Protein

MCA_02075_1

Length
393 amino acids

Gene name: TPK2

Description: putative cAMP-dependent protein kinase

Browser: contigB:166007-167189-

RNA-seq: read pairs 4351, FPKM 136.4, percentile rank 83.7% (100% = highest expression)

Protein function

Annotation:TPK2putative cAMP-dependent protein kinase
KEGG:K04345PKA protein kinase A [EC:2.7.11.11]
EGGNOG:0PHM9PKA1camp-dependent protein kinase
SGD closest match:S000006124TPK2cAMP-dependent protein kinase type 2
CGD closest match:CAL0000181882TPK2cAMP-dependent protein kinase catalytic subunit

Protein alignments

%idAln lengthE-value
MIA_05546_193.58%3270.0MIA_05546_1
A0A060T576_BLAAD92.05%3270.0ARAD1B02112p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02112g PE=3 SV=1
A0A167FQA5_9ASCO91.44%3270.0cAMP-dependent protein kinase catalytic subunit TPK2 OS=Sugiyamaella lignohabitans GN=TPK2 PE=4 SV=1
A0A1E3PTB6_9ASCO91.13%3270.0Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45095 PE=3 SV=1
Q6CCL9_YARLI90.83%3270.0YALI0C08305p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C08305g PE=3 SV=1
A0A0J9XFE6_GEOCN89.51%3240.0Similar to Saccharomyces cerevisiae YPL203W TPK2 cAMP-dependent protein kinase catalytic subunit OS=Geotrichum candidum GN=BN980_GECA13s01330g PE=3 SV=1
A0A1D8PHU1_CANAL82.26%3270.0cAMP-dependent protein kinase catalytic subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TPK2 PE=3 SV=1
UniRef50_A0A1D8PHU182.26%3270.0cAMP-dependent protein kinase catalytic subunit n=221 Tax=Fungi TaxID=4751 RepID=A0A1D8PHU1_CANAL
KAPB_YEAST82.87%3270.0cAMP-dependent protein kinase type 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPK2 PE=1 SV=2
A0A1E4TA68_9ASCO83.02%3180.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_124337 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0717

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 393

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. Domain IPR000961
    AGC-kinase, C-terminal
    1. SM00133 (pkinase_C_6)
    2. PS51285 (AGC_KINASE...)
  4. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  5. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. PIRSF000654 (ILK)
  4. cd05580 (STKc_PKA_like)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd05580
  3. polypeptide substr...
  4. regulatory subunit...
  5. activation loop (A...

Protein sequence

>MCA_02075_1
MSSNTVPSEKDSVPSSTDTATSATTINTTTTTTSAPLDASSIQQQSIPNQQTGAASSTPTQQASSSFPHRSTVSKGKYTL
SDFQILRTLGTGSFGRVHLVRSIHNNRYYAIKVLKKVQIVRMRQVEHTNDERRMLKLVEHPFLIRMWGTFQDSRNLFMVM
DYIEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHSHNIIYRDLKPENILLDKNGHIKITDFGFAKEVPDVTWTLCG
TPDYIAPEVVTTKAYNKSVDWWSLGILIYEMLTGYTPFYDQTPMKTYENILMGHVKYPSYLNPDAVDLLQRLITKDLSKR
LGNLLGGSQDVKNHPWFSEVIWEKLLSKDIETPYEPPIQSGVGDTSLFDRYPEEELDYGIVTPDPYADLFTDF

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.