Protein

MCA_01507_1

Length
2,219 amino acids

Gene name: BRR2

Description: Pre-mRNA-splicing helicase BRR2

Browser: contigA:4663675-4670456+

RNA-seq: read pairs 1489, FPKM 8.3, percentile rank 22.9% (100% = highest expression)

Protein function

Annotation:BRR2Pre-mRNA-splicing helicase BRR2
KEGG:K12854SNRNP200 pre-mRNA-splicing helicase BRR2 [EC:3.6.4.13]
EGGNOG:0PGAGBRR2helicase
SGD closest match:S000000974BRR2Pre-mRNA-splicing helicase BRR2
CGD closest match:CAL0000181172orf19.3098ATP-dependent RNA helicase

Protein alignments

%idAln lengthE-value
MIA_02719_168.27%21970.0MIA_02719_1
A0A0J9XKE9_GEOCN60.86%22150.0Similar to Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase (DEIH box) OS=Geotrichum candidum GN=BN980_GECA23s00197g PE=4 SV=1
A0A060TE03_BLAAD54.85%22350.0ARAD1D03982p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D03982g PE=4 SV=1
UniRef50_A0A060TE0354.85%22350.0ARAD1D03982p n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A060TE03_BLAAD
A0A1E3PM47_9ASCO54.36%22150.0Sec63-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50185 PE=4 SV=1
A0A167FZE2_9ASCO59.15%20220.0Brr2p OS=Sugiyamaella lignohabitans GN=BRR2 PE=4 SV=1
Q6C0Y6_YARLI47.05%22170.0YALI0F20724p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20724g PE=4 SV=1
A0A1E4TCW3_9ASCO42.38%22320.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4197 PE=4 SV=1
BRR2_YEAST44.56%19390.0Pre-mRNA-splicing helicase BRR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BRR2 PE=1 SV=2
A0A1D8PMR5_CANAL40.87%21090.0ATP-dependent RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3098 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0017

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 500 1000 1500 2219

Detailed signature matches

  1. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  5. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. SSF46785 ("Winged h...)
  6. Domain IPR004179
    Sec63 domain
    1. SM00973 (Sec63_2)
    2. PF02889 (Sec63)
  7. Domain IPR000008
    C2 domain
    1. G3DSA:2.60.40...
  8. Domain IPR014756
    Immunoglobulin E-set
    1. SSF81296 (E set dom...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.15...
  3. G3DSA:1.10.33...
  4. G3DSA:3.40.50...
  5. PIRSF039073 (BRR2)
  6. SSF158702 (Sec63 N-...)
  7. cd00046 (DEXDc)
  8. cd00079 (HELICc)
  9. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...
  5. ATP binding site c...
  6. putative Mg++ bind...

