MCA_03299_1

Protein

Length

1,396 amino acids

Gene name: CCC2B

Description: Cu(+2)-transporting P-type ATPase

Browser: contigB:3961523-3965776-

RNA-seq: read pairs 1438, FPKM 12.7, percentile rank 30.4% (100% = highest expression)

Protein function

Annotation:		CCC2B	Cu(+2)-transporting P-type ATPase
EGGNOG:	0PG9C	PGUG_05843	P-type ATPase
SGD closest match:	S000002678	CCC2	Copper-transporting ATPase
CGD closest match:	CAL0000174668	CRP1	Crp1p

Protein alignments

	%id	Aln length	E-value
A0A0J9X475_GEOCN	50.04%	1177	0.0	Similar to Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase OS=Geotrichum candidum GN=BN980_GECA02s04217g PE=3 SV=1
UniRef50_A0A0J9X475	50.04%	1177	0.0	Similar to Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X475_GEOCN
A0A1E3PSQ9_9ASCO	45.51%	1169	0.0	Heavy metal translocatin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_20770 PE=3 SV=1
Q6CFX9_YARLI	46.55%	1173	0.0	YALI0B02684p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B02684g PE=3 SV=1
A0A060T9X5_BLAAD	41.79%	1400	0.0	ARAD1D15114p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D15114g PE=3 SV=1
A0A1E4TLG3_9ASCO	43.00%	1128	0.0	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30708 PE=3 SV=1
A0A1D8PEI4_CANAL	41.33%	1159	0.0	Crp1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CRP1 PE=3 SV=1
A0A161HIL6_9ASCO	53.04%	756	0.0	Cu(2+)-transporting P-type ATPase CCC2 OS=Sugiyamaella lignohabitans GN=CCC2 PE=3 SV=1
MIA_01052_1	28.49%	1109	3e-95	MIA_01052_1
ATU2_YEAST	27.39%	1066	2e-85	Copper-transporting ATPase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCC2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0056

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IB (IPR027256)

Domains and repeats

Domain
3 - 89
Heavy metal-associated domain, HMA (IPR006121)
247 - 335
Heavy metal-associated domain, HMA (IPR006121)
361 - 455
Heavy metal-associated domain, HMA (IPR006121)
483 - 557
Heavy metal-associated domain, HMA (IPR006121)
699 - 768
P-type ATPase, transmembrane domain (IPR023298)
805 - 894
P-type ATPase, A domain (IPR008250)
895 - 996
P-type ATPase, transmembrane domain (IPR023298)
998 - 1,022
HAD-like domain (IPR023214)
1,030 - 1,283
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
1,322 - 1,352
P-type ATPase, transmembrane domain (IPR023298)

1 200 400 600 800 1000 1200 1396

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  795 - 1,020
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR027256

P-type ATPase, subfamily IB
1. TIGR01525
  
  687 - 1,382
  
  TIGRFAMs
  TIGR01525 (TIGR01525)
IPR006121

Heavy metal-associated domain, HMA
1. PS50846 (HMA_2)
  
  361 - 455
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  252 - 333
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  3 - 89
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  487 - 557
  
  PROSITE profiles
  PS50846 (HMA_2)
2. cd00371 (HMA)
  
  489 - 551
  
  CDD
  cd00371 (HMA)
  
  254 - 332
  
  CDD
  cd00371 (HMA)
3. SSF55008 (HMA, heav...)
  
  247 - 335
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
  
  483 - 551
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  699 - 768
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  895 - 996
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  1,322 - 1,352
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  805 - 894
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  1,141 - 1,283
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  1,079 - 1,112
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  998 - 1,022
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. G3DSA:3.40.11...
  
  1,030 - 1,178
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  1,012 - 1,018
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

976 - 1,332

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

619 - 688

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,386 - 1,396

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

748 - 910

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

1,179 - 1,389

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)

598 - 1,029

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:3.30.70...

4 - 88

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

355 - 457

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

481 - 553

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

250 - 339

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)
NON_CYTOPLASM... (N...)

