MCA_01810_1

Protein

Length

1,612 amino acids

RNA-seq: read pairs 3125, FPKM 23.9, percentile rank 46.4% (100% = highest expression)

Protein function

KEGG:	K11718	HUGT	UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]
EGGNOG:	0PHC3	FG07940.1	UDP-glucose glycoprotein glucosyltransferase
SGD closest match:	S000005863	KRE5	Killer toxin-resistance protein 5
CGD closest match:	CAL0000179466	KRE5	Kre5p

Protein alignments

	%id	Aln length	E-value
MIA_02352_1	51.48%	1620	0.0	MIA_02352_1
A0A0J9XG24_GEOCN	41.51%	1655	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA12s03376g PE=4 SV=1
UniRef50_A0A0J9XG24	41.51%	1655	0.0	Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XG24_GEOCN
A0A060TAK0_BLAAD	38.12%	1603	0.0	ARAD1D20196p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20196g PE=4 SV=1
A0A1E3PFF7_9ASCO	38.44%	1605	0.0	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28763 PE=4 SV=1
A0A167DST0_9ASCO	59.05%	503	0.0	Kre5p OS=Sugiyamaella lignohabitans GN=KRE5 PE=4 SV=1
Q6CC41_YARLI	48.11%	607	3e-166	YALI0C12661p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12661g PE=4 SV=1
A0A1E4THD5_9ASCO	76.01%	271	3e-133	Glycosyltransferase family 24 protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17832 PE=4 SV=1
A0A1D8PJN6_CANAL	54.07%	344	4e-104	Kre5p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KRE5 PE=4 SV=1
KRE5_YEAST	32.26%	217	4e-19	Killer toxin-resistance protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KRE5 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1371

Protein family membership

UDP-glucose:Glycoprotein Glucosyltransferase (IPR009448)

Domains and repeats

Domain
1,291 - 1,573
Nucleotide-diphospho-sugar transferases (IPR029044)

1 200 400 600 800 1000 1200 1400 1612

Detailed signature matches

IPR009448

UDP-glucose:Glycoprotein Glucosyltransferase
1. PF06427 (UDP-g_GGTase)
  
  30 - 1,215
  
  Pfam
  PF06427 (UDP-g_GGTase)
IPR029044

Nucleotide-diphospho-sugar transferases
1. G3DSA:3.90.55...
  
  1,291 - 1,573
  
  GENE3D
  G3DSA:3.90.550.10 (G3DSA:3.90.550.10)
2. SSF53448 (Nucleotid...)
  
  1,291 - 1,562
  
  SUPERFAMILY
  SSF53448 (Nucleotide-diphospho-sugar transferases)

no IPR

Unintegrated signatures

Coil

1,582 - 1,602

COILS
Coil (Coil)
NON_CYTOPLASM... (N...)

21 - 1,612

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 20

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

16 - 20

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

4 - 15

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 3

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
SignalP-noTM

1 - 20

SignalP euk
SignalP-noTM (SignalP-noTM)
cd06432 (GT8_HUGT1_...)

1,291 - 1,538

CDD
cd06432 (GT8_HUGT1_C_like)
mobidb-lite (disord...)

1,582 - 1,612

MobiDB Lite
mobidb-lite (disorder_prediction)

405 - 433

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative ligand bi...

1,296V

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,297A

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,298S

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,301L

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,302Y

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,375I

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,391F

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,393D

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,394A

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,395D

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,420M

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,449I

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,450S

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,451A

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,487D

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,488Q

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,511E

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,512T

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,526D

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,528C

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,529N

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)

1,534K

putative ligand binding site
1,296V, 1,297A, 1,298S, 1,301L, 1,302Y, 1,375I, 1,391F, 1,393D, 1,394A, 1,395D, 1,420M, 1,449I, 1,450S, 1,451A, 1,487D, 1,488Q, 1,511E, 1,512T, 1,526D, 1,528C, 1,529N, 1,534K
CDD
cd06432 (GT8_HUGT1_C_like)
metal binding site...

