Protein
MCA_02404_1
Length
450 amino acids
Gene name: VCX1
Description: vacuolar membrane antiporter with calcium/H+ and potassium/H+ exchange activity
Browser: contigB:1179912-1181265+
RNA-seq: read pairs 12897, FPKM 353.3, percentile rank 92.8% (100% = highest expression)
Protein function
| Annotation: | VCX1 | vacuolar membrane antiporter with calcium/H+ and potassium/H+ exchange activity | |
|---|---|---|---|
| KEGG: | K07300 | chaA | Ca2+:H+ antiporter |
| EGGNOG: | 0PIFK | transporter | |
| SGD closest match: | S000002286 | VCX1 | Vacuolar calcium ion transporter |
| CGD closest match: | CAL0000184577 | VCX1 | Vcx1p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01612_1 | 73.73% | 434 | 0.0 | MIA_01612_1 |
| A0A0J9X8Q6_GEOCN | 65.44% | 408 | 4e-161 | Similar to Saccharomyces cerevisiae YDL128W VCX1 Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity OS=Geotrichum candidum GN=BN980_GECA06s00263g PE=3 SV=1 |
| Q6CF88_YARLI | 63.21% | 405 | 2e-154 | YALI0B09273p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B09273g PE=3 SV=2 |
| A0A167DAV8_9ASCO | 61.19% | 402 | 1e-146 | Vcx1p OS=Sugiyamaella lignohabitans GN=VCX1 PE=3 SV=1 |
| A0A060T6V6_BLAAD | 61.35% | 401 | 2e-139 | ARAD1B22440p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B22440g PE=3 SV=1 |
| A0A1E3PED4_9ASCO | 62.19% | 402 | 5e-135 | Calcium/proton exchanger OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84343 PE=3 SV=1 |
| Q59QB4_CANAL | 59.35% | 401 | 3e-132 | Vcx1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VCX1 PE=3 SV=1 |
| UniRef50_W1Q6U4 | 52.76% | 417 | 5e-116 | Ca2+/H+ antiporter n=6 Tax=saccharomyceta TaxID=716545 RepID=W1Q6U4_OGAPD |
| VCX1_YEAST | 52.35% | 405 | 9e-113 | Vacuolar calcium ion transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VCX1 PE=1 SV=1 |
| A0A1E4TBM6_9ASCO | 51.60% | 405 | 3e-111 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_134275 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1131
Protein family membership
- Calcium/proton exchanger CAX (IPR004798)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
400
450
450
Detailed signature matches
-
-
PF01699 (Na_Ca_ex)
-
no IPR
Unintegrated signatures
-
CYTOPLASMIC_D... (C...)
-
NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
-
mobidb-lite (disord...)
Protein sequence
>MCA_02404_1 MSSYDRNLHSSSDGFHYIMGKAKLFKVGNPTLSKLQSKSSSALHKIQLVLTSSYVNVLLIFVPLGILAYKLGWGSTPVFV LNFLAIVPLAALLGYATEEIAVHVGETVGGLLNATFGNAVELIVAIVALARGEIRIVQTSMLGSILSNTLLVLGSCFISG GYNRIQQKFNATVAQTMSALMALAVISLLIPAAFNSSFPHPTNPVKPTDPSLPTPADPADKAVLNVSHGTSIILLIIYVF YLFFQLKTHATYFSSMDEESQAGAPITAAANGSSSTNDERSPLLGSSSEEEEEEEESTLNTYEALGLLTLVTIVVSFCAD YMVDSIDDIVASTGVSKTFIGVILIPIVGNAAEHVTAIVVATKDKMDLAVGVAIGSSMQIALFLTPFCVILGWIIGQPMS LLFTTFETCVLFVTVLMMNYIVQDGESNWLEGTMLVGTYFVVAIAFWNYP
GO term prediction
Biological Process
GO:0006816 calcium ion transport
GO:0055085 transmembrane transport
Molecular Function
GO:0015369 calcium:proton antiporter activity
Cellular Component
GO:0016021 integral component of membrane