1 - 592

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,355 - 1,365

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

932 - 950

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

711 - 729

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

802 - 989

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

1,006 - 1,260

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

1,269 - 1,281

PRINTS
PR00119 (CATATPASE)

1,010 - 1,024

PRINTS
PR00119 (CATATPASE)

843 - 857

PRINTS
PR00119 (CATATPASE)

1,171 - 1,181

PRINTS
PR00119 (CATATPASE)

1,246 - 1,265

PRINTS
PR00119 (CATATPASE)
TMhelix

688 - 710

TMHMM
TMhelix (TMhelix)

953 - 975

TMHMM
TMhelix (TMhelix)

1,331 - 1,353

TMHMM
TMhelix (TMhelix)

1,363 - 1,385

TMHMM
TMhelix (TMhelix)

911 - 933

TMHMM
TMhelix (TMhelix)

597 - 619

TMHMM
TMhelix (TMhelix)

725 - 747

TMHMM
TMhelix (TMhelix)

642 - 664

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

689 - 710

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,333 - 1,354

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

951 - 975

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

911 - 931

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

730 - 747

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,366 - 1,385

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

593 - 618

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02094 (P-type_ATP...)

596 - 1,369

CDD
cd02094 (P-type_ATPase_Cu-like)
mobidb-lite (disord...)

1,212 - 1,238

MobiDB Lite
mobidb-lite (disorder_prediction)

163 - 196

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

metal-binding site...

260M

metal-binding site
260M, 261S, 262C, 265C
CDD
cd00371 (HMA)

261S

metal-binding site
260M, 261S, 262C, 265C
CDD
cd00371 (HMA)

262C

metal-binding site
260M, 261S, 262C, 265C
CDD
cd00371 (HMA)

265C

metal-binding site
260M, 261S, 262C, 265C
CDD
cd00371 (HMA)
metal-binding site...

495M

metal-binding site
495M, 496F, 497C, 500C
CDD
cd00371 (HMA)

496F

metal-binding site
495M, 496F, 497C, 500C
CDD
cd00371 (HMA)

497C

metal-binding site
495M, 496F, 497C, 500C
CDD
cd00371 (HMA)

500C

metal-binding site
495M, 496F, 497C, 500C
CDD
cd00371 (HMA)
HM-ATPase signatur...

967C

HM-ATPase signature motif
967C, 968P, 969C
CDD
cd02094 (P-type_ATPase_Cu-like)

968P

HM-ATPase signature motif
967C, 968P, 969C
CDD
cd02094 (P-type_ATPase_Cu-like)

969C

HM-ATPase signature motif
967C, 968P, 969C
CDD
cd02094 (P-type_ATPase_Cu-like)
putative Cu bindin...

967C

putative Cu binding site
967C, 969C, 1,339Y
CDD
cd02094 (P-type_ATPase_Cu-like)

969C

putative Cu binding site
967C, 969C, 1,339Y
CDD
cd02094 (P-type_ATPase_Cu-like)

1,339Y

putative Cu binding site
967C, 969C, 1,339Y
CDD
cd02094 (P-type_ATPase_Cu-like)
phosphorylation si...

1,012D

phosphorylation site
1,012D
CDD
cd02094 (P-type_ATPase_Cu-like)
P-type ATPase sign...

1,012D

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)

1,013K

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)

1,014T

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)

1,015G

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)

1,016T

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)

1,017L

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)

1,018T

P-type ATPase signature motif
1,012D, 1,013K, 1,014T, 1,015G, 1,016T, 1,017L, 1,018T
CDD
cd02094 (P-type_ATPase_Cu-like)
putative ATP bindi...

1,012D

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,013K

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,014T

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,084I

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,103V

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,104G

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,105N

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,132I

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,179T

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,180G

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,181D

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,203E

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,206P

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,209K

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,248D

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,251N

putative ATP binding site
1,012D, 1,013K, 1,014T, 1,084I, 1,103V, 1,104G, 1,105N, 1,132I, 1,179T, 1,180G, 1,181D, 1,203E, 1,206P, 1,209K, 1,248D, 1,251N
CDD
cd02094 (P-type_ATPase_Cu-like)
putative Cu bindin...

