Protein
MCA_03322_1
Length
811 amino acids
Gene name: SRB4
Description: Mediator of RNA polymerase II transcription subunit 17
Browser: contigB:4018066-4020563-
RNA-seq: read pairs 1052, FPKM 16.0, percentile rank 35.5% (100% = highest expression)
Protein function
| Annotation: | SRB4 | Mediator of RNA polymerase II transcription subunit 17 | |
|---|---|---|---|
| KEGG: | K15134 | SRB4 | mediator of RNA polymerase II transcription subunit 17, fungi type |
| EGGNOG: | 0PK46 | SRB4 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) |
| SGD closest match: | S000000824 | SRB4 | Mediator of RNA polymerase II transcription subunit 17 |
| CGD closest match: | CAL0000197516 | SRB4 | Mediator of RNA polymerase II transcription subunit 17 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9X7P2_GEOCN | 34.84% | 574 | 3e-73 | Similar to Saccharomyces cerevisiae YER022W SRB4 Subunit of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA05s02287g PE=4 SV=1 |
| UniRef50_A0A0J9X7P2 | 34.84% | 574 | 7e-70 | Similar to Saccharomyces cerevisiae YER022W SRB4 Subunit of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7P2_GEOCN |
| MIA_05648_1 | 36.59% | 533 | 3e-73 | MIA_05648_1 |
| A0A060TDV7_BLAAD | 33.33% | 549 | 2e-57 | ARAD1D47080p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D47080g PE=4 SV=1 |
| A0A167D505_9ASCO | 35.48% | 434 | 6e-55 | Srb4p OS=Sugiyamaella lignohabitans GN=SRB4 PE=4 SV=1 |
| A0A1E3PKB8_9ASCO | 30.85% | 457 | 4e-46 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51160 PE=4 SV=1 |
| MED17_YARLI | 31.43% | 420 | 4e-32 | Mediator of RNA polymerase II transcription subunit 17 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SRB4 PE=3 SV=1 |
| MED17_CANAL | 26.96% | 345 | 1e-23 | Mediator of RNA polymerase II transcription subunit 17 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SRB4 PE=3 SV=3 |
| MED17_YEAST | 38.37% | 86 | 4e-11 | Mediator of RNA polymerase II transcription subunit 17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRB4 PE=1 SV=1 |
| A0A1E4THI1_9ASCO | 36.59% | 82 | 5e-08 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2921 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0067
Protein family membership
- Mediator complex, subunit Med17 (IPR019313)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_03322_1 MTNLNNNDVLVSLEPKIKDEIIVQEETAIPLQQLIVRITQERGPFATLSEEALLDEIEYKIKNGTDENDEEDEESTEIKS DDKDGKDTDVNESSVKNEATDSDTPSKLDDNVMDDETFEKTREKLIAFLAAAKEEAALSQDFVALLMSGKKPETGLKSMS PYLRANIPPGSLNADLARPDPHKSTTTIGGGVGRRGGTNHHDDGADDEDEDGYGRGNNNGQKGTTDGGDDDHLVCAGWKL ESLERTSASLKSAAKRLRGEVVKETRYWDSVLAIVSNGEVIYKIRAGETRGLGVKYGFGDSGSLYTHKGQAVLRRLNDGT ISFQTEGLGSKQNKIVRVTLYKIINGQRTKTSVSSPLLVSDFLKKKKKQEGGDDSSDGKDGENDKRDNLKVLKEIKHARS LLFEEELFFEMIQEARMLTSHRVTVTNDEKIVAHMYDEILEIDFVDPTEDLEHESECGRPFSDDFSAQLGGESLGNNDIE GRATEPITTTTNLEGLSSSSSSPFSNEILLPTRANLISTAFRILLCNFHRRNLQKKKQIPSPLTSTGSSSGTGSNGTPGT GSGSRKPGGGVNSTNNINTVNSIGTSLSTASATTSSSNSNSAAASGNSLSDIEKRSIFILRPVLAHVLHEKILKRTKKTL ELLIENELQSVLSDESSSATINLESIDSSATSNSNNNNNNNKQKNNNDDVIITGKSVADSILRNSLSHLGKLAVQPLSKF TIVIPGVLVIVIITGSPIQSHSLLYEAAVYKWINNNINEESKKLGGGGGENNNDNELIQEIQKGIPISSNGFNDLSDLED WVRWVLQTKSS
GO term prediction
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
Molecular Function
GO:0001104 RNA polymerase II transcription cofactor activity
Cellular Component
GO:0016592 mediator complex