF06479 (Ribonuc_2-5A)
  
  1,199 - 1,325
  
  Pfam
  PF06479 (Ribonuc_2-5A)
IPR018997

PUB domain
1. SM00580 (PGNneu)
  
  1,258 - 1,312
  
  SMART
  SM00580 (PGNneu)
IPR018391

Pyrrolo-quinoline quinone beta-propeller repeat
1. SM00564 (ire1_9)
  
  162 - 193
  
  SMART
  SM00564 (ire1_9)
  
  262 - 293
  
  SMART
  SM00564 (ire1_9)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  979 - 991
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

50 - 641

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

1,329 - 1,332

COILS
Coil (Coil)
G3DSA:1.10.51...

974 - 1,202

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:2.140.1...

55 - 599

GENE3D
G3DSA:2.140.10.10 (G3DSA:2.140.10.10)
G3DSA:3.30.20...

693 - 973

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
NON_CYTOPLASM... (N...)

1 - 26

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

662 - 1,332

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

27 - 49

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

642 - 661

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

27 - 49

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd10422 (RNase_Ire1)

1,198 - 1,326

CDD
cd10422 (RNase_Ire1)
cd13982 (STKc_IRE1)

859 - 1,194

CDD
cd13982 (STKc_IRE1)
mobidb-lite (disord...)

995 - 1,018

MobiDB Lite
mobidb-lite (disorder_prediction)

704 - 807

MobiDB Lite
mobidb-lite (disorder_prediction)

305 - 342

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface (b...

859S

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

881F

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

882E

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

884R

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

907Q

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

908E

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

910D

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

912H

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

917R

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

918Y

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

919Y

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

920C

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

921K

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

933E

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

969S

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

972Q

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

973H

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

976S

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

977L

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

1,026R

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

1,185S

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)

1,188L

dimer interface (back-to-back)
859S, 881F, 882E, 884R, 907Q, 908E, 910D, 912H, 917R, 918Y, 919Y, 920C, 921K, 933E, 969S, 972Q, 973H, 976S, 977L, 1,026R, 1,185S, 1,188L
CDD
cd13982 (STKc_IRE1)
oligomer interface...

865E

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

878K

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,043S

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,044S

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,111R

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,155P

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,156E

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,157T

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)

1,183E

oligomer interface
865E, 878K, 1,043S, 1,044S, 1,111R, 1,155P, 1,156E, 1,157T, 1,183E
CDD
cd13982 (STKc_IRE1)
ATP binding site c...

867L

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

868G

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

869Y

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

870G

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

871S

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

874T

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

876V

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

887A

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

889K

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

916I

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

932L

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

933E

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

935C

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

938T

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

987Q

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

988N

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

990L

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)

1,031D

ATP binding site
867L, 868G, 869Y, 870G, 871S, 874T, 876V, 887A, 889K, 916I, 932L, 933E, 935C, 938T, 987Q, 988N, 990L, 1,031D
CDD
cd13982 (STKc_IRE1)
active site cd13982

867L

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

868G

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

869Y

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

870G

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

871S

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

876V

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

887A

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

889K

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

916I

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

932L

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

933E

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

934L

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

935C

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

938T

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

940E

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

983D

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

985K

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

987Q

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

988N

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

990L

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,031D

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,034L

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,054G

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,055T

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,056S

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,057G

active site
867L, 868G, 869Y, 870G, 871S, 876V, 887A, 889K, 916I, 932L, 933E, 934L, 935C, 938T, 940E, 983D, 985K, 987Q, 988N, 990L, 1,031D, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)
dimer interface (f...

869Y

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

872H

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

873G

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

875V

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

890R

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

892L

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

924T

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

926R

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

927F

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

1,137I

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

1,138L

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

1,140E

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

1,141A

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)

1,144V

dimer interface (face-to-face)
869Y, 872H, 873G, 875V, 890R, 892L, 924T, 926R, 927F, 1,137I, 1,138L, 1,140E, 1,141A, 1,144V
CDD
cd13982 (STKc_IRE1)
polypeptide substr...

871S

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

938T

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

940E

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

983D

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

985K

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

987Q

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,034L

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,054G

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,055T

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,056S

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,057G

polypeptide substrate binding site
871S, 938T, 940E, 983D, 985K, 987Q, 1,034L, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)
activation loop (A...

1,030S

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,031D

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,032F

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,033G

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,034L

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,035C

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,036K

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,037M

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,038L

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,039E

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,040G

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,041D

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,042Q

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,043S

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,044S

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,045F

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,049T

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,050A

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,052A

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,053A

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,054G

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,055T

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,056S

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)

1,057G

activation loop (A-loop)
1,030S, 1,031D, 1,032F, 1,033G, 1,034L, 1,035C, 1,036K, 1,037M, 1,038L, 1,039E, 1,040G, 1,041D, 1,042Q, 1,043S, 1,044S, 1,045F, 1,049T, 1,050A, 1,052A, 1,053A, 1,054G, 1,055T, 1,056S, 1,057G
CDD
cd13982 (STKc_IRE1)
ligand binding sit...

