Protein

MCA_01586_1

Length
613 amino acids

Gene name: MDR1B

Description: Multidrug resistance protein 1

Browser: contigA:4900360-4902202+

RNA-seq: read pairs 5799, FPKM 116.7, percentile rank 81.3% (100% = highest expression)

Protein function

Annotation:MDR1BMultidrug resistance protein 1
KEGG:K08158MDR1 MFS transporter, DHA1 family, multidrug resistance protein
EGGNOG:0QDYJFG02865.1resistance protein
SGD closest match:S000000212FLR1Fluconazole resistance protein 1
CGD closest match:CAL0000173998MDR1Multidrug resistance protein 1

Protein alignments

%idAln lengthE-value
MIA_05930_159.67%6150.0MIA_05930_1
A0A0J9XL11_GEOCN52.43%6180.0Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily OS=Geotrichum candidum GN=BN980_GECA27s00021g PE=4 SV=1
UniRef50_A0A0J9X5S851.62%6160.0Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5S8_GEOCN
A0A1E3PJA3_9ASCO44.10%6192e-162SCR1 protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47140 PE=4 SV=1
A0A060T943_BLAAD42.51%6212e-153ARAD1D12672p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D12672g PE=4 SV=1
Q6CCP4_YARLI40.76%6061e-142YALI0C07722p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C07722g PE=4 SV=1
MDR1_CANAL46.07%4715e-132Multidrug resistance protein 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDR1 PE=1 SV=2
A0A167CAG3_9ASCO43.74%4715e-121Flr1p OS=Sugiyamaella lignohabitans GN=FLR1 PE=4 SV=1
FLR1_YEAST37.90%4674e-99Fluconazole resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLR1 PE=1 SV=1
A0A1E4TIX5_9ASCO34.19%4653e-73Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14557 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7755

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 613

Detailed signature matches

  1. Family IPR011701
    Major facilitator superfamily
    1. PF07690 (MFS_1)
  2. Domain IPR020846
    Major facilitator superfamily domain
    1. PS50850 (MFS)
    2. SSF103473 (MFS gene...)
    3. cd06174 (MFS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:1.20.12...
  3. NON_CYTOPLASM... (N...)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. mobidb-lite (disord...)

Residue annotation

  1. putative substrate...

Protein sequence

>MCA_01586_1
MASDLIRESFIGFFINKLSKGKILPYTEEKPGFVVPSIYLENPPLLSRKQSVASSMHNDQRTHQYTTEVNSPDSNQGSEK
DFPVNGEALNTLCPEKSCPSDDEEKALCQKPVAYTAENCGDQEKMIGLRPHKSEDPLAIPDDSRSIDHGQYIVVDWYGPD
DKDNPKNWSNWKKVWTIFSIAVLTVSIYMGSSIYTPGAAEMMVDLNTTRVKAVLPLTMFVMGYGMGPMVFSPLSEHPPFG
RTFIYIINLALFCILQVPTALAKNIETIIGLRFLAGLCASPALSTGGATIGDVLSKNMFVGLLAWAIASFCGPTFGPLIG
GVFSQLVTWRWTFWFLCCISGFALAVLSLLLPETNHATILHRRAARLRKLTGNMAIRSPFEVQEKQTVPELIKETLWRPV
VIIFEPIVICLNLYTAFIYIILNSWFESLPMVFNDFYKFNLIEGGVVYLAAIIGGLIGGGCYYYTYNRIDRSSNPNIEKY
LIPAKIGSFFLPVALFIFSWGTSTKTHWMAPVSSLTIFSIGGIFLFQSIFAYLSRGFPRFLASVFAGNCLVRSVSASVFP
LFTHAMYANLAREKFPVALAGTIWACIGIIMVPIPFVISHYGIRLRGRSKYAN

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane