Protein
MCA_03325_1
Length
419 amino acids
Gene name: CWC2
Description: Pre-mRNA-splicing factor CWC2
Browser: contigB:4024524-4025784-
RNA-seq: read pairs 945, FPKM 27.8, percentile rank 50.5% (100% = highest expression)
Protein function
| Annotation: | CWC2 | Pre-mRNA-splicing factor CWC2 | |
|---|---|---|---|
| EGGNOG: | 0PG3V | CWC2 | Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4 U6 snRNA complex. May provide the link between the nineteen complex NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre- mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle |
| SGD closest match: | S000002368 | CWC2 | Pre-mRNA-splicing factor CWC2 |
| CGD closest match: | CAL0000184865 | CWC2 | Pre-mRNA-splicing factor CWC2 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_05645_1 | 62.77% | 274 | 3e-118 | MIA_05645_1 |
| A0A0J9X9J3_GEOCN | 58.70% | 276 | 3e-113 | Similar to Saccharomyces cerevisiae YDL209C CWC2 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNA OS=Geotrichum candidum GN=BN980_GECA05s02254g PE=4 SV=1 |
| A0A060TCZ8_BLAAD | 55.31% | 311 | 2e-110 | ARAD1D46970p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D46970g PE=4 SV=1 |
| A0A1E3PM35_9ASCO | 56.00% | 275 | 3e-103 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46487 PE=4 SV=1 |
| UniRef50_A0A1E3PM35 | 56.00% | 275 | 7e-100 | Uncharacterized protein n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PM35_9ASCO |
| CWC2_YARLI | 54.71% | 276 | 4e-103 | Pre-mRNA-splicing factor CWC2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CWC2 PE=3 SV=1 |
| A0A1E4TC76_9ASCO | 49.46% | 277 | 2e-89 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3878 PE=4 SV=1 |
| A0A161HIT2_9ASCO | 62.50% | 168 | 8e-67 | Cwc2p OS=Sugiyamaella lignohabitans GN=CWC2 PE=4 SV=1 |
| CWC2_CANAL | 38.05% | 297 | 2e-54 | Pre-mRNA-splicing factor CWC2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CWC2 PE=3 SV=1 |
| CWC2_YEAST | 34.67% | 300 | 4e-44 | Pre-mRNA-splicing factor CWC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC2 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0260
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
50
100
150
200
250
300
350
419
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_03325_1 MATKRKEQDDQPPKTAESNGNEISAQDMQVVTKKLKTDKPKKKKRRPARVQKEPGTVDNTPPQTGTVYNIWYLKWSGGDR YEDAAGYSQRKAAGRCNIAKDSGYTLANPEYDYEASVLASAKASKALTQSNSSKELVPAGGQVVGETQKQQGSYFCLYFA RGLCTQGKNCHFLHRLPTDDDFFPQTVDCFGRDKFADYRDDMGGTGSFLRSNRTLYVGRINESSGSKTSETVEQVVSRHF QEWGKIERIRVLNDRGVAFVTYSNEANAQFAKEAMAHQSLDNDEVLNVRWASEDPNPQAQMREKKLIEKRAIQSIQRMLM VGSQNSQKENELRQLENSRSDVKAIEYENTENIENTKSNENTTDQSATENLTEQAPTQSIIPSYLLDRIAYLKSQLKYDS PVETYSSQPLKLVEDYESD
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0046872 metal ion binding
Cellular Component
None predicted.