Protein
MCA_03342_1
Length
392 amino acids
Gene name: UNG1
Description: Uracil-DNA glycosylase
Browser: contigB:4107477-4108656-
RNA-seq: read pairs 544, FPKM 17.1, percentile rank 37.2% (100% = highest expression)
Protein function
| Annotation: | UNG1 | Uracil-DNA glycosylase | |
|---|---|---|---|
| KEGG: | K03648 | UNG | uracil-DNA glycosylase [EC:3.2.2.27] |
| EGGNOG: | 0PGX3 | UNG1 | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) |
| SGD closest match: | S000004483 | UNG1 | Uracil-DNA glycosylase |
| CGD closest match: | CAL0000183494 | UNG1 | Uracil-DNA glycosylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01597_1 | 65.86% | 331 | 3e-141 | MIA_01597_1 |
| A0A0J9X921_GEOCN | 63.16% | 304 | 5e-123 | Uracil-DNA glycosylase OS=Geotrichum candidum GN=UNG1 PE=3 SV=1 |
| A0A060SX41_BLAAD | 59.12% | 296 | 2e-112 | Uracil-DNA glycosylase OS=Blastobotrys adeninivorans GN=UNG1 PE=3 SV=1 |
| UniRef50_A0A060SX41 | 59.12% | 296 | 4e-109 | Uracil-DNA glycosylase n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060SX41_BLAAD |
| A0A1E3PHC8_9ASCO | 58.16% | 282 | 1e-105 | Uracil-DNA glycosylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=UNG1 PE=3 SV=1 |
| A0A161HK53_9ASCO | 62.55% | 243 | 6e-101 | Uracil-DNA glycosylase OS=Sugiyamaella lignohabitans GN=UNG1 PE=3 SV=1 |
| A0A1E4TJ57_9ASCO | 60.31% | 257 | 4e-101 | Uracil-DNA glycosylase (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17222 PE=3 SV=1 |
| Q6CAC0_YARLI | 57.37% | 251 | 3e-95 | Uracil-DNA glycosylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=UNG1 PE=3 SV=1 |
| UNG_YEAST | 55.09% | 265 | 3e-90 | Uracil-DNA glycosylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UNG1 PE=1 SV=1 |
| A0A1D8PKH5_CANAL | 50.34% | 296 | 7e-82 | Uracil-DNA glycosylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UNG1 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2769
Predicted cleavage: 15
Protein family membership
- Uracil-DNA glycosylase family 1 (IPR002043)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
392
Detailed signature matches
no IPR
Unintegrated signatures
-
-
SM00987 (UDG_2_a)
-
mobidb-lite (disord...)
Residue annotation
-
ligand binding sit...
-
UGI interface cd10...
-
active site cd10027
-
catalytic site cd1...
Protein sequence
>MCA_03342_1 MPPKRSITSFFQPTGKISGPAEKKQATEKLSTSKPLTTNSPTPKLTFKFDKAKWIQSLTPHQRAMLELEIETIDDSWLPV LHTELTKPYFIKLKEFLAQEKKSNAQIFPPENDIYSWTRLTPFDKVKVVILGQDPYHNVNQAHGLAFSVKPPTPPPPSLK NIYIGIKKDYPDFTIPKTNGLLIQWAKQGVLMLNTCLTVRAHNANSHAKHGWETFTEQVLRAVANNSNGKGVVFLAWGNP AAKRMEIIKPDLRVHKILKTVHPSPLSASRGFFDAGHFRKTNEFLEERYGPGGIINWSVGHQCHIKEIEDKLASAASKES EENEQSKTEENEQPKTEEKKEETSELKPTETEASEKATESKESTTTDSKKEESESKPNNDDEPKSNDDEKAL
GO term prediction
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Cellular Component
None predicted.