Protein
MCA_01726_1
Length
1,156 amino acids
Gene name: SEC12
Description: Guanine nucleotide-exchange factor SEC12
Browser: contigA:5295518-5299046+
RNA-seq: read pairs 3355, FPKM 35.8, percentile rank 57.6% (100% = highest expression)
Protein function
| Annotation: | SEC12 | Guanine nucleotide-exchange factor SEC12 | |
|---|---|---|---|
| EGGNOG: | 0PGJ0 | SEC12 | Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy |
| SGD closest match: | S000005309 | SEC12 | Guanine nucleotide-exchange factor SEC12 |
| CGD closest match: | CAL0000181490 | SEC12 | Sec12p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A1E3PHK5_9ASCO | 35.64% | 289 | 3e-30 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46725 PE=4 SV=1 |
| UniRef50_A0A1E3PHK5 | 35.64% | 289 | 7e-27 | Uncharacterized protein n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PHK5_9ASCO |
| A0A060TA45_BLAAD | 29.03% | 465 | 2e-29 | ARAD1C42306p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42306g PE=4 SV=1 |
| MIA_05923_1 | 36.62% | 213 | 3e-27 | MIA_05923_1 |
| A0A0J9X2L7_GEOCN | 27.89% | 484 | 2e-25 | Similar to Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) OS=Geotrichum candidum GN=BN980_GECA01s03739g PE=4 SV=1 |
| A0A167F9I3_9ASCO | 27.60% | 471 | 7e-25 | Sar family guanine nucleotide exchange factor SEC12 OS=Sugiyamaella lignohabitans GN=SEC12 PE=4 SV=1 |
| SEC12_YEAST | 26.38% | 470 | 8e-16 | Guanine nucleotide-exchange factor SEC12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC12 PE=1 SV=1 |
| Q6CHH9_YARLI | 33.02% | 215 | 6e-12 | YALI0A08646p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A08646g PE=4 SV=1 |
| A0A1D8PPP9_CANAL | 26.23% | 305 | 8e-07 | Sec12p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SEC12 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0073
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
200
400
600
800
1000
1156
Detailed signature matches
-
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SSF50952 (Soluble q...)
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no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
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mobidb-lite (disord...)
Protein sequence
>MCA_01726_1 MSSFKQSSTVNVGYPVFAAKFLGDERLVIAGGGGEGKNGIKNKISVIDIDFEDTQPLRVATECILPDNEDSPTSLDVTNF GTIYAGINRDSKQVKSQSNDHLRVFQIATDPEKPIQEEIIGDVEIEERDESIIPACSASVFNTGVPGDYQKCTAVNLKTQ TLAISNALSGTTPPNTPVLAVLNTRELVNQMPILRFVSSPTDGSEINDVDISPNGELISYVTDKSLIIIPALPEEKPAIF KTQIQLNASDGSFDKLAPKGSALVKAKFFSDTQLIVAFNHPKRKGFTFAHFSISKAKNSNEFKLVPGRYKKIMSQSGVTS LDCVRWPDPATSDNQQATSLNLNEKTKNKTDTAQNLKQQPASSSGSTMGYVAFATADFSVGVCSLDTLKPLWVQKKAHNF AVTSVSLSRPCPKFVASSSAANTVTVAALPDPTKNLYKKNRPMTVVYSLASIIIIAVTAVLLQLAIQHQVLGDIASFKSL NKFQQSSSSVSSIISTETQPTIEISSSSSSSSYEPSSVSSVTESVVVEETVSVSTEIETETVVEEKSIEPPVVEKIVEEP VEEKATVEETIAEQPVAETPQENIQESSEPPIVERAAENIQPKEEDVKIEESAKPAESSESVDRDIFDTVTDSVGSVIKS VAGEPVDMEVNNKNSKESKESDIFDSVTDSIASIVKSVAGETDDAASSEEVAKKDASAETVNTIDSVVESADTPIASSVV DEVKSAASSVVGESSSTSTVEETVASSSSPEAVVESVAEKVEEQPEEEYDTMAIVDGPEFSQPPPHVTNEEKVNPVSQIV EEVKPSSSSTEEEVKYEPVETSKHDKDTKKDADNAHIEIIDNVIVGDSIPAEKEKVKETVAQEAEPEFEPVETSKFDKDA KKKDGTVGIEIVDEVIVGDQLPGDDEKKSQQTPDASEKIIAKQVQDDDETAEFEPVESAPLDENLVKDAENVRIEIVNEV IADEVRQENAAQQEEKKEKVVATENEKASDVKSSVASVESNVESTVQSETANIKSSIASAGSVVESSIAKAATAVTQVVN VDAAANAAQSVKSYVESVVGGSSSSSSSSSSSSPSSSSSATVEPSKEKAVVDEKVPNAGDLFDAGGDIDLGIPEESVVLV GDKQVVYSSTDGATVDVNGNEIKKSVKSATASHEDL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
Cellular Component
None predicted.