Protein

MCA_02146_1

Length
808 amino acids

Description: Putative GTPase activating protein (GAP)

Browser: contigB:354745-357172+

RNA-seq: read pairs 2251, FPKM 34.4, percentile rank 56.6% (100% = highest expression)

Protein function

Annotation:Putative GTPase activating protein (GAP)
KEGG:K05767IQGAP2_3 Ras GTPase-activating-like protein IQGAP2/3
EGGNOG:0PGAJGAP1GTPase-activating protein
SGD closest match:S000005441IRA2Inhibitory regulator protein IRA2
CGD closest match:CAL0000175167IQG1Ras GTPase-activating-like protein IQG1

Protein alignments

%idAln lengthE-value
MIA_03837_183.00%8060.0MIA_03837_1
A0A060T599_BLAAD69.62%7800.0ARAD1B05698p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B05698g PE=4 SV=1
A0A0J9X601_GEOCN69.74%7700.0Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA03s03981g PE=4 SV=1
A0A167D7A0_9ASCO68.19%7860.0Ira1p OS=Sugiyamaella lignohabitans GN=IRA1 PE=4 SV=1
UniRef50_W0TYM258.85%8020.0YALI0E09086p n=3 Tax=Dipodascaceae TaxID=34353 RepID=W0TYM2_YARLI
W0TYM2_YARLI58.85%8020.0YALI0E09086p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E09086g PE=4 SV=1
A0A1E4TMB3_9ASCO41.17%6004e-148Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15563 PE=4 SV=1
A0A1E3PEI1_9ASCO49.40%5021e-144Rho GTPase activation protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83928 PE=4 SV=1
IQG1_CANAL20.94%5113e-18Ras GTPase-activating-like protein IQG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IQG1 PE=1 SV=2
IRA2_YEAST25.90%2512e-15Inhibitory regulator protein IRA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRA2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1778
Predicted cleavage: 48

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 808

Detailed signature matches

  1. Domain IPR008936
    Rho GTPase activation protein
    1. SSF48350 (GTPase ac...)
  2. Domain IPR001936
    Ras GTPase-activating protein
    1. PS50018 (RAS_GTPASE...)
    2. PF00616 (RasGAP)
    3. SM00323 (RasGAP_2)
  3. Domain IPR000593
    RasGAP protein, C-terminal
    1. PF03836 (RasGAP_C)
  4. SITE IPR023152
    Ras GTPase-activating protein, conserved site
    1. PS00509 (RAS_GTPASE...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.28...
  3. G3DSA:1.10.50...
  4. SSF143885 (RGC doma...)
  5. cd05132 (RasGAP_GAPA)
  6. mobidb-lite (disord...)

Residue annotation

  1. putative RAS inter...

Protein sequence

>MCA_02146_1
MSDLPVPTPRRPPGGSATPNSATSPASNGGVPMSAGSSNPNRQSKRYSVAALYMSMGGVDRDDDIDDELAKAQKLLRELK
TNISEQSKKNFLLEKDVRYLDSRIALLIQNRMGIEEQNEVASRLEPDSNAAPDSKDGDQYFPDRKKTELYGNLFFLLQSE
PKNIAVLCRLVSMAEIDSLLQTVMFTIYGNQYEQREEHLLLSMFQAVLAHQFENATEFSSLLRANTPVSRMMTTYTRRGP
GQTYLRSSLSSSLNKIIEQKDLNLEINPLKVYDELMDSSEDPFLSPQNITPDDAFKNPQVQALIQPRLVQLDTLANDLLN
TIIASLQQVPYGIRWICKQIRLLTRRKYPTASETAVCSLIGAFFFLRFVNPAIVTPQAYMLVDKLPSDNSRRILTLIAKM
LQNLANKPSYSKEPYMSNLAAFVSSNRARINEFLNDLCEVPDFYESLEMDQYVALSKKDLKLNITLNEIFGMHSLLEKYR
DGVVSSSDSHLAILLQDLQKAPPLVPRSMNGTMELHLFNRWETEVGDIDNNLDFLRADVIFMEAKTLMINIIRGFPTGHS
ILQKPFDLHRIADFAATNNEPGIVKRGIKALDLLNEIEDSNSGDYDLLVSEVEYELNQLGSLKESVEQEARSLQDVYTII
REHNEYLRSQLDTYRSYLSNVRQYTTGGAKSAGPVGVSILDSSGKEVTPSSSKVRGITKVKTLKQPKQRIIHKKYTIQQL
QRDAIVTEWRLPTSRMGNLFISIVSPTPGTFVLSLVMKGRPQPLFILDLKLDDLLEMRDKGMESLDLQCLIMNVKNLQGL
LTKDFKKR

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0043087 regulation of GTPase activity

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.