Protein

MCA_01997_1

Length
286 amino acids

Browser: contigB:10604-11575-

RNA-seq: read pairs 5723, FPKM 246.4, percentile rank 90.3% (100% = highest expression)

Protein function

KEGG:K02725PSMA1 20S proteasome subunit alpha 6 [EC:3.4.25.1]
EGGNOG:0PHF0FG05222.1The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
SGD closest match:S000004931PRE5Proteasome subunit alpha type-6
CGD closest match:CAL0000174387PRE5Proteasome endopeptidase complex

Protein alignments

%idAln lengthE-value
MIA_05583_180.44%2716e-160MIA_05583_1
A0A0J9X827_GEOCN75.87%2869e-157Proteasome endopeptidase complex OS=Geotrichum candidum GN=BN980_GECA04s07314g PE=3 SV=1
A0A060TCY6_BLAAD76.95%2561e-146Proteasome endopeptidase complex OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B19580g PE=3 SV=1
Q6CBM3_YARLI75.68%2596e-146Proteasome endopeptidase complex OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C17325g PE=3 SV=2
A0A1E3PT42_9ASCO73.55%2422e-137Proteasome endopeptidase complex OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45104 PE=3 SV=1
A0A1E4TEM6_9ASCO64.42%2675e-125Proteasome endopeptidase complex OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43836 PE=3 SV=1
A0A1D8PRH6_CANAL70.00%2403e-122Proteasome endopeptidase complex OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRE5 PE=3 SV=1
UniRef50_O1425062.55%2353e-109Probable proteasome subunit alpha type-6 n=397 Tax=Eukaryota TaxID=2759 RepID=PSA6_SCHPO
PSA6_YEAST60.26%2349e-97Proteasome subunit alpha type-6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRE5 PE=1 SV=1
A0A161HGK5_9ASCO74.40%1684e-90Proteasome endopeptidase complex OS=Sugiyamaella lignohabitans GN=PRE5 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0340

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 286

Detailed signature matches

  1. Family IPR001353
    Proteasome, subunit alpha/beta
    1. PF00227 (Proteasome)
  2. Family IPR023332
    Proteasome alpha-type subunit
    1. PS51475 (PROTEASOME...)
  3. Family IPR035144
    Proteasome subunit alpha 1
    1. cd03749 (proteasome...)
  4. Domain IPR029055
    Nucleophile aminohydrolases, N-terminal
    1. G3DSA:3.60.20.10
    2. SSF56235 (N-termina...)
  5. Domain IPR000426
    Proteasome alpha-subunit, N-terminal domain
    1. PS00388 (PROTEASOME...)
    2. PF10584 (Proteasome...)
    3. SM00948 (Proteasome...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Residue annotation

  1. alpha subunit inte...
  2. active site cd03749

Protein sequence

>MCA_01997_1
MITIAHLFHFRNSYDNDAVTYSPTGRLYQVEYALEAVKQGSASVGLVSSTHAVLVALKRNTEDLGSYQKKIIGIDSHIGV
ALAGLAPDARILSNFLRQRAMSSKLVFGRPLPISKAVYAIADKAQSNTQQYGRRPYGVGLIIIGHDSKGPHLYEFLPSGS
VLEYFGTAIGARSQAARTYLERNFQEFPNATLEELIIHGLNALRDTLAQDKELTPKNTNIAFLGKDTPFKILEDDAVTPW
LEKLDSVSRTSHPLSSNQQENDDEPTNEEGDGNTEGQNATTMDTTE

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex