Protein

MCA_03177_1

Length
858 amino acids

Gene name: MSH5

Description: MutS protein homolog 5

Browser: contigB:3552629-3555721+

RNA-seq: read pairs 301, FPKM 4.3, percentile rank 16.4% (100% = highest expression)

Protein function

Annotation:MSH5MutS protein homolog 5
KEGG:K08741MSH5 DNA mismatch repair protein MSH5
EGGNOG:0PF9JMSH5mismatch repair protein
SGD closest match:S000002313MSH5MutS protein homolog 5

Protein alignments

%idAln lengthE-value
MIA_02744_146.55%8250.0MIA_02744_1
A0A0J9X3W8_GEOCN43.98%7640.0Similar to Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family OS=Geotrichum candidum GN=BN980_GECA02s01396g PE=4 SV=1
UniRef50_A0A0J9X3W843.98%7640.0Similar to Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3W8_GEOCN
A0A1D8PLP6_CANAL30.30%8259e-93MutS family protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C402820WA PE=4 SV=1
MSH5_YEAST31.71%6598e-89MutS protein homolog 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH5 PE=1 SV=1
A0A060TCH1_BLAAD25.73%6495e-43ARAD1D39248p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39248g PE=3 SV=1
A0A167EK33_9ASCO27.53%6038e-42Mismatch repair protein MSH3 OS=Sugiyamaella lignohabitans GN=MSH3 PE=3 SV=1
A0A1E4THF9_9ASCO32.22%2708e-36Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31913 PE=3 SV=1
MSH3_YARLI24.01%7042e-34DNA mismatch repair protein MSH3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MSH3 PE=3 SV=1
A0A1E3PGX6_9ASCO33.20%2566e-34Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52294 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0331

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 858

Detailed signature matches

  1. Family IPR017261
    DNA mismatch repair protein MutS/MSH
    1. PIRSF037677 (Msh6)
  2. Domain IPR007696
    DNA mismatch repair protein MutS, core
    1. SM00533 (DNAend)
    2. SSF48334 (DNA repai...)
    3. PF05192 (MutS_III)
  3. Domain IPR007861
    DNA mismatch repair protein MutS, clamp
    1. PF05190 (MutS_IV)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR000432
    DNA mismatch repair protein MutS, C-terminal
    1. PF00488 (MutS_V)
    2. SM00534 (mutATP5)
    3. PS00486 (DNA_MISMAT...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.14...
  2. G3DSA:3.40.50...
  3. cd03281 (ABC_MSH5_euk)

Residue annotation

  1. Walker A/P-loop cd...
  2. ATP binding site c...
  3. Q-loop/lid cd03281
  4. ABC transporter si...
  5. Walker B cd03281
  6. D-loop cd03281
  7. H-loop/switch regi...

Protein sequence

>MCA_03177_1
MPNSSSSIQDSSFIDPKSFENTSTTLASSSRDSESTHIVAIDCQNGYLGCAAYDKETRKMTCYLDTEFQSTDIVAEFKAF
FLQVRDDLTPSLVLISTRFPVQLESIINDRDELTEYEILVRPSLEFSKTSAISYLSKSFIKNPNLFQPDYEEAISYPDFW
IRHHDPNSSSSEINVFNESFFDNDNELGAKCISAILLYISTETEITLDHCVKSFHITALHNNLIISSDSIAALHIFENEV
HPNLHYSKNKLNQGTTTCLFRVLDHTCYQLGTKLLKKWLFKPSTNINTIQSRLDLVEIFLNDTNESKVNSLRASLRKMKN
VLRIIHDMEIYPIPLSDWKTLTLYLKEYNTFQEVIMEVEGIEKSPLFKEFKDTLPSPIIGKMLKLINDTISFEKSEIMSR
VIIQEGVNNELDEAFRVYNNIEKTLSEVARRLSQQLPELSEPLNLIYFPQLGYMIVVSNTDKPTIDQHIEYLLLTHEESQ
IWRLEFSTESHHYYKSLETNSLDEEIGDIFGIICDFELEILQSLQEELYKYFSMIEKSCNLSAQIDCHISLAWAAKKYGY
VKPILSNNLSVEIIDGFHPLYSQLVPTYIPNSTHLATTQENESQSNNIMLVTGANFSGKTVYLTQTALIVYMAHLGSFVP
ATSAKIGIVDRILTRISTRESMSKNKSSFLTDLEQVSSIFRLMTRRSLLIVDEFGKGTESKDGAALFGAFIQYFQNLGSR
SPKLLASTHFHELLEQNIIDSTKNIQVYNMEIHFSENESTKKLTYLYKLKPGKASSSFGICCARMCGVDENILKLAEKIY
EQKVRGENFTTFFFNFSKEEQKNLKKASKVIRKFISQDLELVPDGKKFLHYSIYDERD

GO term prediction

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

Cellular Component

None predicted.