MCA_02481_1

Protein

Length

2,166 amino acids

Gene name: DNA2

Description: DNA replication ATP-dependent helicase/nuclease DNA2

Browser: contigB:1439873-1446374+

RNA-seq: read pairs 503, FPKM 2.9, percentile rank 13.5% (100% = highest expression)

Protein function

Annotation:		DNA2	DNA replication ATP-dependent helicase/nuclease DNA2
KEGG:	K10742	DNA2	DNA replication ATP-dependent helicase Dna2 [EC:3.6.4.12]
EGGNOG:	0PHGW	DNA2	DNA. Replication
SGD closest match:	S000001207	DNA2	DNA replication ATP-dependent helicase/nuclease DNA2
CGD closest match:	CAL0000193143	DNA2	Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease

Protein alignments

	%id	Aln length	E-value
MIA_01493_1	46.65%	1119	0.0	MIA_01493_1
A0A0J9XAJ8_GEOCN	43.34%	1096	0.0	Similar to Saccharomyces cerevisiae YHR164C DNA2 Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities OS=Geotrichum candidum GN=BN980_GECA08s00164g PE=4 SV=1
UniRef50_A0A0J9XAJ8	43.34%	1096	0.0	Similar to Saccharomyces cerevisiae YHR164C DNA2 Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAJ8_GEOCN
A0A060T4V5_BLAAD	38.83%	1092	0.0	ARAD1C44616p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C44616g PE=4 SV=1
Q6C3N5_YARLI	38.08%	1040	0.0	YALI0E33377p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33377g PE=4 SV=2
A0A167CWN1_9ASCO	38.95%	968	0.0	Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 OS=Sugiyamaella lignohabitans GN=DNA2 PE=4 SV=1
A0A1D8PPB3_CANAL	34.05%	1028	4e-171	Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DNA2 PE=4 SV=1
DNA2_YEAST	34.36%	1071	3e-159	DNA replication ATP-dependent helicase/nuclease DNA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DNA2 PE=1 SV=1
A0A1E3PH35_9ASCO	30.23%	483	8e-36	DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26851 PE=4 SV=1
A0A1E4TKE7_9ASCO	31.16%	276	4e-18	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_84103 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0333

Protein family membership

None predicted.

Domains and repeats

Domain
978 - 1,193
DNA replication factor Dna2, N-terminal (IPR014808)
1,553 - 1,781
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,811 - 1,954
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2166

Detailed signature matches

IPR014808

DNA replication factor Dna2, N-terminal
1. PF08696 (Dna2)
  
  978 - 1,193
  
  Pfam
  PF08696 (Dna2)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,553 - 1,781
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,811 - 1,954
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)

no IPR

Unintegrated signatures

Coil

1,327 - 1,347

COILS
Coil (Coil)

2,164 - 2,166

COILS
Coil (Coil)
G3DSA:3.40.50...

1,551 - 1,764

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

1,765 - 1,962

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PF13086 (AAA_11)

1,655 - 1,727

Pfam
PF13086 (AAA_11)
PF13087 (AAA_12)

1,735 - 1,947

Pfam
PF13087 (AAA_12)
cd00009 (AAA)

1,560 - 1,605

CDD
cd00009 (AAA)
mobidb-lite (disord...)

2,093 - 2,166

MobiDB Lite
mobidb-lite (disorder_prediction)

378 - 418

MobiDB Lite
mobidb-lite (disorder_prediction)

1,981 - 2,080

MobiDB Lite
mobidb-lite (disorder_prediction)

203 - 245

MobiDB Lite
mobidb-lite (disorder_prediction)

124 - 184

MobiDB Lite
mobidb-lite (disorder_prediction)

482 - 542

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 101

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A motif cd0...

1,580G

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,581M

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,582P

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,583G

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,584T

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,585G

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,586K

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)

1,587T

Walker A motif
1,580G, 1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T
CDD
cd00009 (AAA)
ATP binding site c...

1,581M

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,582P

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,583G

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,584T

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,585G

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,586K

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,587T

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

1,588T

ATP binding site
1,581M, 1,582P, 1,583G, 1,584T, 1,585G, 1,586K, 1,587T, 1,588T
CDD
cd00009 (AAA)

