Protein

MCA_02250_1

Length
590 amino acids

Gene name: FRS1

Description: Phenylalanine--tRNA ligase beta subunit

Browser: contigB:714501-716428-

RNA-seq: read pairs 4711, FPKM 98.5, percentile rank 78.4% (100% = highest expression)

Protein function

Annotation:FRS1Phenylalanine--tRNA ligase beta subunit
KEGG:K01890FARSB phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
EGGNOG:0PGUMFRS1Phenylalanyl-tRNA synthetase, beta
SGD closest match:S000004050FRS1Phenylalanine--tRNA ligase beta subunit
CGD closest match:CAL0000190210FRS1Phenylalanine--tRNA ligase subunit beta

Protein alignments

%idAln lengthE-value
MIA_04029_183.16%5940.0MIA_04029_1
A0A0J9X6I0_GEOCN77.83%5910.0Similar to Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA03s07292g PE=4 SV=1
A0A167EGI9_9ASCO67.90%5950.0Phenylalanine--tRNA ligase subunit beta OS=Sugiyamaella lignohabitans GN=FRS1 PE=4 SV=1
A0A060T2S1_BLAAD68.01%5940.0ARAD1C27456p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C27456g PE=4 SV=1
A0A1E3PDS1_9ASCO65.79%6050.0Henylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53227 PE=4 SV=1
Q6C4X4_YARLI65.71%5950.0YALI0E22979p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E22979g PE=4 SV=1
A0A1D8PS16_CANAL64.76%5930.0Phenylalanine--tRNA ligase subunit beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FRS1 PE=4 SV=1
UniRef50_O1343264.76%5930.0Phenylalanine--tRNA ligase beta subunit n=209 Tax=Eukaryota TaxID=2759 RepID=SYFB_CANAX
SYFB_YEAST59.77%5990.0Phenylalanine--tRNA ligase beta subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRS1 PE=1 SV=3
A0A1E4TB98_9ASCO61.45%5940.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133023 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1927

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 590

Detailed signature matches

  1. Family IPR004531
    Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic
    1. TIGR00471
  2. Domain IPR009061
    Putative DNA-binding domain
    1. SSF46955 (Putative ...)
  3. Domain IPR005146
    B3/B4 tRNA-binding domain
    1. SM00873 (B3_4_2)
    2. PF03483 (B3_4)
  4. Domain IPR020825
    Phenylalanyl-tRNA synthetase, B3/B4
    1. G3DSA:3.50.40.10
  5. Domain IPR005147
    tRNA synthetase, B5-domain
    1. PF03484 (B5)
    2. SM00874 (B5_2)
    3. PS51483 (B5)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.56.10
  2. G3DSA:3.30.93...
  3. SSF55681 (Class II ...)
  4. cd00769 (PheRS_beta...)

Residue annotation

  1. dimer interface cd...
  2. motif 1 cd00769
  3. motif 3 cd00769
  4. motif 2 cd00769

Protein sequence

>MCA_02250_1
MPTISVDKGDLYKSLGREYTTKEFDELCFQFGIELDEDTSEGDLQPGERPQLKIEIPANRYDMLCYEGISRALRIFLGLD
KLPVYKLVKPSKLITVTVDKNTESVRPYVASAILRNITFDKKRYDSFISLQDKLHTNLCRNRSLVAIGTHDLDKVKGPIT
YEARKPENIKFTPLNQTKEMNGVELMEFYEKDKNLGKYLHLIRDSPVYPAFYDADGHVLSLPPIINSERTKITLDTKNVF
IDLTATDKTKLEIVVNQLIAMFSEYCEEPFTVEPVEIISEHNGESRVEPNIEERQTTAEISYINSCLGLDLTAEEICGHL
TKLSLNAKPSKDANLIDVTIPITRPDILHQCDIMEDVAIGYGYDNLKKTFPADSYTIAEALPINKVSDIVRREVAMCGPW
LEVMPLTLCSHDENFKFLRRKDEGNAVHLANPKTLEYQVVRTSLLPGILKTIRENRKHSLPITVFEAADVVFKDEKLERK
AFNRRHFAAIYAGQTSGFETVHGLLDRIMAMLRVSWLQKEDGSKKRGYWIEPNNSETFFPGRGATVYFRSKDGEEAQAIG
EMGIVHPEVMANFEIPYVGSSLELNLEVFL

GO term prediction

Biological Process

GO:0006432 phenylalanyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm