Protein

MCA_03199_1

Length
826 amino acids

Gene name: HEM14

Description: Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes a step in the heme biosynthetic pathway

Browser: contigB:3629378-3631859-

RNA-seq: read pairs 2246, FPKM 33.6, percentile rank 55.8% (100% = highest expression)

Protein function

Annotation:HEM14Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes a step in the heme biosynthetic pathway
KEGG:K00231PPOX protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15]
EGGNOG:0PH5THEM14Protoporphyrinogen oxidase
SGD closest match:S000000816HEM14Protoporphyrinogen oxidase
CGD closest match:CAL0000182679HEM14Protoporphyrinogen oxidase

Protein alignments

%idAln lengthE-value
MIA_03555_150.26%7760.0MIA_03555_1
A0A0J9X7Z4_GEOCN46.03%7800.0Similar to Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway OS=Geotrichum candidum GN=BN980_GECA04s01572g PE=4 SV=1
UniRef50_A0A0J9X7Z446.03%7800.0Similar to Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7Z4_GEOCN
A0A167DXS9_9ASCO34.56%6775e-113Oxygen-dependent protoporphyrinogen oxidase OS=Sugiyamaella lignohabitans GN=HEM14 PE=4 SV=1
A0A060T742_BLAAD33.02%6421e-103ARAD1C25718p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25718g PE=4 SV=1
A0A1E3PSF4_9ASCO26.85%6748e-36Protoporphyrinogen oxidase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49001 PE=4 SV=1
A0A1D8PEF0_CANAL26.30%4412e-28Protoporphyrinogen oxidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM14 PE=3 SV=1
PPOX_YEAST23.18%6042e-28Protoporphyrinogen oxidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM14 PE=1 SV=1
Q6C826_YARLI29.38%4393e-28Protoporphyrinogen oxidase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23331g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9842
Predicted cleavage: 37

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 826

Detailed signature matches

  1. Family IPR004572
    Protoporphyrinogen oxidase
    1. TIGR00562
  2. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. G3DSA:3.50.50.60
    2. SSF51905 (FAD/NAD(P...)
  3. Domain IPR002937
    Amine oxidase
    1. PF01593 (Amino_oxidase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.31...
  2. G3DSA:3.90.66...
  3. mobidb-lite (disord...)

Protein sequence

>MCA_03199_1
MLRLHSQRVSRHTHLLLNRYPYLLHASRYQKLVYRSNSTNSPNSEKNNNSPIPDGPASKQATHSRLMCLREPGDDPDRYR
DEDNGTFGGRVIQPEDEQSYAHLNVLELIDRPEKRADLFPMLKKKDILSSHTYMDHNGNKSDDHLLFSDIDDATNAANLA
EAIKELGDLPTWHEVLQKTVETVTGDKKSLELQLTRIHDLKPGDQVGIIGAGISGLTLAWFLGNARPDLRIRVYEKASNV
GGWMQSEPVTLNTSEGKIEDINEWGPRTLQARHAGTSLLRVMLRKIGALDKLFYGVPNAALANRKGVLFNGKPFQLPKSS
VAEILAFFRSPISKGTKFAPFRDLFLRPRKRTTRDEPLSSYISRRFGKAISERFLSAVMRGIYAGDVDELSSRSVARLGK
LYANEPDTPSLISSAIGGSARNADAYAATVYVALLQAMLELPYEASLKEMHKYSVAVLAEGGIKKLAETIEDDLEQHFEN
VEIWKDTNIESLKLINDESNESAIAIESTRKTFDSTTKPDITEAKWVVSTIPSYSLSEILKKTDEALAESISSKFKYTTV
GVVNVNVKAPKHVGHNWFGYLVSKAEDKNGYNPHGLLGLIFNTAVRNAALPINSIPVPHPYEVMTVHKKGSNRGESFLDN
YDMDTYKNDHLKFHLFTDAPQLDKDNKPLKAYERITKGDGDAELPTHSNMTLMFGGHLWNDPSKIPTEAELIEATRSIIK
DHLGCSLDDDNKDVVSDIQVRIQHNCIPKYSVGHKENVQMAKDGVAKAFGSRLTLSGTAFGRGVGIGDNVVDSFWLAARH
SPERMLIFPTVYMNQWLTLNYPSVLK

GO term prediction

Biological Process

GO:0006779 porphyrin-containing compound biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.