MCA_01694_1

Protein

Length

230 amino acids

Gene name: RRP46

Description: Exosome complex component RRP46

Browser: contigA:5205300-5206150+

RNA-seq: read pairs 228, FPKM 12.2, percentile rank 29.5% (100% = highest expression)

Protein function

Annotation:		RRP46	Exosome complex component RRP46
KEGG:	K12590	RRP46	exosome complex component RRP46
EGGNOG:	0PMYB	RRP46	Exosome complex
SGD closest match:	S000003327	RRP46	Exosome complex component RRP46
CGD closest match:	CAL0000179859	orf19.81	Exosome non-catalytic core subunit

Protein alignments

	%id	Aln length	E-value
A0A0J9X8C7_GEOCN	56.95%	223	3e-87	Similar to Saccharomyces cerevisiae YGR095C RRP46 Exosome non-catalytic core component OS=Geotrichum candidum GN=BN980_GECA05s02573g PE=4 SV=1
MIA_02398_1	58.30%	223	5e-86	MIA_02398_1
A0A167EK80_9ASCO	49.33%	223	3e-75	Rrp46p OS=Sugiyamaella lignohabitans GN=RRP46 PE=4 SV=1
UniRef50_A0A167EK80	49.33%	223	7e-72	Rrp46p n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A167EK80_9ASCO
A0A060THK0_BLAAD	48.44%	225	2e-69	ARAD1D38984p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38984g PE=4 SV=1
A0A1E3PGY4_9ASCO	49.33%	225	1e-67	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83583 PE=4 SV=1
Q6C108_YARLI	42.25%	213	4e-57	YALI0F20240p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20240g PE=4 SV=1
RRP46_YEAST	36.99%	219	1e-45	Exosome complex component RRP46 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP46 PE=1 SV=2
A0A1D8PHQ0_CANAL	30.80%	224	5e-29	Exosome non-catalytic core subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.81 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1680
Predicted cleavage: 17

Protein family membership

None predicted.

Domains and repeats

Domain
5 - 226
PNPase/RNase PH domain (IPR027408)
Domain
8 - 128
Ribosomal protein S5 domain 2-type fold (IPR020568)
Exoribonuclease, phosphorolytic domain 1 (IPR001247)
Domain
128 - 224
Exoribonuclease, phosphorolytic domain 2 (IPR015847)

1 50 100 150 200 230

Detailed signature matches

IPR027408

PNPase/RNase PH domain
1. G3DSA:3.30.23...
  
  5 - 226
  
  GENE3D
  G3DSA:3.30.230.70 (G3DSA:3.30.230.70)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  8 - 127
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR001247

Exoribonuclease, phosphorolytic domain 1
1. PF01138 (RNase_PH)
  
  8 - 128
  
  Pfam
  PF01138 (RNase_PH)
IPR015847

Exoribonuclease, phosphorolytic domain 2
1. PF03725 (RNase_PH_C)
  
  132 - 205
  
  Pfam
  PF03725 (RNase_PH_C)
2. SSF55666 (Ribonucle...)
  
  128 - 224
  
  SUPERFAMILY
  SSF55666 (Ribonuclease PH domain 2-like)

no IPR

Unintegrated signatures

cd11372 (RNase_PH_R...)

7 - 212

CDD
cd11372 (RNase_PH_RRP46)

Residue annotation

Rrp40 interface cd...

11S

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

13L

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

14Q

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

16V

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

17D

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

36P

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

37I

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

38E

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

86H

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

88R

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

126S

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

128P

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

129V

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

130L

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

132V

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)

175K

Rrp40 interface
11S, 13L, 14Q, 16V, 17D, 36P, 37I, 38E, 86H, 88R, 126S, 128P, 129V, 130L, 132V, 175K
CDD
cd11372 (RNase_PH_RRP46)
hexamer interface ...

15R

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

17D

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

32S

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

34T

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

35G

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

36P

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

52E

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

54V

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

59V

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

68L

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

71E

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

75T

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

89S

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

94V

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

99E

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

123I

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

124D

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

125A

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

182L

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

183L

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

184L

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

185C

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

186E

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

187S

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

188S

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

189G

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

190S

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

191F

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

192T

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

193K

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

196L

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

200L

hexamer interface
15R, 17D, 32S, 34T, 35G, 36P, 52E, 54V, 59V, 68L, 71E, 75T, 89S, 94V, 99E, 123I, 124D, 125A, 182L, 183L, 184L, 185C, 186E, 187S, 188S, 189G, 190S, 191F, 192T, 193K, 196L, 200L
CDD
cd11372 (RNase_PH_RRP46)

Protein sequence

>MCA_01694_1
MSTLVPQIQTSLLQRVDGSASWDYNDTKVVVSVTGPIEAKSRDEIPTAATVELVVRPAVGLSSTRDHLLAEKIQTTFSSV
ILKHLHPRSLIQIVVQILEAGESLKYNVLELASAINSTSIALIDASIPVLGVVSAVAVAITEPSDDSEDPIFKIDPSGEE
LNEATSWHIIAYEIKQGEITRLLLCESSGSFTKPQLFKALELAAEGCLKVYQHFETAIEKKLENDFYWAK

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_01694_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component