Protein sequence

>MCA_02481_1
MKDGEKDQSTKYKKIKRMKIRPRASTNTSNTLTHQTTLPINNLKNASTSAAIPRIQKPTSKIIEAHNKEVKAASEPPKSS
SRNPSGSADITSTYTPILPQNTTTNLANKLSAYLRNETSISVNVQDDEDNNYNSHLESRSRNLQKKFDKSSNHGNSSTLE
TFKVPSNSKPTNNEENQSLQKSAQSKAIEELLLATPKKPVIGWNTNSSPFEGGSSPDKHSYFNVSASQNSNDSSTHKTAP
DNSSDIDMDFEDRENEYLSDPGEALDSIYYSNTNHKKLTKNAYDNKLPFNSISQKPITIPDDQKTHTSIVNNLIKARPYR
SDISFDSTTSTSYNLHNGAVKFINNNKTKNIMLPNHVNQLMSPESIKRSLKLSARPATIPSLSGQTNEHESDSLNLNRHV
RDFTPRSPVNSKRRKTNFTTGILDYNESSHSNSFSTSKSHCISEKSERLKSLVDCLQHNDNNQAQKNDSDYEMDTNKESY
SYNRQENESADKPSLQSQDFSKQNQSNSATPTPANKAKSIAGPGMNTEGSALAKSQEEIEEEDSFFNASLPLMSSPIYKD
FNQIETLNNNKALENHDEPNPKSTEIPEIPLPPISTLANKLGSAKSPILLGSSSPVKNVNFSFPSSDDVPVELLEEAFNE
LNGIRSGTNSMVGSAIINSALGNPQSNLQESNIDDRKVNENANTFKEVKEVHIESSNMRIQTRISDIEDIAFNSSSSASS
QPHKRTLVAASTLSRASQLSANNSTMDNTVIGTSFAQDRNKNAAARSTTTPNYKGLQHIDIGIEKTVTGTSTPIAADQTK
IGVSTPLMGSFGADLDLELDDDWDEDWLSEKADESIIMGLSDMSKSKSLNKDVQVPIQQQKATRSAAATIEQSTLSTTTP
IDSFSKSEILQKNASLLTVQNEPIDFRTLPTSRSRMSTTVTAPTELDIKCLIKNPRMHRLAVTHVQIRDYLTKNFRGRDI
TKTEVHVKAVGQNKIPVSIILRDDWIDCTPSVDDMVHVVLSSTFTPSSSDKNNTLVPDSTFVIDGKNNYLIICPDTLVSC
TSVTESVKCTRKVVLKSLIRPLDGPTTEPLIYGTLIHIIFQQSLAEYDFSPKFMHRNAIRLVNESLEDFVLLNISQQEAV
AYILSKLPKIREWASKYVRSPKFLAKNKVPNNDVGQLSQAQRFKVGITEIDEIEEDVKIPTYGLNGKIDVSCKAVVLPQS
SFNNNAEPELVPIEIKTSKTQYDSISHQGQTKLYTLLLAEKYGFDEGLKYGLLVYSEDGATVPVEPTASHLKGLLIKRNE
IAVALRDKAQSLPQMVSDKVLCSYCEFFDSCAVYNNITEGGSKDDVAAELKDMYQEVIKHIGEIEKEFFKKWINLLAFEE
REYSGFTKELWTMTSKERESLGRCFARVKLAHYYDQPDSSSSGKYTRRRYKLERANFEVDGPFFSEDSYISVGETVLISE
EDTNVVLCKGTITAIRRKYLYIDTSKNLMLLIKNHLMKHRSFKNSQHINEEDVTLRIDHDQFMPSLSLARRNIVVLVSSG
LSNVAKLRDILLHNYPPKFLFKPPPYTIPGLSDGARKLNPDQQNAINQVLSANDFTLILGMPGTGKTTTIAALVETLVSL
GKTVLLTSYTHSAVDNILLKLNTDPSNVLRLGWHLSIHPEARKFSVGSANKQVTNKEEMEKVYMQPPIVGVTCLGITHWL
LSQRQFDYCIVDEASQVTLPTCLGPIMLAEKFVLVGDHYQLSPLVKSSDALEGGLDESLFKILNDKWPQSIVNLEHQYRM
CEDIMVLSNKLIYEGKLKCGTEEISNQSLNIPNKEAIESWKPESISKENDWLETVLSLNNKVIFLNTDQISTARERNVDE
RLFNEAEANIVRIIVEAMCSSGVPEPSLGVISVYRSQLKLLNKLLNNRKGVEQLTADRFQGRDKDCVIISLVRSNDKNQI
GDLLKDWRRLNVAFTRAKSKLIIVGSRTTLDTHPAMTAFLNLIDEHSWAYTLPPNAINLYNIPSSSDENTQETQETQENE
NLESDMDSQLPDSSSDSQSKSNNFRNQGNNNNSNSSSSDISTPTHSNKSTNSIVPSSSSKKLSSLSKARYGPGQRALSSS
MSPFAREVLAESGTLSLPTSPSTSSLPANSLARSNTTPGASKVTRPSTFPRNNNTKRFVGNPNSSFTSPLINRSSSNRGG
SNQYQK

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_02481_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component