Protein

MCA_02267_1

Length
443 amino acids

Gene name: TRM11

Description: tRNA (guanine(10)-N2)-methyltransferase

Browser: contigB:757609-759315+

RNA-seq: read pairs 333, FPKM 9.3, percentile rank 24.7% (100% = highest expression)

Protein function

Annotation:TRM11tRNA (guanine(10)-N2)-methyltransferase
KEGG:K15430TRM11 tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]
EGGNOG:0PFNQPGUG_04212RNA Methylase
SGD closest match:S000005484TRM11tRNA (guanine(10)-N2)-methyltransferase
CGD closest match:CAL0000185296orf19.5987tRNA (Guanine-N2-)-methyltransferase

Protein alignments

%idAln lengthE-value
MIA_03854_174.77%4320.0MIA_03854_1
A0A0J9X4I5_GEOCN66.89%4410.0Similar to Saccharomyces cerevisiae YOL124C TRM11 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p) OS=Geotrichum candidum GN=BN980_GECA02s04971g PE=4 SV=1
A0A1E3PPQ2_9ASCO58.89%4330.0Putative ribonuclease methylating protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_22259 PE=4 SV=1
A0A167FHC9_9ASCO58.56%4440.0Trm11p OS=Sugiyamaella lignohabitans GN=TRM11 PE=4 SV=1
A0A060T4X0_BLAAD59.49%4320.0ARAD1C06424p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C06424g PE=4 SV=1
Q6CC03_YARLI54.97%4331e-176YALI0C13882p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C13882g PE=4 SV=1
UniRef50_Q6CC0354.97%4333e-173YALI0C13882p n=5 Tax=Saccharomycetales TaxID=4892 RepID=Q6CC03_YARLI
Q5ANB6_CANAL50.34%4431e-158tRNA (Guanine-N2-)-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5987 PE=4 SV=1
TRM11_YEAST52.78%4323e-156tRNA (guanine(10)-N2)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRM11 PE=1 SV=1
A0A1E4TJ19_9ASCO50.69%4321e-155Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_322 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1771

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 443

Detailed signature matches

  1. Family IPR016691
    tRNA guanosine-2'-O-methyltransferase, TRM11
    1. PS51627 (SAM_MT_TRM11)
  2. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
  3. Domain IPR000241
    Putative RNA methylase domain
    1. PF01170 (UPF0020)
  4. SITE IPR002052
    DNA methylase, N-6 adenine-specific, conserved site
    1. PS00092 (N6_MTASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. PIRSF017259 (tRNA_M...)
  3. PR00507 (N12N6MTFRASE)
  4. cd02440 (AdoMet_MTases)

Residue annotation

  1. S-adenosylmethioni...

Protein sequence

>MCA_02267_1
MKFLILLAQYHLDFRLTELESLADFHGLNVDFSNYTDKDPFLIVELESAEDARKLVEKSILCRSVYELYGHGTTIEELHQ
QTKACESQWEKYKDANVSFKFEFVSFMGSRDKRKQLEIIESFAFMDLEGPIRMKKPDQTFSIIEEYKVIDRKPEVEPRRV
WFGRFITNSDRSAMDRMDLRKRKYIGTTTFDAELALVSCNIAQLTDGKIMYDPFAGTGSFLVAAGHMGALACGSDIDVRM
LRGDGKNRTIDANFKQYGTYNKYIDVMTMDFTHNAFRNNFKFDAIICDPPYGVREGLKVLGAKNEEKFVGKEDVMIDGVP
AHLRKDYVPTKKPYEFNALLDDLLQFSADHLVEGGRLCFWMPVANDDFKEHHIPLHPELKLLSCCIQDFNKWSRRLLCYK
RRPAGEIGESQYVTGISAEEFREKYFRGFSKRGGSKKIDANQR

GO term prediction

Biological Process

GO:0032259 methylation

Molecular Function

GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity

Cellular Component

None predicted.