Protein

MCA_02204_1

Length
450 amino acids

Gene name: PMI1

Description: Mannose-6-phosphate isomerase

Browser: contigB:582336-583689+

RNA-seq: read pairs 2593, FPKM 71.0, percentile rank 73.0% (100% = highest expression)

Protein function

Annotation:PMI1Mannose-6-phosphate isomerase
KEGG:K01809manA mannose-6-phosphate isomerase [EC:5.3.1.8]
EGGNOG:0PFMAPMI1mannose-6-phosphate isomerase
SGD closest match:S000000805PMI40Mannose-6-phosphate isomerase
CGD closest match:CAL0000189115PMI1Mannose-6-phosphate isomerase

Protein alignments

%idAln lengthE-value
MIA_04008_171.02%4520.0MIA_04008_1
A0A0J9X4H0_GEOCN60.53%4560.0Mannose-6-phosphate isomerase OS=Geotrichum candidum GN=BN980_GECA01s09426g PE=3 SV=1
A0A060T5V6_BLAAD56.88%4439e-172Mannose-6-phosphate isomerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C08404g PE=3 SV=1
A0A1E3PCP7_9ASCO57.05%4476e-168Mannose-6-phosphate isomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84380 PE=3 SV=1
MPI_CANAL55.70%4567e-161Mannose-6-phosphate isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PMI1 PE=1 SV=2
A0A167E236_9ASCO57.11%4294e-158Mannose-6-phosphate isomerase OS=Sugiyamaella lignohabitans GN=PMI40 PE=3 SV=1
MPI_YEAST56.03%4483e-156Mannose-6-phosphate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMI40 PE=1 SV=4
UniRef50_P2995256.03%4487e-153Mannose-6-phosphate isomerase n=87 Tax=Saccharomycetales TaxID=4892 RepID=MPI_YEAST
Q6CE59_YARLI53.83%4444e-154Mannose-6-phosphate isomerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B18348g PE=3 SV=1
A0A1E4TLH2_9ASCO57.32%3966e-140Mannose-6-phosphate isomerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1207 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3943
Predicted cleavage: 31

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 450

Detailed signature matches

  1. Family IPR001250
    Mannose-6-phosphate isomerase, type I
    1. TIGR00218
    2. PF01238 (PMI_typeI)
  2. Family IPR016305
    Mannose-6-phosphate isomerase
    1. PR00714 (MAN6PISMRASE)
    2. PIRSF001480 (PMI)
  3. Domain IPR014710
    RmlC-like jelly roll fold
    1. G3DSA:2.60.12...
  4. Domain IPR011051
    RmlC-like cupin domain
    1. SSF51182 (RmlC-like...)
  5. SITE IPR018050
    Phosphomannose isomerase, type I, conserved site
    1. PS00966 (PMI_I_2)
    2. PS00965 (PMI_I_1)

Protein sequence

>MCA_02204_1
MSSYNLVKLICGVQSYDWGKLGSSSAVARFAAVADPSFTIDESKPYAELWMGSHPSVPSMAVTPSGKVSLRTVLSDHPEL
LGATISEKFGAGELPFLFKVLSIRKALSIQAHPDKALARQLHSSDPKNYPDDNHKPEMAIAITAFEGFCGFRPLAEIAAL
LRNVPEFVELIGGQEGADEFINNIDTSENIEEGSSTDIKNRKSLQNLFSRVMNASQEAISKCTNALVERAQTEGESFGYG
KDNDTSSGSFGKPLAELIIKLNKQFPEDIGLFCGGMMLNYVTLTPGQAMFLRAKDPHAYISGDIMECMAASDNVVRAGFT
PKFKDVTNLVSMLTYSYDPVEKQKMVPEEYSLAESSTESAKNILYNPPIDEFAVVQTKLQDSASTSFKPLNGPSILIVTN
GSISIKTKETTLNMETGEVVFIGAGTGVELSNSGSEEAITYTAIVEVASA

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0009298 GDP-mannose biosynthetic process

Molecular Function

GO:0004476 mannose-6-phosphate isomerase activity
GO:0008270 zinc ion binding

Cellular Component

None predicted.