Protein

MCA_01982_1

Length
159 amino acids

Gene name: ATG12

Description: Ubiquitin-like protein ATG12

Browser: contigA:6025600-6026080-

RNA-seq: read pairs 731, FPKM 56.5, percentile rank 68.0% (100% = highest expression)

Protein function

Annotation:ATG12Ubiquitin-like protein ATG12
KEGG:K08336ATG12 ubiquitin-like protein ATG12
EGGNOG:0PRABATG12Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through an ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes
SGD closest match:S000000421ATG12Ubiquitin-like protein ATG12
CGD closest match:CAL0000188918ATG12Ubiquitin-like protein ATG12

Protein alignments

%idAln lengthE-value
MIA_05678_151.77%1411e-45MIA_05678_1
A0A0J9X4W1_GEOCN54.37%1033e-37Ubiquitin-like protein ATG12 OS=Geotrichum candidum GN=BN980_GECA03s02540g PE=3 SV=1
UniRef50_Q2UMW634.62%1561e-26Ubiquitin-like protein ATG12 n=17 Tax=leotiomyceta TaxID=716546 RepID=ATG12_ASPOR
ATG12_YARLI47.58%1248e-29Ubiquitin-like protein ATG12 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG12 PE=3 SV=1
A0A1E3PLF2_9ASCO36.96%927e-19Ubiquitin-like protein ATG12 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_11512 PE=3 SV=1
ATG12_YEAST36.96%925e-17Ubiquitin-like protein ATG12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG12 PE=1 SV=1
ATG12_CANAL40.23%871e-14Ubiquitin-like protein ATG12 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG12 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2108

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 159

Detailed signature matches

  1. Family IPR007242
    Ubiquitin-like protein Atg12
    1. PF04110 (APG12)
    2. cd01612 (APG12_C)
  2. Domain IPR029071
    Ubiquitin-related domain
    1. SSF54236 (Ubiquitin...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.10.20.90

Protein sequence

>MCA_01982_1
MSSSNDNTLNVADSTDRNILIPDDENNAVNYRLQNSQYVLSSMTATALLPKNNKPYLLDEIIEQTQSEINSSKVILKLKP
IGATPLLRQNIYRISGNQKFGTLVKYIRKQLKCSPSQQIFCYINNSFAPPLDEPIINLYNNFQIEGNLMISYCFTVAFG

GO term prediction

Biological Process

GO:0000045 autophagosome assembly

Molecular Function

None predicted.

Cellular Component

GO:0005737 cytoplasm