Protein

MCA_01525_1

Length
669 amino acids

Browser: contigA:4728462-4731027-

RNA-seq: read pairs 25032, FPKM 461.6, percentile rank 94.0% (100% = highest expression)

Protein function

KEGG:K01895ACSS acetyl-CoA synthetase [EC:6.2.1.1]
EGGNOG:0PGXPACS1Acetate-CoA ligase
SGD closest match:S000004143ACS2Acetyl-coenzyme A synthetase 2
CGD closest match:CAL0000197968ACS2Acetyl-coenzyme A synthetase 2

Protein alignments

%idAln lengthE-value
MIA_03334_186.87%6550.0MIA_03334_1
A0A0J9XF58_GEOCN84.36%6650.0Acetyl-coenzyme A synthetase OS=Geotrichum candidum GN=BN980_GECA14s00384g PE=3 SV=1
A0A1E3PTR0_9ASCO75.66%6860.0Acetyl-coenzyme A synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_40027 PE=3 SV=1
A0A167BYL8_9ASCO76.56%6400.0Acetyl-coenzyme A synthetase OS=Sugiyamaella lignohabitans GN=ACS2 PE=3 SV=1
A0A060T8N5_BLAAD73.51%6530.0Acetyl-coenzyme A synthetase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D12826g PE=3 SV=1
A0A1E4TAC1_9ASCO71.36%6530.0Acetyl-coenzyme A synthetase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3299 PE=3 SV=1
UniRef50_G0RZW269.49%6620.0Acetyl-coenzyme A synthetase-like protein n=1 Tax=Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) TaxID=759272 RepID=G0RZW2_CHATD
ACS2_CANAL68.32%6660.0Acetyl-coenzyme A synthetase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ACS2 PE=3 SV=3
Q6C2Q5_YARLI70.94%6470.0Acetyl-coenzyme A synthetase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F05962g PE=3 SV=1
ACS2_YEAST64.84%6770.0Acetyl-coenzyme A synthetase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0513

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 669

Detailed signature matches

  1. Family IPR011904
    Acetate-CoA ligase
    1. cd05966 (ACS)
    2. TIGR02188
  2. Domain IPR032387
    Acetyl-coenzyme A synthetase, N-terminal domain
    1. PF16177 (ACAS_N)
  3. Domain IPR000873
    AMP-dependent synthetase/ligase
    1. PF00501 (AMP-binding)
  4. Domain IPR025110
    AMP-binding enzyme, C-terminal domain
    1. PF13193 (AMP-binding_C)
  5. SITE IPR020845
    AMP-binding, conserved site
    1. PS00455 (AMP_BINDING)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.30.38.10
  2. G3DSA:3.30.30...
  3. G3DSA:3.40.50...
  4. SSF56801 (Acetyl-Co...)

Residue annotation

  1. CoA binding site c...
  2. active site cd05966
  3. acyl-activating en...
  4. acetate binding si...
  5. AMP binding site c...

Protein sequence

>MCA_01525_1
MTQQQPKVVAEAANIKAIPTPKAFFDKHPSQPHLNDLEHYKELYQESITNPDKFFGNLAHELLTWDHDFTTVSSGGFEKG
DVAWFLEGRLNASYNCVDRHAAKNPDKVAIIYEADDTHESRNITYGELMAEVSRVANVLKSFGVGKGDSVAVYLPMIPEA
LIALLAISRLGAVHSVIFAGFSSGSIKDRINDAKSKVVITTDEGKRGGKTVLTKAIVDEGLKSCPSIEKVLVYKRTGGKV
PWVEGRDFWWDEEVAKQRPYCPPVPVSAEDPLFLLYTSGSTGSPKGVVHSTGGYLLGAAASSKYVFDIHPDDILFTCGDV
GWITGHTYAFYGPLLLGATTVIFEGTPVYPSYSRYWEIVEKYKVTQFYVAPTALRLLKRAGEDFIKKHDLSSIRTLGSVG
EPIAPDIWEWYNEHIGNKNCHISDTYWQTETGSHIIAPLAGVTPMKPGSATLPFFGIDLVIIDPVSGKEIEGNDVEGVLA
IRKPWPSIARTVYGDHQRYLETYLKPYPGYYFTGDGAGRDHEGYYWIRGRVDDVVNVSGHRLSTAEIEAALLAHKSVAES
AVVGVADELTGQAVIAFVSLKSGEPNDALKKELIMQVRKEIGPFSAPKAILIVEDLPKTRSGKIMRRILRKIVSGEADSI
GDVSTLSEPDVVEKIIESVGQQYNIPGKN

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019427 acetyl-CoA biosynthetic process from acetate

Molecular Function

GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
GO:0016208 AMP binding

Cellular Component

None predicted.