Protein sequence

>MCA_01507_1
MTERDNSQYRYGEMSNKITRVDRRMISKASNDATGGLESLSGKISVKDLGTRVTRTSLKSDGIDKKNLKTEVSERHGLTS
GEPEASRPKKSSRKKGSSSVLKSSSFLDDAGLVEGLNYYPQTVETREAFDLIMAWVQAYLEDVPHETIRSAADAILSIIK
DENLIDKEQKSQVDEILGLVVPNDKYNQLINLTRRITDYSNSIEEHARQRDTKLEEDSGVAVTFDSEEEDEDLYGDSEDD
SESDDETNQQTAGTEDSDSEQIDDGEAEIIKPTESSSKSNKSASQMKASDQLKSKDTSDSIPAHEIDAYWLQRQVAEVYS
DAQEVQEKSTQIFEILASDSPLSKVENEIMEIFDFDHFELTKKLCKNREKVVWLTRLARSTDNEERNNIITAMKSNGLQS
LVEELQGVSQEDKESSAVKNQEDQDVEMIDDDRDGNVQSSLRPPKVIDIEALVFDQGHRLNTAGELRLPEGTTKSITRTY
EEYDIPPPVKATNTGPLVDITTLPPWARPAFEGTKSLNPVQSKVFSSAFNTDENLLLCAPTGAGKTNVALLTILETISHY
LDLDTNKIDLDAFKIVYISPLKALVQEQVREFSKKLKSYGINVAELTGDRNLTKQQIAETQMIVTTPEKWDVITRKSSDT
SYTNLVRLIIIDEIHLLHDERGPVLENIVARTIRREIATGESVRLVGLSATLPNYKDVARFLRVDFDKGLYFFDSSYRPT
PLAQAYIGITEKKAFKRYQAMNDACYDKVLQYAGQHQVIIFVHSRKETAKTARYLRDKAAEEGTLHKFLKSDSAATKLLT
AESESVSNSDLKDLLPTGFAIHHAGLSRADRTSSEDMFREGYAQVLVSTATLAWGVNLPAHTVIIKGTQIYSPEKGRWVE
LSPQDVLQMLGRAGRPGYDKSGDGVIITAHTELSYYMSLINASLPIESQMMSKLIDSLNAEVALGSINTLDDAVEWLGYT
YLYVRMLKSPQDYKIGQDYDNDKALIQKRRDIAHSALVNLHRNNLVRYDAKGGAVKTTELGRIASHFYISHTSMATYNDQ
LKPFLTNIEIFRIFAMSEEFKYIPVRQEEKLELSKLLERAPIPVKETVEEPAAKINILLQAYISRLKLEGFALMSDMVYI
TQSAGRLIRAMYEIALRKGWAALTKITLDLCKMVDHRLWLSNTPLRQFPDVPTDVIKRTEASQLPWSKYFELQDPAEVGQ
ALRLESRGALVYNLLQKFPRLSVQARFRPITPTLLRVELAITPDFTEWDRSILGTAQTYLLTVEDSDGEAILFSDYFVLR
ERYFESEDPHYVDFTVPITDPLPPNYFVSLTSEKWMHCETRIVLPFHKLSLPAKFPPHTPVYDMEPVLVSSLEPESYQSL
FSFKSFNKIQTQTFYALYSTNESVFIGASASNGKTVCGELSILRLLNQMEQSEEFSGNEKVVYIAPFQDQIDARCDDWKS
RFQSVIEDSDSRINKLTGELSADLKILERSFIVLATPTQWDLISRRWQRRRNVQNVALVIADDVHMLGDLNGQIYELILS
RMRFMATQLDKSLRIVALSASLSNGKDIGKWLGATSTTIFNFSPSVHELPLEVHLQSLNIPHHPSFMIALAHPVYKAIKS
SAGDGTSSTLIYVEDRKQCVSSSADLLRLAKPDSKSHNEDYFLLAQRSSIAPLLEKVEDANLKESLESGIGYLYPYMAAA
DKRIVTALFQKKAIQVLIATRDTCWTGPKAGLVIVMGTQLYEGREHRYIDYTIGEILQMIGHASENPNGNQALILTNSSK
RDYYRKFLSEALPIESHLPANLADAFITEVSEGIISSRNDCMGWLMYTYFFSRLSANPTFYDLADTSYDGINVYLSELVE
NTLTNLAEAKMVELDTESEDSVAPLNGAVIASYYNISYFTMQTLLLSLTAKTRIKGMLEIVSSATEYEVLPIRTHEEELL
IKIHNHLPYKMHKFSPYSSHFKTFVLLQAHISRLSLPIDLAADQLIVLSKIVSLLAACVDVLSGDGHLNATYAMDLSQMT
IQAIWSKDSPLKQIPYFTQEIIKRCNEHDINNVYDFLMIEDDDLRQEIVGIPETDPRMAKIANFVNKYPSIDLSYEFPES
EKEKEEKNTIVADTQASIIVSINREADDEEEEEGEGEKGPTLIDTTVESQHFPFPKIENWWLVIGEVESNQIYGIKRVPL
SRSQQQVVLPFTISTVGTHNLTVWCMCDSYFDADKEIEVKVEVLQNEEEEDDDDDEMEE

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.