Protein
MCA_02894_1
Length
350 amino acids
Browser: contigB:2667508-2668678+
RNA-seq: read pairs 5013, FPKM 176.5, percentile rank 86.6% (100% = highest expression)
Protein function
KEGG: | K10251 | HSD17B12 | 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330] |
---|---|---|---|
EGGNOG: | 0PFH9 | FG05670.1 | Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids (By similarity) |
SGD closest match: | S000000363 | IFA38 | Very-long-chain 3-oxoacyl-CoA reductase |
CGD closest match: | CAL0000189692 | CAALFM_CR06070WA | Very-long-chain 3-oxoacyl-CoA reductase |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
A0A0J9XKS3_GEOCN | 70.62% | 337 | 4e-177 | Very-long-chain 3-oxoacyl-CoA reductase OS=Geotrichum candidum GN=BN980_GECA24s00857g PE=3 SV=1 |
MIA_01069_1 | 68.96% | 335 | 6e-177 | MIA_01069_1 |
A0A167E2V9_9ASCO | 64.62% | 325 | 2e-147 | Very-long-chain 3-oxoacyl-CoA reductase OS=Sugiyamaella lignohabitans GN=IFA38 PE=3 SV=1 |
A0A060TCJ5_BLAAD | 63.33% | 330 | 7e-147 | Very-long-chain 3-oxoacyl-CoA reductase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B16940g PE=3 SV=1 |
MKAR_YARLI | 61.30% | 323 | 2e-139 | Very-long-chain 3-oxoacyl-CoA reductase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0A06787g PE=3 SV=1 |
UniRef50_A3LXZ3 | 60.79% | 329 | 1e-132 | Very-long-chain 3-oxoacyl-CoA reductase n=237 Tax=Fungi TaxID=4751 RepID=MKAR_PICST |
A0A1E3PJ45_9ASCO | 61.44% | 319 | 8e-133 | Very-long-chain 3-oxoacyl-CoA reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52027 PE=3 SV=1 |
MKAR_CANAL | 60.06% | 308 | 9e-128 | Very-long-chain 3-oxoacyl-CoA reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06070WA PE=3 SV=3 |
MKAR_YEAST | 57.14% | 315 | 4e-125 | Very-long-chain 3-oxoacyl-CoA reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IFA38 PE=1 SV=1 |
A0A1E4TE59_9ASCO | 49.53% | 321 | 2e-99 | Very-long-chain 3-oxoacyl-CoA reductase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26095 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4260
Protein family membership
- Short-chain dehydrogenase/reductase SDR (IPR002347)
- Very-long-chain 3-oxoacyl-CoA reductase, fungal (IPR027533)
Domains and repeats
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Domain
1
50
100
150
200
250
300
350
350
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
NON_CYTOPLASM... (N...)
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PIRSF000126 (11-bet...)
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TRANSMEMBRANE (Tran...)
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cd05356 (17beta-HSD...)
Residue annotation
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putative NAD(P) bi...
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active site cd05356
Protein sequence
>MCA_02894_1 MSEIAGSFQSALSGSFSKYPVPTSIVIGLAVIGLFHFTINFLSYFNMLAELFILPGTDFKKYGAKKGSWAVITGASDGIG KEFAYQLAKKGLNVILVSRTESKLEALAKEIAEKYKVKVQIIAFDASTDLPANYEAIKQALGTVDNVTVLINNVGQSHSI PVPFLETSTKEMSDIITINNIATLKITQLVAPKIVESAKNLKTKGLILTMGSFSGLTPTPLLATYSGSKAFLQAWNNALA RELQPQNVDCQIVLSYLVASAMSKIRRTSAMIPSPKQFVHFALKLAGTKRGGAQERYATCTPYWSHALFHWWINAIVGVW SKVVININYNMHVDIRKRALKKAERLAKEK
GO term prediction
Biological Process
GO:0030497 fatty acid elongation
Molecular Function
GO:0016491 oxidoreductase activity
GO:0045703 ketoreductase activity
Cellular Component
GO:0005783 endoplasmic reticulum