Protein

MCA_01795_1

Length
778 amino acids

Gene name: DBR1

Description: Lariat debranching enzyme

Browser: contigA:5477612-5479949+

RNA-seq: read pairs 1114, FPKM 17.7, percentile rank 38.0% (100% = highest expression)

Protein function

Annotation:DBR1Lariat debranching enzyme
KEGG:K18328DBR1 lariat debranching enzyme [EC:3.1.-.-]
EGGNOG:0PGPYPGUG_05494Lariat debranching enzyme
SGD closest match:S000001632DBR1Lariat debranching enzyme
CGD closest match:CAL0000191567DBR1RNA lariat debranching enzyme

Protein alignments

%idAln lengthE-value
A0A0J9X6B0_GEOCN35.22%7246e-113Similar to Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme OS=Geotrichum candidum GN=BN980_GECA04s02529g PE=4 SV=1
UniRef50_A0A0J9X6B035.22%7241e-109Similar to Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X6B0_GEOCN
MIA_02391_151.72%3194e-107MIA_02391_1
A0A167E851_9ASCO36.80%5192e-93Dbr1p OS=Sugiyamaella lignohabitans GN=DBR1 PE=4 SV=1
A0A060TCU5_BLAAD40.28%4278e-86ARAD1D38720p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38720g PE=4 SV=1
A0A1E3PMA9_9ASCO31.93%6647e-82Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46612 PE=4 SV=1
Q6C9G7_YARLI36.66%4611e-80YALI0D11352p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D11352g PE=4 SV=1
A0A1D8PPT8_CANAL47.42%2915e-79RNA lariat debranching enzyme OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DBR1 PE=4 SV=1
A0A1E4T9U9_9ASCO45.00%2602e-73Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_33026 PE=4 SV=1
DBR1_YEAST40.58%3083e-70Lariat debranching enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DBR1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0673

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 778

Detailed signature matches

  1. Domain IPR029052
    Metallo-dependent phosphatase-like
    1. SSF56300 (Metallo-d...)
    2. G3DSA:3.60.21.10
  2. Domain IPR004843
    Calcineurin-like phosphoesterase domain, ApaH type
    1. PF00149 (Metallophos)
  3. Domain IPR007708
    Lariat debranching enzyme, C-terminal
    1. SM01124 (DBR1_2)
    2. PF05011 (DBR1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. cd00844 (MPP_Dbr1_N)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd00844
  2. metal binding site...

Protein sequence

>MCA_01795_1
MAILNIFFEGCCHGSLNAIYDAILKANKSRCKIDLLLIGGDFQSLRTTADYNALSVPPKYRTLGDFSDYFTGKKKAPVLT
IFVGGNHEASNYLQELYYGGWVAPNIYYLGKTGSVIYKNKIRISGLSGIYNQHSYTKPNYEVIPYNNFYGNALRTVYHVR
NYDIAKLELFQKALKMAALENKNEKGTDQLVDIFVSHDWPEGIAHYGNLKKLLSNKPFFKADIAKNELGSPSNMRLLKSI
KPKYWLSAHLHVGFKAQVNHSEEFHKEKVKDANKTPVKPVIVKNDEEIYIDMDDLMDESNDKQHAQPVKNEDEIELDLDE
PEISTEATVTEHAEKKQEFEANLVNVQSKDEDGIKLDMKPTSDNQENKSSQVSTTDSIRDSEADTLSKNKDLSKKPSETS
PAITQFIALDKCLRNRKFFEHLEIPENEQLASLMNKLNPPSNSIPGSPDSEASSTSSLKRKRSKSPEYTNSDFSPLSYDP
EWLAVVKTMNDHFPIAKSKSNVEHKEDNKQDETNFQPDIDYQTGNWKFPELNLPLEESSANKIYVELEKNRKWVYSNLQG
KLAIPSWKYYFRDIRPSNYKNFENKRSTTEIEKSSLTPETKSFEELSNKQNSAEEYFTLAMTKADTVPIVNNPQTVYFCS
LLEIENMVETLANTITAQTPKEVLENANKNNNRPQNNNNNNHRNNNRQRNFQNTSRAGLNNNRGGRRNFQHFAPNNYQQD
HHQARNHDDKNPTESGHIDSSFEVNSKPGSSSSSSIMPNISAKPFDNNAPQYLSDSSD

GO term prediction

Biological Process

GO:0006397 mRNA processing

Molecular Function

GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

None predicted.