Protein

MCA_02834_1

Length
373 amino acids

Gene name: PKAR

Description: cAMP-dependent protein kinase regulatory subunit

Browser: contigB:2480261-2481383-

RNA-seq: read pairs 7589, FPKM 250.7, percentile rank 90.5% (100% = highest expression)

Protein function

Annotation:PKARcAMP-dependent protein kinase regulatory subunit
KEGG:K04739PRKAR cAMP-dependent protein kinase regulator
EGGNOG:0PGW3PKARCAMP-dependent protein kinase regulatory subunit
SGD closest match:S000001295BCY1cAMP-dependent protein kinase regulatory subunit
CGD closest match:CAL0000190895BCY1cAMP-dependent protein kinase regulatory subunit

Protein alignments

%idAln lengthE-value
MIA_01466_169.28%3454e-158MIA_01466_1
A0A0J9X6F6_GEOCN66.10%2924e-137cAMP-dependent protein kinase regulatory subunit OS=Geotrichum candidum GN=BN980_GECA03s06258g PE=3 SV=1
UniRef50_A0A0J9X6F666.10%2927e-134cAMP-dependent protein kinase regulatory subunit n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X6F6_GEOCN
A0A167FU97_9ASCO64.26%2911e-121cAMP-dependent protein kinase regulatory subunit OS=Sugiyamaella lignohabitans GN=BCY1 PE=3 SV=1
KAPR_YARLI64.49%2768e-119cAMP-dependent protein kinase regulatory subunit OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PKAR PE=3 SV=1
A0A1E3PQM4_9ASCO58.39%2861e-115cAMP-dependent protein kinase regulatory subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_56492 PE=3 SV=1
A0A060T2H1_BLAAD57.89%2859e-116cAMP-dependent protein kinase regulatory subunit OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C28556g PE=3 SV=1
KAPR_YEAST55.28%2843e-109cAMP-dependent protein kinase regulatory subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BCY1 PE=1 SV=4
A0A1E4THX4_9ASCO59.50%2796e-105Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15843 PE=4 SV=1
KAPR_CANAL52.63%2855e-88cAMP-dependent protein kinase regulatory subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BCY1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0610

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 373

Detailed signature matches

  1. Family IPR012198
    cAMP-dependent protein kinase regulatory subunit
    1. PIRSF000548 (PK_reg...)
  2. Domain IPR014710
    RmlC-like jelly roll fold
    1. G3DSA:2.60.12...
  3. Domain IPR018490
    Cyclic nucleotide-binding-like
    1. SSF51206 (cAMP-bind...)
  4. Domain IPR000595
    Cyclic nucleotide-binding domain
    1. PF00027 (cNMP_binding)
    2. PS50042 (CNMP_BINDI...)
    3. SM00100 (cnmp_10)
  5. SITE IPR018488
    Cyclic nucleotide-binding, conserved site
    1. PS00888 (CNMP_BINDI...)
    2. PS00889 (CNMP_BINDI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PR00103 (CAMPKINASE)
  2. cd00038 (CAP_ED)
  3. mobidb-lite (disord...)

Residue annotation

  1. ligand binding sit...
  2. flexible hinge reg...
  3. ligand binding sit...
  4. flexible hinge reg...

Protein sequence

>MCA_02834_1
MADPFAQHPDDPSAPPSKSSPTSQSPTSQFAGFKSGFAEDSNSQFPPQQRAQASARPPHSGGSSLFSGAYSSSQSSTLPS
SGAGGAGNRFPMHFNANRRTSVSAESLNPAAFHGSLSEVKPTALTQSQLERINKSVAKNFLFSNLDEDSLHKVLGFLKEK
KVPAGEVIIKQGDEGDYFYIVESGSVEYAVDGKPVGKAEAGASFGELALMYNAPRAATVTALEDCVLWALDRVTFRKIIL
EKTATKRKMYGDFLKEVPILSSLDVYQLNKLADALNSETFEPGSVIIKEGDVGDKFYIVESGEAEVTKEGKGKVQDLSKG
SYFGEVALLNDLPRQATVSAVTKVRVVSLDKAGFQRLLGPVVDVLKKQDPTHN

GO term prediction

Biological Process

GO:0001932 regulation of protein phosphorylation

Molecular Function

GO:0008603 cAMP-dependent protein kinase regulator activity

Cellular Component

GO:0005952 cAMP-dependent protein kinase complex