Protein

MCA_01695_1

Length
1,054 amino acids

Browser: contigA:5206377-5209542-

RNA-seq: read pairs 5461, FPKM 64.0, percentile rank 70.6% (100% = highest expression)

Protein function

KEGG:K01873VARS valyl-tRNA synthetase [EC:6.1.1.9]
EGGNOG:0PI3FFG06850.1Valyl-trna synthetase
SGD closest match:S000003326VAS1Valine--tRNA ligase, mitochondrial
CGD closest match:CAL0000181624VAS1Valine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_02399_188.50%9830.0MIA_02399_1
A0A0J9X8G0_GEOCN78.76%9840.0Similar to Saccharomyces cerevisiae YGR094W VAS1 Mitochondrial and cytoplasmic valyl-tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA05s01759g PE=3 SV=1
A0A060TC23_BLAAD74.57%9830.0ARAD1D38962p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38962g PE=3 SV=1
A0A167EK94_9ASCO75.43%9850.0Valine--tRNA ligase OS=Sugiyamaella lignohabitans GN=VAS1 PE=3 SV=1
A0A1E3PJB7_9ASCO72.66%9840.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83077 PE=3 SV=1
Q6C109_YARLI73.47%9800.0YALI0F20218p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20218g PE=3 SV=1
A0A1E4TM71_9ASCO69.30%9870.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1342 PE=3 SV=1
UniRef50_A0A1X7QYT769.07%9830.0Similar to Saccharomyces cerevisiae YGR094W VAS1 Mitochondrial and cytoplasmic valyl-tRNA synthetase n=3 Tax=Opisthokonta TaxID=33154 RepID=A0A1X7QYT7_9SACH
SYV_YEAST68.36%9830.0Valine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VAS1 PE=1 SV=2
A0A1D8PHR0_CANAL65.96%9900.0Valine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VAS1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0125

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1000 1054

Detailed signature matches

  1. Family IPR002303
    Valine-tRNA ligase
    1. PR00986 (TRNASYNTHVAL)
    2. TIGR00422
    3. MF_02004 (Val_tRNA_...)
  2. Domain IPR002300
    Aminoacyl-tRNA synthetase, class Ia
    1. PF00133 (tRNA-synt_1)
  3. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  4. Domain IPR009008
    Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
    1. SSF50677 (ValRS/Ile...)
  5. Domain IPR009080
    Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    1. G3DSA:1.10.73...
    2. SSF47323 (Anticodon...)
  6. Domain IPR013155
    Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
    1. PF08264 (Anticodon_1)
  7. Domain IPR033705
    Valyl tRNA synthetase, anticodon-binding domain
    1. cd07962 (Anticodon_...)
  8. Domain IPR019499
    Valyl-tRNA synthetase, tRNA-binding arm
    1. G3DSA:1.10.28...
  9. SITE IPR001412
    Aminoacyl-tRNA synthetase, class I, conserved site
    1. PS00178 (AA_TRNA_LI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SSF52374 (Nucleotid...)
  3. cd00817 (ValRS_core)
  4. mobidb-lite (disord...)

Residue annotation

  1. active site cd00817
  2. HIGH motif cd00817
  3. KMSKS motif cd00817
  4. tRNA binding surfa...
  5. anticodon binding ...

Protein sequence

>MCA_01695_1
MSEKEQQAAASTPTDGAPKKIKTEKELEKERKKAEKLAKFEAKQAAKKAAPQKSEKAAKKAEKKPAEPIPEFVDKTVPGE
KKILLSLDDPALKAYNPKAVESSWDLWWDKKGFFKPALTESGDIKPEGKFVIPAPPPNVTGALHIGHGLTIAIQDTLIRF
NRMKGKSTLFIPGFDHAGISTQSVVEKMLWKNEKKTRHDLGREKFTELVWEWKEDYHQRIKRQLHSLGSSYDWSREAFTL
DEPRSKAVVEAFVRLHDDGTIYRASRLVNWCVALNTTLSNLEVENKEVTGRTLLKVPGYDEPVEFGVITSFAYPIEDSDE
KIIVATTRPETMFGDSGIAVHPDDPRYKHLHGKFAIHPFLGRKIPIVTDSEAVDMEFGTGAVKITPAHDPNDYATGKRHN
LEMINILNDDGTFNENAGSYAGMKRFDARKKVIEDLKEKGLLIGSEDNPMTIPFCAKSNDVIEPLLKPQWWVAQKPQAEA
AIKAVRDGKITIFPKTSENEFFQWLEHIQDWCISRQLWWGHRCPVYFVKLEDSSVEQDPADNKWWIAGRTLEEAEEKAAK
KFAGQKYTLEQDEDVLDTWFSSGLWPFSTLGWPENTDDMKKFYPMSLLETGWDILFFWVARMIMLGIKLTGEVPFTEVFC
HSLVRDAQGRKMSKSLGNVIDPLDVIYGTSLQELHDKLKSGNLDPREIAKAEQGQKMSFPNGIPECGTDALRFALCAYTT
GGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPAKLEPSGKESLVEKWILHKYTTAAQTIAKALDERDFLTST
TAVYSYWLYELCDVYIENSKYLFIEGTPEQKKSAQDTLYIALEGALRLIHPFMPFITEELWQRLPRRADDPESISITSYP
EFNEKAYNPTAETEYALVLDIVKGARSILAQYNILKNATILVQASNAETAKIVSEQEGFILSLVKAASKMELMKADDKVP
SGSVVSVISPEVSVYAIVKGHVDFDAEIKKAQDKIAKIEKSKASLEKQISVKDYETKVREEVREANVKRLEGYAAEISGL
EAVVETFQKLKLDN

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006438 valyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004832 valine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm