Protein
MCA_01767_1
Length
894 amino acids
Gene name: DEF1
Description: RNA polymerase II degradation factor 1
Browser: contigA:5409667-5412730-
RNA-seq: read pairs 9313, FPKM 128.6, percentile rank 82.8% (100% = highest expression)
Protein function
| Annotation: | DEF1 | RNA polymerase II degradation factor 1 | |
|---|---|---|---|
| EGGNOG: | 0PQNH | DEF1 | RNA polymerase II degradation factor recruits the ubiquitination machinery to the RNA polymerase II for polyubiquitination, removal and degradation, when RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation (By similarity) |
| CGD closest match: | CAL0000185361 | DEF1 | RNA polymerase II degradation factor 1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00708_1 | 40.71% | 253 | 5e-20 | MIA_00708_1 |
| A0A1E3PFF5_9ASCO | 55.56% | 45 | 3e-12 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_43929 PE=4 SV=1 |
| UniRef50_A0A1E3PFF5 | 55.56% | 45 | 7e-09 | Uncharacterized protein n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PFF5_9ASCO |
| A0A167EYP5_9ASCO | 53.33% | 45 | 5e-11 | RNAPII degradation factor (Predicted) OS=Sugiyamaella lignohabitans GN=AWJ20_2220 PE=4 SV=1 |
| Q6CCF1_YARLI | 58.14% | 43 | 2e-10 | YALI0C09933p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C09933g PE=4 SV=1 |
| A0A0J9X3M0_GEOCN | 63.16% | 38 | 5e-11 | Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s10746g PE=4 SV=1 |
| A0A060SX38_BLAAD | 48.89% | 45 | 8e-10 | ARAD1A01518p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A01518g PE=4 SV=1 |
| DEF1_CANAL | 50.00% | 42 | 2e-06 | RNA polymerase II degradation factor 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DEF1 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1331
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
894
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
cd14368 (CUE_DEF1_like)
-
mobidb-lite (disord...)
Protein sequence
>MCA_01767_1 MSTVPAQSDSKPPMIKSSTSSRQRRSQKTSGSHTEEQESEYSEELATLRELFPDWKNEDLIPLLSESDGNLEIVIEQIAQ GLAFKWGQVKKKSKDRPKKQDQSKKQDHSKKEFTDSSYPSQQKAHTNSSNSHPSLRNSIPRGPKANKTQSSAPPSTSTRN PKGIKRPQHSQPNGSSDDKQKSTDPSLPSTSSSHPPAATSTTPSSAPSWASLFADKSPPEPELPSKKTTTTNDDSSIPSI ASSDAHSDAITVKIPASESKPNQDDSVNTNNNIPAESTTTTTNTSTTTTSSLPTTTPAAPTTTTRSWAAVANSSAQKKPA PAAPVAQPPAVESVPASQEETTTTTQEPAVEQSTVEEQQAPEVSAEPETAETSAPAPEPSAEAEHEQEEQTSTQPPAVSS VSDAPTPSSVPPGLEKSEHTSSSITNNSISSPITSESNPIEVSQNQQNSNIPTGPASSTGPQSVATPTGPASERQQQQQQ QQQQQPIFLPTQPSHYNRRLNQDAPVILPGSLGNRSMGRLGAQFGSMNISNDESSQDKNSVDISSTPTQPRSEQQMQQSQ QQSQQHFSYQQPQQSYNSYNNSNNRFNQHSNNQFQQQSQQHQQPIQQQGHPQKPYNSYNNQNPYLFNGMPGYNNYNFHEY GYGGTNDIQRNNTANYFPHYQQHSQEGMTRGMGGFDQQGAPQQANRYASDKIAGAAAAAAATTNPSQSPATSSVSPGITS SSSGPAMPGYTQMMGGMPHYMGVSPYYMYPSYSYNPMQAYNNQKNYYGQQPFYEGSDYQVMQQQGGQQPPRQGGQQAGQQ GSQQAQGQQAGQQQSQEQSQGAGNAQSSLSGISDFLQREDKGAPGSPQSILGGTQISQSQLGGVPQQQQQQQQHYYSYAG YGQYNQGPGRQNWN
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.