1,393D

metal binding site
1,393D, 1,395D, 1,526D
CDD
cd06432 (GT8_HUGT1_C_like)

1,395D

metal binding site
1,393D, 1,395D, 1,526D
CDD
cd06432 (GT8_HUGT1_C_like)

1,526D

metal binding site
1,393D, 1,395D, 1,526D
CDD
cd06432 (GT8_HUGT1_C_like)

Protein sequence

>MCA_01810_1
MRGFFGPLIIAASAICFVHGADTAINKDIKDIQIDLKANWQAVPYPLEVVEAIAAENSSAFYPLLTKLSTDESLRSNSSD
IKYYETAINFSIENNYITKDQIDFISLSLALHKHSAKIQALYQYHDTVALTPTTKECPVWLQYDKKSSCDSDTVFALETK
KGINSNENDLILPFDRVHGTNSNAQIVILYADITNPKFAVFHQHLLASASNGKIRYILRYRKPVGFSSDTSQQPLAGFGV
ELYIKRTDYLVIDDRDIKGAESTEELSSSEVKESFQLKAATEGATIKKNRINALGYRMANYIMSSEDKFGALVNSSLNFP
KYSYSISELPPHSKMKTELEQSALRPGNSLYINGAIVSPLKDDIFSITDLLDKERQMLNAFKELGISPEKAISFLTNDLA
DKDNKLGREKKANENDTDSDEESEAEEEEGKEDTGYDFEFIRYDYRSPGLIWLNDLANDQRYMSWSSSLNLYKTPTYALY
PAPVSKNIHTVVFIFNPNNKNHLQSMAEIFYLLERNVPAQVAIVPVTSSKNSEEIARELYAIYHSGHANNKMAVLRYIGN
VLSGVDHKVVFKALTGLEDSSHVPKELDISNYLKEANEMAKRLDINALEENVPPTVIVNGVIVSSENSWLRNVFDIIKTD
VQYVRKLLFNGQLNDAALEKAEVKDIILESAEKTRKSIISPSDKSSLVYSNMQEIYDSFWVTSSDSTSRVATFVHDRLPQ
NTENPALVSTIWIFGRAHTKEFLREVLEALKFLQNSKTATRINVVPFTPKTGLSKQQQTVAKKVSNILHFLSIKKAQHDV
SLEIVSTLFESLYGSLSPDEQRVTEMENMVRSSIDNPTKFFDHNFEYVSELKTPNFQNIKNHDVAIVLAGRVLTPKNQND
LLNEQDFQSLQSFEFQTRLRNIIAMAQKLQLEQIKNVEGDHPSFNFVDKLTSLVSKAKFSSSSKATGAESSKRSEIGTWE
LPHSSFEIGSSKQDSYLHIVAVIDPISERGQVYTSYLQTLSKIPHIWIKVILNPPMKLGSIPLNRFYRSCVPNAPSYDAA
GNLDNKSGVVTLSDMPQSTLMSMDLDVPSAWIAMPKISVHDLDNIILDKLARDEHSLTATYELKYILLEGHATDVTLQKA
PRGVALTLGSKVNPYITDTLVMENLGYFQLKAAPGLWHMDLKHGLSSKIFEIESNSDENGFVLENPKEIWITDLTGITVF
PKLKRNPGMRKANVLGEGTGFATPKGSRRALIDNSEDTGEDDPFEVFKFKAKNIWGDVTSRISNVIDSFQGNNEQKVMPM
APKEEKPPADINIFSVASGHLYERFLSIMTLSVTEHTNHTVKFWIIENFLSPKFKQFLPYLAKQRGFDYEFVTYKWPHWL
HHEQEKQRTIWGYKILFLDVLFPTSLNKIIFVDADQIVRTDMKELVDLDLHGAPYGFTPMCDSRKEIEGFRFWKQGYWKK
YLGKLKYHISALYVVDLVRFRELAAGDLLRQHYQMLSADAGSLANLDQDLPNHLQKSLPIYSLPQDWLWCETWCSDESLL
TAKTIDLCNNPMTKEPKLDRARRQVPEWTTYDNQVAEYNKNFESMLSEIEIRNVPDMVEDNMNDEEKEFSEAETVADEDE
DNEEFIREHDEL

GO term prediction

Biological Process

GO:0006486 protein glycosylation

Molecular Function

GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features