1,340N

putative Cu binding site
1,340N, 1,368M
CDD
cd02094 (P-type_ATPase_Cu-like)

1,368M

putative Cu binding site
1,340N, 1,368M
CDD
cd02094 (P-type_ATPase_Cu-like)

Protein sequence

>MCA_03299_1
MDYYLITIGNIHCESCGAAIKKTLQPYLQAGSESGSGWDIAVSIPERSILVTFPSSEESSSSNASNKELPSNLEEMADAL
AHAGFEVLEIEKLTPQEIEAQNSSLAANSASYIYSLTNSPLQVAYTWTWKPVVNILSYPFKQWTMQRTHRQYCQVCRANH
AHFKHSPPHQEEKKESPEPKDADVPQDSDKDETTTKWKLPSSIFPSSLKGKRRSSSFSDISDDSTVVATPLSVTDEPLVV
CDDDKSGNSMYKATFSIGGMSCSSCSNAITSGVQSLYPDILGPDSGTGKFAVDLMNHCAFATFPQTGEGLAGAEKFANQI
SAAIEDLGYDSEVVEVVKIQGDESHTTLTTQPKNEYPKTYKVIASIGGMTCSSCANSISENTLSATFENQLKNTTLRYTV
EDAKISILDHAATFIIKVEIQQQGDISEVSEKDELTDIENFLQDAVESSGFDFELDTIKKVEPAKISTKDKVINDEFDFD
KPQSPKTVTLSVSGMFCRHCPERINSLVKSLSPNVTLITPISLESPTLKLSYTPKVPKFTIRSIVNAIENATIVPSASTE
SSNTHREFNVKIIHPLTLEQRSKLIAKRERTRLVYRAIFVIIVAIPTFIIGIVGMALLPSSNSFRKFLHEPMWAGNVSRD
TWALLFMATPVYFYGADTFHTRAIKEVRSLWKRNVPWTRRIFKFGSMNLLMSLGTTVAYFASIALIILAAQSQPAHHNDG
SGKSGYTTTYFDSVVFLTMFLLLGRLLEAFSKSKAESAVSLLAALRPNVVRLIQEVELLDDTKQTGDISDADTEENSHEE
KYKFGQDVEISTDLIERGDFIRILPGMSPPADSIIVSGETAFDESALTGESIPLVRGIGDIVYAGTVNTGTKSIVARISA
SEGHSMLDQIVDAVREGQLHRAPIERFADKLTGVFVPIVTFLAIITWVIWLSLGYSGALPESYMDIDLGGWAVWSLQFSL
SVFVVACPCGIGLAAPTALYVGTGLAAKNGILVKGGGEAFQEGANIDVVCFDKTGTLTYGGDPKVTNVQALIESEPQLLL
LKLVDELEAGTTHPLGIAVRKYYKEASENSELEYDFQVSNIEEISGRGLKGIISNSTITEAIVGNEKFLKEHDVAIDSSI
IHEWKEEGKSIILLAIKKPSVSESFLPALAIAVADEIRPEASGVISALQNLNIDTWMITGDNEVTGKAVARQVGIPPEHV
IAEVLPKEKAEKIKWLQRQPHTTKSNKSKGKSKEEDKPARSIVAMVGDGVNDAPSLAAADVGIAIGSGSDIAMSSAKFVL
LKTSSIGEKKSANNTNSVGIALSPSSASGTYLNSILVLIDLSRKVFRRVKFNFAWALVYNCIAIPIAAGVIYPYKNSRLD
PVWASLAMALSSISVISSSLLLKFYKSPVVKIQNKK

GO term prediction

Biological Process

GO:0006812 cation transport
GO:0030001 metal ion transport

Molecular Function

GO:0000166 nucleotide binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features