Protein
MCA_01644_1
Length
486 amino acids
Gene name: EHD3C
Description: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Browser: contigA:5060811-5062336-
RNA-seq: read pairs 7398, FPKM 187.7, percentile rank 87.3% (100% = highest expression)
Protein function
| Annotation: | EHD3C | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial | |
|---|---|---|---|
| KEGG: | K05605 | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] |
| EGGNOG: | 0PFPY | FG07019.1 | 3-hydroxyisobutyryl-CoA hydrolase |
| SGD closest match: | S000002443 | EHD3 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
| CGD closest match: | CAL0000174772 | EHD3 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9X434_GEOCN | 62.09% | 488 | 0.0 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Geotrichum candidum GN=BN980_GECA02s02331g PE=3 SV=1 |
| MIA_02490_1 | 61.97% | 476 | 0.0 | MIA_02490_1 |
| A0A1E3PJK4_9ASCO | 52.35% | 489 | 4e-174 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46814 PE=3 SV=1 |
| UniRef50_A0A1E3PJK4 | 52.35% | 489 | 1e-170 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PJK4_9ASCO |
| A0A060SXR4_BLAAD | 50.94% | 481 | 1e-169 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A11396g PE=3 SV=1 |
| A0A167EH75_9ASCO | 50.31% | 479 | 9e-164 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Sugiyamaella lignohabitans GN=EHD3 PE=3 SV=1 |
| A0A1E4TAJ0_9ASCO | 51.09% | 458 | 5e-143 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3410 PE=3 SV=1 |
| Q6CA37_YARLI | 44.06% | 488 | 5e-137 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06215g PE=3 SV=1 |
| Q5AI24_CANAL | 40.43% | 507 | 2e-111 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=EHD3 PE=3 SV=1 |
| HIBCH_YEAST | 36.85% | 464 | 4e-81 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EHD3 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9842
Predicted cleavage: 34
Protein family membership
- Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type (IPR032259)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
400
450
486
Detailed signature matches
no IPR
Unintegrated signatures
-
-
cd06558 (crotonase-...)
Residue annotation
-
substrate binding ...
-
oxyanion hole (OAH...
-
trimer interface c...
Protein sequence
>MCA_01644_1 MLSNRLSILRSLQNMPLKARINPAMLPKLTRNYSSASSQEDDVLFYPNKAVRFIQLNRPSKLNALNQSMVDKITPRLIEW SKSDSAQTIILKATGNRALCAGGDITSLAVGIKEKQDEGSAAAAAFFRDEYQLNHLIASYSKPYISIMNGITMGGGVGLS VHAPFRIATENTVFAMPETDIGFFPDVGGTFFLPRLDGQVGAYLALTSQRLKGYDVVSAGIATHYVPESLLPELEARLSE IFDEKDIESVDIFSLVNDAIEDFATDAPEGYKYFLSGADREAIDAAFSQPTVEDVIRFLETSDASIAQDTIKKINQRSPT SIKVTFEALKRGKTLDITSALTAEYRLAERFMYGTEFAEGVTAKLIRREPPKWNPPELAAVTPSIVNEYLTPIPDSKNPD IDFIDPSVNFFEYPHKFGLPTEKEVRDYITGDDSSDREFKVNKEEVLTYFDSKTKSKLGVRRKIEEILARKTKPDSRDPT LLDWVE
GO term prediction
Biological Process
GO:0008152 metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
Cellular Component
None predicted.