Protein
MCA_02310_1
Length
549 amino acids
Gene name: SWC4
Description: SWR1-complex protein 4
Browser: contigB:902883-904675+
RNA-seq: read pairs 1285, FPKM 28.9, percentile rank 51.7% (100% = highest expression)
Protein function
| Annotation: | SWC4 | SWR1-complex protein 4 | |
|---|---|---|---|
| KEGG: | K11324 | DMAP1 | DNA methyltransferase 1-associated protein 1 |
| EGGNOG: | 0PK52 | SWC4 | Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair |
| SGD closest match: | S000003234 | SWC4 | SWR1-complex protein 4 |
| CGD closest match: | CAL0000199374 | SWC4 | SWR1-complex protein 4 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01151_1 | 62.96% | 351 | 7e-128 | MIA_01151_1 |
| A0A0J9XBV5_GEOCN | 53.72% | 363 | 2e-99 | Similar to Saccharomyces cerevisiae YGR002C SWC4 Component of the Swr1p complex that incorporates Htz1p into chromatin OS=Geotrichum candidum GN=BN980_GECA08s04256g PE=4 SV=1 |
| UniRef50_A0A0J9XBV5 | 53.72% | 363 | 3e-96 | Similar to Saccharomyces cerevisiae YGR002C SWC4 Component of the Swr1p complex that incorporates Htz1p into chromatin n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XBV5_GEOCN |
| A0A060TDI5_BLAAD | 42.19% | 384 | 1e-69 | ARAD1D00594p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00594g PE=4 SV=1 |
| SWC4_YARLI | 43.01% | 365 | 3e-68 | SWR1-complex protein 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SWC4 PE=3 SV=1 |
| A0A1E4TDI4_9ASCO | 38.62% | 334 | 5e-52 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_58621 PE=4 SV=1 |
| SWC4_YEAST | 37.50% | 368 | 3e-48 | SWR1-complex protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWC4 PE=1 SV=1 |
| A0A161HK67_9ASCO | 42.77% | 159 | 2e-40 | Swc4p OS=Sugiyamaella lignohabitans GN=SWC4 PE=4 SV=1 |
| A0A1E3PTS2_9ASCO | 37.79% | 299 | 1e-35 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68824 PE=4 SV=1 |
| SWC4_CANAL | 36.41% | 206 | 2e-18 | SWR1-complex protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SWC4 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0850
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
400
450
500
549
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_02310_1 MASDFRDVLDIPERTQPAHPIKRHKSDAPVRRMEGMQRELYSLLGENTPPVAIFENRFKEKPSWNQKAVPWSWVPFTNAG RKDGLTLHHWVRGRHTVDNEEYAFAKFNQKLSIPQFSKEDYENHLQDPEWTYEETCYLFDMCQDYDLRWIVIHDRYDFQQ AVRDAHPDQKPSTPVKPEESLSTEDLPTESIKTAPITYSDPKIRTIEDLKARFYDVGRKVLKFRQARGEPSGPSQDVLYK QMKYSKENEIIRKKHLEQLLARSPAEIAEEEALVLESRKLEAAAETLLLERAEVLKLLNAPSPTIKTAEYQTSQGLVQLT NQLLSDKSRKRKDPSGATIPDSTSPSPATPSAAEAAAATSAPAKPQAQQETAAASATASGRKGEKAAAAAAPELKKSGSS TKIKTEEEAASTSTASASNTKTKKGKREKEPTSSKKGHLTGSQAIAAAIHRKLSSKEEAAYGLSYHEKLNTGVYLRSSKI TNYRPSQQAKIIQVLAELGIPSRPVMPTARVTSKFDSLQQSISVLLEAKKQADKLETEIKVLKAQKEMK
GO term prediction
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Molecular Function
None predicted.
Cellular Component
GO:0005634 nucleus