Protein

MCA_02599_1

Length
467 amino acids

Description: subtilisin-like peptidase

Browser: contigB:1785752-1787156-

RNA-seq: read pairs 15, FPKM 0.4, percentile rank 6.3% (100% = highest expression)

Protein function

Annotation:subtilisin-like peptidase
KEGG:K01336E3.4.21.48 cerevisin [EC:3.4.21.48]
EGGNOG:0PGE1SUB6Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity (By similarity)
SGD closest match:S000000786PRB1Cerevisin
CGD closest match:CAL0000175297orf19.7196Proteinase B

Protein alignments

%idAln lengthE-value
A0A0J9YHD6_GEOCN45.21%4072e-97Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III OS=Geotrichum candidum GN=BN980_GECA01s02837g PE=3 SV=1
UniRef50_A0A0J9YHD645.21%4074e-94Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHD6_GEOCN
MIA_00133_144.97%3984e-96MIA_00133_1
A0A060T1Y8_BLAAD42.08%3855e-82ARAD1A03322p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03322g PE=3 SV=1
A0A167DJQ7_9ASCO40.75%4006e-80Proteinase B OS=Sugiyamaella lignohabitans GN=PRB1 PE=3 SV=1
A0A1E3PH86_9ASCO36.73%3926e-68Subtilisin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47354 PE=3 SV=1
A0A1D8PRH0_CANAL34.88%4102e-53Proteinase B OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7196 PE=3 SV=1
Q6C486_YARLI34.28%4232e-50YALI0E28875p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E28875g PE=3 SV=1
PRTB_YEAST34.07%4081e-48Cerevisin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRB1 PE=1 SV=1
A0A1E4THC1_9ASCO31.35%4211e-33Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_65053 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1020

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 467

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR010259
    Peptidase S8 propeptide/proteinase inhibitor I9
    1. PF05922 (Inhibitor_I9)
    2. G3DSA:3.30.70.80
  3. Domain IPR009020
    Protease propeptides/proteinase inhibitor I9
    1. SSF54897 (Protease ...)
  4. Domain IPR000209
    Peptidase S8/S53 domain
    1. G3DSA:3.40.50...
    2. PF00082 (Peptidase_S8)
    3. SSF52743 (Subtilisi...)
  5. Domain IPR034193
    Proteinase K-like catalytic domain
    1. cd04077 (Peptidases...)
  6. SITE IPR023827
    Peptidase S8, subtilisin, Asp-active site
    1. PS00136 (SUBTILASE_ASP)
  7. SITE IPR022398
    Peptidase S8, subtilisin, His-active site
    1. PS00137 (SUBTILASE_HIS)
  8. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM
  8. TRANSMEMBRANE (Tran...)

Residue annotation

  1. calcium binding si...
  2. active site cd04077
  3. catalytic triad cd...
  4. calcium binding si...

Protein sequence

>MCA_02599_1
MPSLCKYIQLTIPILFISSVEGVPLPSSSSSFKAVCESTSVNKRSEELQPALPSSYPFKIIPGPAGVYKRKADLDARSSS
PYSNYIVMFKETASSKNRDLHKKWLEGVIQKRSDGIFGFRKFFGKDETIGGIKGFFPSKKGYYGTFSKAEIRHIESNPDV
AYVELDHKDKIQYTERHSPVPWGLSRISRHDYPIQDTPDMDDYAFKYPAGSNVTIYVIDSGVSDTHKELQGKVRHGPNFV
DDNNKDPNGHGTHIAGIAAGRMVGVAPGADVVSVKVINEANAAPISSTIQAIEWVIEDVKANPWRKAVINYSAIGPISRA
RQDAIESAIRAGIMVVTGAGNDSQDSCNFGPANLGQSHSSLITVAAIDYENRPAPFTNYGKCVSVYAPGVFILSASHLFD
DAYVYMSGTSMAAPHVTGLVAYYWSLRPTYKKLKIKQLIINSNRDKVVGNLHDTPNKIAFNKITENF

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.