Protein

MCA_01895_1

Length
573 amino acids

Gene name: MET3

Description: Sulfate adenylyltransferase

Browser: contigA:5806725-5808447+

RNA-seq: read pairs 32777, FPKM 705.6, percentile rank 95.5% (100% = highest expression)

Protein function

Annotation:MET3Sulfate adenylyltransferase
KEGG:K00958sat sulfate adenylyltransferase [EC:2.7.7.4]
EGGNOG:0PFXEMET3Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids (By similarity)
SGD closest match:S000003771MET3Sulfate adenylyltransferase
CGD closest match:CAL0000178072MET3Sulfate adenylyltransferase

Protein alignments

%idAln lengthE-value
MIA_02605_191.45%5730.0MIA_02605_1
A0A0J9X4N8_GEOCN87.09%5730.0Sulfate adenylyltransferase OS=Geotrichum candidum GN=MET3 PE=3 SV=1
A0A1E3PPW2_9ASCO82.90%5730.0Sulfate adenylyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=MET3 PE=3 SV=1
A0A060T6D9_BLAAD83.60%5730.0Sulfate adenylyltransferase OS=Blastobotrys adeninivorans GN=MET3 PE=3 SV=1
A0A167FDH6_9ASCO84.29%5730.0Sulfate adenylyltransferase OS=Sugiyamaella lignohabitans GN=MET3 PE=3 SV=1
MET3_YARLI80.28%5730.0Sulfate adenylyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MET3 PE=3 SV=1
UniRef50_Q6CFD280.28%5730.0Sulfate adenylyltransferase n=788 Tax=root TaxID=1 RepID=MET3_YARLI
A0A1E4T9R9_9ASCO71.50%5720.0Sulfate adenylyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=MET3 PE=3 SV=1
MET3_YEAST66.82%4250.0Sulfate adenylyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET3 PE=1 SV=2
MET3_CANAL57.79%4880.0Sulfate adenylyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET3 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1782

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 573

Detailed signature matches

  1. Family IPR027535
    Sulfate adenylyltransferase
    1. MF_03106 (Sulf_aden...)
  2. Family IPR002891
    Adenylyl-sulfate kinase
    1. cd02027 (APSK)
    2. TIGR00455
  3. Domain IPR015947
    PUA-like domain
    1. SSF88697 (PUA domai...)
  4. Domain IPR025980
    ATP-sulfurylase PUA-like domain
    1. PF14306 (PUA_2)
  5. Domain IPR002650
    Sulphate adenylyltransferase
    1. cd00517 (ATPS)
    2. TIGR00339
  6. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  7. Domain IPR024951
    Sulphate adenylyltransferase catalytic domain
    1. PF01747 (ATP-sulfur...)
  8. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.10.40...
  2. G3DSA:3.40.50...
  3. PF01583 (APS_kinase)
  4. SSF52374 (Nucleotid...)

Residue annotation

  1. active site cd00517
  2. HXXH motif cd00517
  3. flexible loop cd00...
  4. ligand-binding sit...

Protein sequence

>MCA_01895_1
MSNPPHGGVLKDLLARDAPIRDKLAAESETLKDIVLTERQLCDLELIISGGFSPLEGFLNEKDYNGVVENLRLADGTLFP
IPITLDVSKEEIDAAGIKPGARITLRDFRDDVALAILTVEDVYKPDKENEAKKVFRGDPEHPANRYLFNIAKEYYVGGKL
QAINRLNHYDYVGLRNTPAELRSQFSKLGWSKVVAFQTRNPMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTR
VRVYQAILPRYPNGLAYLSLLPLAMRMAGDREAVWHAIIRKNHGVTHFIVGRDHAGPGKNSKGEEFYGPYDAQKLVEKYR
DELGIEVVPFQQMTYLPDQDEYAPKDEVPEGVQTLDISGTELRKRLKLGLPIPEWFSYPEVVKVLRESHPPRVKQGFTIF
LTGYYNSGKDSIGRALQVSLNQQGGRSVSLLLGETVRAELSKELGFTKEDRHTNIQRIAFVASELTRSGAAVIAAPIAPF
EESRQYAREIVEKAGGNFFLVHVATPLDHSEKTDRRGVYKRARNGEIKNFTGVDDPYEVPKNPDVVVDLTKIDVRTAVHQ
ITLHLESQGFFGN

GO term prediction

Biological Process

GO:0000096 sulfur amino acid metabolic process
GO:0000103 sulfate assimilation

Molecular Function

GO:0004020 adenylylsulfate kinase activity
GO:0004781 sulfate adenylyltransferase (ATP) activity
GO:0005524 ATP binding

Cellular Component

None predicted.