Protein
MCA_02579_1
Length
214 amino acids
Gene name: EGD2
Description: Nascent polypeptide-associated complex subunit alpha
Browser: contigB:1707176-1707821-
RNA-seq: read pairs 18198, FPKM 1045.8, percentile rank 96.7% (100% = highest expression)
Protein function
| Annotation: | EGD2 | Nascent polypeptide-associated complex subunit alpha | |
|---|---|---|---|
| KEGG: | K03626 | EGD2 | nascent polypeptide-associated complex subunit alpha |
| EGGNOG: | 0PN4Z | EGD2 | Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Egd2 may also be involved in transcription regulation (By similarity) |
| SGD closest match: | S000001236 | EGD2 | Nascent polypeptide-associated complex subunit alpha |
| CGD closest match: | CAL0000185584 | EGD2 | Nascent polypeptide-associated complex subunit alpha |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01038_1 | 48.63% | 183 | 1e-37 | MIA_01038_1 |
| UniRef50_A0A0V0UDQ2 | 36.63% | 172 | 4e-20 | Nascent polypeptide-associated complex subunit alpha n=4 Tax=Trichinella TaxID=6333 RepID=A0A0V0UDQ2_9BILA |
| A0A0J9X794_GEOCN | 48.81% | 168 | 2e-21 | Similar to Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation OS=Geotrichum candidum GN=BN980_GECA04s03442g PE=4 SV=1 |
| A0A1E4TBQ1_9ASCO | 35.76% | 165 | 7e-20 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28061 PE=4 SV=1 |
| NACA_CANAL | 40.46% | 173 | 1e-19 | Nascent polypeptide-associated complex subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=EGD2 PE=3 SV=1 |
| A0A167EIA7_9ASCO | 38.64% | 176 | 6e-19 | Egd2p OS=Sugiyamaella lignohabitans GN=EGD2 PE=4 SV=1 |
| A0A060T643_BLAAD | 37.36% | 174 | 1e-18 | ARAD1B16434p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B16434g PE=4 SV=1 |
| NACA_YEAST | 34.12% | 170 | 3e-16 | Nascent polypeptide-associated complex subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EGD2 PE=1 SV=3 |
| NACA_YARLI | 37.02% | 181 | 1e-14 | Nascent polypeptide-associated complex subunit alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=EGD2 PE=3 SV=1 |
| A0A1E3PG51_9ASCO | 50.00% | 40 | 2e-07 | Nascent polypeptide-associated complex, alpha subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27346 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0900
Protein family membership
Domains and repeats
-
Domain
1
20
40
60
80
100
120
140
160
180
200
214
Detailed signature matches
-
-
PIRSF015901 (NAC_alpha)
-
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_02579_1 MSDRIEEIVDDSTKVEEEQHTHSHEHGHDHEHDHEHDHEGEIPEGATISVYSKAEKKARKALVKMGLKKVPGINRVVFRN SQDLHFVIARPDVYRSGPTTFIVFGEIKAEDMGRYAREAQAQQAAAAAAAAAGETPKDPESITADLEAAAAAGADKQEEE EEDDVTDEQVLATGITKEDFEMIKDQTLKSNGKILKALKENDNDVVNTIVALAE
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
GO:0005854 nascent polypeptide-associated complex