Protein

MCA_01637_1

Length
419 amino acids

Gene name: TRP1

Description: N-(5'-phosphoribosyl)anthranilate isomerase

Browser: contigA:5040947-5042207+

RNA-seq: read pairs 507, FPKM 14.9, percentile rank 33.9% (100% = highest expression)

Protein function

Annotation:TRP1N-(5'-phosphoribosyl)anthranilate isomerase
KEGG:K13501TRP1 anthranilate synthase / indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC:4.1.3.27 4.1.1.48 5.3.1.24]
EGGNOG:0PNEUTRP1N-(5'-phosphoribosyl)anthranilate isomerase
SGD closest match:S000002414TRP1N-(5'-phosphoribosyl)anthranilate isomerase
CGD closest match:CAL0000186853TRP1N-(5'-phosphoribosyl)anthranilate isomerase

Protein alignments

%idAln lengthE-value
MIA_06278_146.35%3567e-80MIA_06278_1
A0A0J9XFT7_GEOCN40.64%3744e-70Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA12s01748g PE=3 SV=1
UniRef50_A0A0J9XFT740.64%3748e-67Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XFT7_GEOCN
Q1M2R6_BLAAD49.59%2422e-69ARAD1C20658p OS=Blastobotrys adeninivorans GN=atrp1 PE=3 SV=1
A0A1E3PNB9_9ASCO48.96%2415e-67Phosphoribosylanthranilate isomerase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_14930 PE=3 SV=1
F2Z5Z5_YARLI44.63%2428e-56YALI0B07667p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B07667g PE=3 SV=1
A0A167ET59_9ASCO52.33%1726e-48Phosphoribosylanthranilate isomerase TRP1 OS=Sugiyamaella lignohabitans GN=TRP1 PE=3 SV=1
A0A1E4TFJ6_9ASCO35.66%2441e-33Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_106605 PE=3 SV=1
TRPF_YEAST37.60%2582e-34N-(5'-phosphoribosyl)anthranilate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP1 PE=1 SV=2
TRPF_CANAL35.46%2518e-34N-(5'-phosphoribosyl)anthranilate isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TRP1 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0317

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 419

Detailed signature matches

  1. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  2. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)
  3. Domain IPR001240
    N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
    1. PF00697 (PRAI)
    2. cd00405 (PRAI)
    3. MF_00135 (PRAI)

Residue annotation

  1. active site cd00405

Protein sequence

>MCA_01637_1
MNCLTLLSNDKSKADSSGVKSLYSRISSASEIYPYAREGVSLFLVDKSALEQESLQHIRHVIDTLYYKPLLVYDLSDDEE
RNEELEALVDGICVASEGSPAVSDRFLSIVKVNSPSSSNTNVYNTVENTITIALPDGKEERIVISECKITPSFKEDSAFE
SGSLDSSSTKVLPIAKICGLKTAEAAQVAIDHGATMLGMIMVPGRSRTVGEAEGLAISQLVRQVREQRKQQEEDNNVQNL
AKAGDSHFYVNSLKSRKVKGQQHSPGPFLVGVFRNQPLSQVLELQKKYQLDYVQLHGDEPLSWCESIPVPVIKRFTPGTE
QFPECLKSGLHVISLIDSPLGGEGKLVDRSTLKKYAQLGARFVIAGGLTPDNVKEVYDNGCEELQGMIGVDVSGGVESSE
GVKDYGKIKRFLESIISSK

GO term prediction

Biological Process

GO:0006568 tryptophan metabolic process
GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004640 phosphoribosylanthranilate isomerase activity

Cellular Component

None predicted.