Protein

MCA_03345_1

Length
343 amino acids

Gene name: KIN28

Description: Serine/threonine-protein kinase Kin28; in S. cerevisiae it is a subunit of transcription factor TFIIH.

Browser: contigB:4111695-4112727-

RNA-seq: read pairs 400, FPKM 14.4, percentile rank 33.1% (100% = highest expression)

Protein function

Annotation:KIN28Serine/threonine-protein kinase Kin28; in S. cerevisiae it is a subunit of transcription factor TFIIH.
KEGG:K02202CDK7 cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
EGGNOG:0PFPZKIN28serine threonine-protein kinase
SGD closest match:S000002266KIN28Serine/threonine-protein kinase KIN28
CGD closest match:CAL0000201956orf19.6239TFIIH complex serine/threonine-protein kinase subunit

Protein alignments

%idAln lengthE-value
MIA_01600_176.68%3430.0MIA_01600_1
A0A167EL28_9ASCO66.37%3362e-153TFIIH complex serine/threonine-protein kinase subunit KIN28 OS=Sugiyamaella lignohabitans GN=KIN28 PE=3 SV=1
A0A1E3PGT5_9ASCO69.07%2912e-152Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_74994 PE=3 SV=1
A0A0J9X792_GEOCN63.82%3401e-151Similar to Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase, subunit of the transcription factor TFIIH OS=Geotrichum candidum GN=BN980_GECA04s07468g PE=3 SV=1
UniRef50_Q75BH167.35%2914e-146ADL283Wp n=15 Tax=Dikarya TaxID=451864 RepID=Q75BH1_ASHGO
Q5AAS1_CANAL66.33%2941e-148TFIIH complex serine/threonine-protein kinase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6239 PE=3 SV=1
KIN28_YEAST64.48%2901e-140Serine/threonine-protein kinase KIN28 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KIN28 PE=1 SV=1
A0A060SWL2_BLAAD66.12%3073e-137ARAD1A05918p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A05918g PE=4 SV=1
Q6CAB2_YARLI62.80%2931e-134YALI0D04334p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04334g PE=3 SV=1
A0A1E4TFE6_9ASCO60.00%2953e-129Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2208 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0062

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 343

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. PIRSF000654 (ILK)
  4. cd07841 (STKc_CDK7)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd07841
  3. CDK/cyclin interfa...
  4. polypeptide substr...
  5. activation loop (A...

Protein sequence

>MCA_03345_1
MDNYTKEKKVGEGTYAEVYVGRRITDSRLVAIKAIKLSGFKDGLDMSAIREIKFLQEIRHLNVIELIDVFATTASVSLVL
EYLPADLEMLIKDKSIIFKPSDVKSWLLMTLRGLHHCHRSFILHRDLKPNNLLVSPDGQLKLADFGLARAMALPLEEMTP
TVVTRWYRAPELLLGARHYTGAIDIWSVGTIFAELMLRTPYLPGADDVDQLIITFKALGTPTEQTWPGMTSLPGFKRLQA
KIEKFPAPRRADLQNLFLAASDNALNLLCGMLQLNPTKRLNTVTALQSPYFTESPPPTKPTDLPKKEEQFTGSAGDIEEK
KRKEQLRQSMINQTREKRFQSQV

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.