1,198K

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,201D

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,205K

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,271A

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,289P

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,321M

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,324S

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)

1,325F

ligand binding site
1,198K, 1,201D, 1,205K, 1,271A, 1,289P, 1,321M, 1,324S, 1,325F
CDD
cd10422 (RNase_Ire1)
kinase interface c...

1,199R

kinase interface
1,199R, 1,297L, 1,301P, 1,304L, 1,305M, 1,309K
CDD
cd10422 (RNase_Ire1)

1,297L

kinase interface
1,199R, 1,297L, 1,301P, 1,304L, 1,305M, 1,309K
CDD
cd10422 (RNase_Ire1)

1,301P

kinase interface
1,199R, 1,297L, 1,301P, 1,304L, 1,305M, 1,309K
CDD
cd10422 (RNase_Ire1)

1,304L

kinase interface
1,199R, 1,297L, 1,301P, 1,304L, 1,305M, 1,309K
CDD
cd10422 (RNase_Ire1)

1,305M

kinase interface
1,199R, 1,297L, 1,301P, 1,304L, 1,305M, 1,309K
CDD
cd10422 (RNase_Ire1)

1,309K

kinase interface
1,199R, 1,297L, 1,301P, 1,304L, 1,305M, 1,309K
CDD
cd10422 (RNase_Ire1)
homodimer interfac...

1,201D

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,205K

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,208D

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,209R

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,268R

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,271A

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,272H

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,275N

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,288Y

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,289P

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,290E

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,320D

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,321M

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

1,324S

homodimer interface
1,201D, 1,205K, 1,208D, 1,209R, 1,268R, 1,271A, 1,272H, 1,275N, 1,288Y, 1,289P, 1,290E, 1,320D, 1,321M, 1,324S
CDD
cd10422 (RNase_Ire1)

Protein sequence

>MCA_03350_1
MSRLKWILHYPYASEGSHNSFYGNQNLFLRFFSSMIWSCLFLSIVLIFISPAQSAFGNPNSKNTLNAKSVESAAVIVADE
DIQQDPLASVDSSSAPLISHSSLLPPQFTDPESLPKSHRTIFASSASHLHQQQDNGNNQGLLTQTDKGMSVSSFVGPRYI
GDYELADIILVCSIDGSIHARDRQTGMEIWSIPGDRPLVQVSSPLDTVSDENVDYTSDSDEKNLIWIVEPLSDGILYYFT
PATGLQQLPISIKQLVSQSPFALQGDDKIYTGSRQTTLFSIDSVTGKVLKVYGARKSDLGSAKCKVSQKSPFNNDQQKQV
AKNNNNPDYDSEEEPNDREDDEDYFDYDYQHWINQQRGSFLIGRTDYMLEIHGKNETIWNVTYSTWGPNNVDLDLAAQHY
KSPDNIYVTPVYNSSILALSTDGRKKPAQWVGEISSVAISFFDVFHPKHDENDKSKNDNKKKDSLILLPQPNHLKDYEID
PKTLSSAFVQKTKDGQWFAMSGKNFPSLVHSAPVASWCQAPNTFKGSIREIENSLIGVHPLSFPEKLVKPSDSSKDLLAI
EDGSRNKNVDKYKKNNAVIRHSTNQHSDNPVYQHYEMARQQDKYAYQHQNVAERPGLPPPSSIITEPTSVIYSSFVRIIE
NVFAFVIFFGALIAAAKLGWLPQLANGVEMIHANINNKKMENIGNKEFEEKPDLVIVQDEKNAQEEYNEVSSDSQQKQLQ
QPKKVEIVEPEKSINNKEEGTENESQEQQNSSGSATSTPHKRRKRGTRGGKNSKAKKKLLQQQLQQQQQSGLETLENNQI
RSESLDGDVTPRLIDQIQEDRMVEGNSNINTSQIINGALRKDLIGSASSILLAPTLSSSLKCSEEVLGYGSHGTVVFKGE
FENREVAVKRMLLEFYDVASHEVSLLQESDDHPNVIRYYCKQQTERFLYIALELCPGTLEDLVEKKPNSLYELNNYISSP
TQIMYQIASGVQHLHSLKIVHRDLKPQNILVAPPKVSKRLGTGNSESGNAPGSSASNSISNNNSIRMLISDFGLCKMLEG
DQSSFRATTAQAAGTSGWRAPELLLDDLESNTEHFKNINGNANNNSTMSSSTNTSSEPLIIDSISNRRATRAIDIFSLGC
VFYYILSKGQHPFGDKILREANIVQNLYSLDYLDPETSEMEDAVEARDLVERMIARNPKQRPEASEVLLHPLFWSVRKRL
DFLLKVSDRFEIELRDPPSELFKKLERHAPEVVGQDWHSRLDKLFVDNLGKYRKYHGDRILDLLRAMRNKAHHYNDLPPE
LRTIVGGYPEGYYKYFLKRFPKLLMVIYKVVREEGLYKEDMFVSFFTNRDSL

GO term prediction

Biological Process

GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

Molecular Function

GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component