Protein

MCA_02853_1

Length
607 amino acids

Browser: contigB:2522290-2524114+

RNA-seq: read pairs 13464, FPKM 273.6, percentile rank 91.2% (100% = highest expression)

Protein function

KEGG:K00602purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
EGGNOG:0PUDFAICARFT_IMPCHas
SGD closest match:S000004727ADE17Bifunctional purine biosynthesis protein ADE17
CGD closest match:CAL0000191899ADE17Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Protein alignments

%idAln lengthE-value
MIA_01779_188.47%6070.0MIA_01779_1
A0A0J9XD15_GEOCN84.62%6110.0Similar to Saccharomyces cerevisiae YMR120C ADE17 Enzyme of 'de novo' purine biosynthesis OS=Geotrichum candidum GN=BN980_GECA10s01088g PE=3 SV=1
A0A161HHE3_9ASCO83.06%6080.0Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 OS=Sugiyamaella lignohabitans GN=ADE17 PE=3 SV=1
A0A060T558_BLAAD82.70%6070.0ARAD1B05016p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B05016g PE=3 SV=1
UniRef50_B9WLL181.61%6090.0Bifunctional purine biosynthesis protein, [includes phosphoribosylaminoimidazolecarboxamide formyltransferase (Ec 2.1.2.3) IMP cyclohydrolase (Ec 3.5.4.10)], putative n=18 Tax=Opisthokonta TaxID=33154 RepID=B9WLL1_CANDC
A0A1E3PDR0_9ASCO82.46%6100.0AICARFT/IMPCHase bienzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53218 PE=3 SV=1
Q5A6R2_CANAL81.28%6090.0Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE17 PE=3 SV=1
Q6C7Y2_YARLI82.54%6070.0YALI0D24409p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D24409g PE=3 SV=1
PUR92_YEAST78.12%6080.0Bifunctional purine biosynthesis protein ADE17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE17 PE=1 SV=2
A0A1E4TFR5_9ASCO77.49%3910.0Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31464 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1159

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 607

Detailed signature matches

  1. Family IPR002695
    AICARFT/IMPCHase bienzyme
    1. PF01808 (AICARFT_IM...)
    2. TIGR00355
    3. MF_00139 (PurH)
    4. SM00798 (aicarft_im...)
    5. PIRSF000414 (PurH)
  2. Domain IPR011607
    Methylglyoxal synthase-like domain
    1. PF02142 (MGS)
    2. G3DSA:3.40.50...
    3. SSF52335 (Methylgly...)
    4. SM00851 (MGS_2a)
  3. Domain IPR016193
    Cytidine deaminase-like
    1. SSF53927 (Cytidine ...)
  4. Domain IPR024051
    AICAR transformylase domain
    1. G3DSA:3.40.14...
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd01421 (IMPCH)

Residue annotation

  1. purine monophospha...
  2. dimer interface cd...
  3. putative catalytic...

Protein sequence

>MCA_02853_1
MSSSQKIAILSVYDKTGLLDLAKGLVNNNVRILASGGTAKMVREAGFPVEDVSSITHAPEMLSGRVKTLHPAVHGGILAR
NIESDEKDLEAQGIDKVDFVVCNLYPFKETISKVNVTIDEAVEEIDIGGVTLLRAAAKNHARVTILSDPNDYHIFIEELS
KDGKVSAETRNTLALKAFEHTAEYDAAISDFFRKQYSEGVSMLPLRYGANPHQKPAQSFVTKGKLPFTVLSGSPGYINLL
DALNSWPLVKELSAALSLPAAASFKHVSPAGAAVGLPLSDVEKKLYFVSDIENLSPLANAYARARGADRMSSFGDWIALS
NIVDVPTAQIISKEVSDGVVAPGYEPEALEILKKKKGGKYCVLQIDPNYNPDSVETRQVYGISLQQKRNDAIINASTFKE
IVSENKDLPQQAIIDLTVATIALKYTQSNSVCYAKNGMVIGLGAGQQSRIHCTRLAGEKADNWWLRQHPKVLGFKWAKGT
KRPDKSNAIDLYVSNQVPTPTIKKYNAETDTIEEVENPERAEYEGKFAEVPEPLTADERAEWLLKNTNVALASDAFFPFP
DNVYRAVKSGVKYISAPFGSVQDKAVLAAANSFDLVYVENNIRLFHH

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003937 IMP cyclohydrolase activity
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity

Cellular Component

None predicted.