Protein

MCA_03220_1

Length
297 amino acids

Browser: contigB:3699879-3700941-

RNA-seq: read pairs 2185, FPKM 90.6, percentile rank 77.1% (100% = highest expression)

Protein function

KEGG:K03564BCP peroxiredoxin Q/BCP [EC:1.11.1.15]
EGGNOG:0PRGFFG10296.1Disrupter of telomere silencing protein Dot5
SGD closest match:S000001272DOT5Peroxiredoxin DOT5
CGD closest match:CAL0000195251DOT5Thioredoxin peroxidase

Protein alignments

%idAln lengthE-value
MIA_01196_149.48%1941e-57MIA_01196_1
A0A0J9XHL5_GEOCN49.29%2117e-55Similar to Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth OS=Geotrichum candidum GN=BN980_GECA15s01209g PE=4 SV=1
UniRef50_A0A0J9XHL549.29%2111e-51Similar to Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHL5_GEOCN
A0A1E3PRH7_9ASCO56.46%1472e-51Thioredoxin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82000 PE=4 SV=1
Q6C5B6_YARLI53.09%1623e-51YALI0E19448p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E19448g PE=4 SV=1
A0A1E4TMA1_9ASCO50.91%1653e-51Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30828 PE=4 SV=1
Q5A7P9_CANAL46.60%1913e-48Thioredoxin peroxidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DOT5 PE=4 SV=1
DOT5_YEAST44.66%2061e-46Peroxiredoxin DOT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DOT5 PE=1 SV=1
A0A167DIE3_9ASCO47.80%1826e-46Dot5p OS=Sugiyamaella lignohabitans GN=DOT5 PE=4 SV=1
A0A060T9G0_BLAAD33.68%1902e-30ARAD1D17688p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17688g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7906
Predicted cleavage: 22

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 297

Detailed signature matches

  1. Domain IPR012336
    Thioredoxin-like fold
    1. SSF52833 (Thioredox...)
  2. Domain IPR013766
    Thioredoxin domain
    1. PS51352 (THIOREDOXIN_2)
  3. Domain IPR000866
    Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
    1. PF00578 (AhpC-TSA)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.30.10
  2. SFLDS00024 (Peroxir...)
  3. cd03017 (PRX_BCP)
  4. mobidb-lite (disord...)

Residue annotation

  1. SFLDS00024
  2. catalytic triad cd...

Protein sequence

>MCA_03220_1
MTEQQPLRRSTRVAASQKKREATEPEQPAAKPTVKRTKTNENASTTPKLSVGDELPQVTLKDHEGNDVDIKKEIASGVAV
IFAYPKASTPGCTKQACGFRDNYEKYNSLGVKVFGLSADSVNAQKSFHTKQNLNFQLLSDPEYSLIQPLGAKKSPKGVIR
SHWIFKDGKIVVAKVPVSPQESIEQALESVNEYTSGGDKIEEKAAEETAKTEESKPAEEESKPEESKPEESKPEEPKSEE
SKSEETKPALESTTEDGSKPSEEDSKKTEETTTTVTEEVKVSTTTEATTANGDKKEE

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.