Protein

MCA_03016_1

Length
523 amino acids

Gene name: PRB1

Description: subtilisin-like peptidase

Browser: contigB:3090441-3092013-

RNA-seq: read pairs 32426, FPKM 764.6, percentile rank 95.8% (100% = highest expression)

Protein function

Annotation:PRB1subtilisin-like peptidase
KEGG:K01336E3.4.21.48 cerevisin [EC:3.4.21.48]
EGGNOG:0PFG2SUB8serine protease
SGD closest match:S000000786PRB1Cerevisin
CGD closest match:CAL0000175297orf19.7196Proteinase B

Protein alignments

%idAln lengthE-value
A0A0J9XFX0_GEOCN72.30%5270.0Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III OS=Geotrichum candidum GN=BN980_GECA14s01814g PE=3 SV=1
MIA_04702_167.52%5480.0MIA_04702_1
A0A170QYI2_9ASCO66.82%4460.0Proteinase B OS=Sugiyamaella lignohabitans GN=PRB1 PE=3 SV=1
Q6CED6_YARLI64.93%4420.0YALI0B16500p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B16500g PE=3 SV=1
A0A1E3PKP3_9ASCO64.27%4732e-179Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82571 PE=3 SV=1
A0A060T675_BLAAD58.01%5122e-178ARAD1B09218p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B09218g PE=3 SV=1
UniRef50_W1QEH556.55%5042e-168Cerevisin n=16 Tax=saccharomyceta TaxID=716545 RepID=W1QEH5_OGAPD
A0A1D8PRH0_CANAL63.06%4256e-169Proteinase B OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7196 PE=3 SV=1
PRTB_YEAST62.73%4408e-161Cerevisin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRB1 PE=1 SV=1
A0A1E4THC1_9ASCO52.87%4353e-125Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_65053 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0426

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 450 523

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR010259
    Peptidase S8 propeptide/proteinase inhibitor I9
    1. PF05922 (Inhibitor_I9)
    2. G3DSA:3.30.70.80
  3. Domain IPR009020
    Protease propeptides/proteinase inhibitor I9
    1. SSF54897 (Protease ...)
  4. Domain IPR000209
    Peptidase S8/S53 domain
    1. G3DSA:3.40.50...
    2. PF00082 (Peptidase_S8)
    3. SSF52743 (Subtilisi...)
  5. Domain IPR034193
    Proteinase K-like catalytic domain
    1. cd04077 (Peptidases...)
  6. SITE IPR022398
    Peptidase S8, subtilisin, His-active site
    1. PS00137 (SUBTILASE_HIS)
  7. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM

Residue annotation

  1. calcium binding si...
  2. catalytic triad cd...
  3. active site cd04077
  4. calcium binding si...

Protein sequence

>MCA_03016_1
MKVSVIAASLLPLLNLASAVYIPTDPEVLAQFSQYTKSSKPSEESVVAPFVTSEHAKKNVVKDSYIIVFHDDAEDALISQ
HFMWLDETNSQHILAKGGEQQPLSASSEEGHGIKHMFNVANSLKGYSGKFLPETIEAIRKNKLVKYVEHDSLVFATDFAT
EHDAPWGLARISHREPLSLGNFNKYLYDDEGGEGVTAYVIDTGTNIDHVDFEGRASWGKTIPQGDQDIDGNGHGTHCSGT
IAGKKYGVAKKANVVAVKVLRSNGSGTMSDVLKGVEWAAAAHTAAAKEKKKGFKGSTANMSLGGGKSPSLDLAVNAAVKA
GIHFAVAAGNDNADACNYSPAAAGNAVTVGASDISDNRAYFSNYGKCVDLFGPGVNIQSTYIGSKYAVATLSGTSMASPH
VCGILSYFLSLQPESDSEFALSGAVTTAQLKKNLITYSSEGILDDLPEDTPNLLIYNGGGGNITSFWHPDGKKADKTEER
ESDFSILPVKNIDAKIAKELNKVSADVENLFQMMKNRFFSGSF

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.