Protein
MCA_03189_1
Length
351 amino acids
Gene name: LYS20
Description: Homocitrate synthase involved in lysine biosynthesis, DNA repair and histone eviction; locates to both the nucleus and mitochondria
Browser: contigB:3604957-3606013-
RNA-seq: read pairs 1545, FPKM 54.2, percentile rank 67.0% (100% = highest expression)
Protein function
| Annotation: | LYS20 | Homocitrate synthase involved in lysine biosynthesis, DNA repair and histone eviction; locates to both the nucleus and mitochondria | |
|---|---|---|---|
| KEGG: | K01640 | E4.1.3.4 | hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] |
| EGGNOG: | 0PG5B | Hydroxymethylglutaryl-CoA lyase | |
| SGD closest match: | S000002341 | LYS20 | Homocitrate synthase, cytosolic isozyme |
| CGD closest match: | CAL0000201759 | LYS22 | Lys22p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9XGB3_GEOCN | 74.43% | 305 | 8e-165 | Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA13s00648g PE=4 SV=1 |
| MIA_05652_1 | 69.18% | 305 | 4e-150 | MIA_05652_1 |
| A0A060T3U2_BLAAD | 65.03% | 306 | 2e-139 | ARAD1C42812p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42812g PE=4 SV=1 |
| A0A167FIV1_9ASCO | 63.84% | 307 | 1e-135 | Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_2986 PE=4 SV=1 |
| Q6CDN6_YARLI | 59.15% | 306 | 9e-127 | YALI0B22550p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B22550g PE=4 SV=1 |
| A0A1E4T9F9_9ASCO | 57.65% | 307 | 3e-115 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4552 PE=4 SV=1 |
| UniRef50_E9H2A9 | 52.94% | 306 | 4e-108 | Putative uncharacterized protein n=8 Tax=Daphnia TaxID=6668 RepID=E9H2A9_DAPPU |
| A0A1E3PFI7_9ASCO | 50.64% | 314 | 4e-109 | Hydroxymethylglutaryl-CoA lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47465 PE=4 SV=1 |
| HOSC_YEAST | 29.89% | 87 | 1e-06 | Homocitrate synthase, cytosolic isozyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS20 PE=1 SV=1 |
| Q59TC4_CANAL | 28.74% | 87 | 2e-06 | Lys22p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LYS22 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9565
Predicted cleavage: 17
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
50
100
150
200
250
300
351
Detailed signature matches
no IPR
Residue annotation
-
catalytic residues...
-
active site cd07938
-
metal binding site...
Protein sequence
>MCA_03189_1 MFQSSKRLLTTSTLKHLSKNSVTNLVTNTTTKRSGFATTTSSSSGEFIKIVDVSPRDGLQNEKNPVPTETKLSLIEKLTE ANVPCIESTAFVSPKWVPQMADAKQVMKQVLAKYSNNGKDYPVLVPNVQGLQRILDDESLQGIKEIAIFGAASESFSMKN TNVSIKKGLEKLKEVADLAHKNGIKVRGYLSTVIACPYDGPTDASKVADLAQVYLNEIGCYELSLGDTIGVGTPKTIEEM LQKVLQKNGGDARKFAIHAHDTYGQGVANVLRAVEMGIRVVDSSVGGLGGCPYAKGATGNVATEDVVYALHGLGYKTGIN LEQLALIGDWISSTIKRPNASRAGKAISAKL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003824 catalytic activity
Cellular Component
None predicted.