Protein
MCA_01466_1
Length
374 amino acids
Gene name: DRE2
Description: Fe-S cluster assembly protein DRE2; Component of the cytosolic Fe-S protein assembly (CIA)
Browser: contigA:4546760-4547885+
RNA-seq: read pairs 7469, FPKM 246.1, percentile rank 90.3% (100% = highest expression)
Protein function
| Annotation: | DRE2 | Fe-S cluster assembly protein DRE2; Component of the cytosolic Fe-S protein assembly (CIA) | |
|---|---|---|---|
| EGGNOG: | 0PIMK | DRE2 | Component of the cytosolic iron-sulfur (Fe S) protein assembly machinery. Required for the maturation of extramitochondrial Fe S proteins (By similarity). Has anti- apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death, probably by tethering the pro- apoptotic factor tah18 in the cytoplasm in the absence of oxidative stress (By similarity) |
| SGD closest match: | S000001779 | DRE2 | Fe-S cluster assembly protein DRE2 |
| CGD closest match: | CAL0000199333 | DRE2 | Fe-S cluster assembly protein DRE2 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01736_1 | 51.06% | 376 | 2e-91 | MIA_01736_1 |
| A0A0J9XKJ8_GEOCN | 66.67% | 114 | 6e-43 | Fe-S cluster assembly protein DRE2 OS=Geotrichum candidum GN=DRE2 PE=3 SV=1 |
| UniRef50_A0A0J9XKJ8 | 66.67% | 114 | 1e-39 | Fe-S cluster assembly protein DRE2 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKJ8_GEOCN |
| A0A060TI70_BLAAD | 33.70% | 362 | 8e-42 | Fe-S cluster assembly protein DRE2 OS=Blastobotrys adeninivorans GN=DRE2 PE=3 SV=1 |
| A0A1E3PPC7_9ASCO | 54.89% | 133 | 7e-37 | Fe-S cluster assembly protein DRE2 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=DRE2 PE=3 SV=1 |
| A0A167G0E1_9ASCO | 65.22% | 115 | 3e-37 | Fe-S cluster assembly protein DRE2 OS=Sugiyamaella lignohabitans GN=DRE2 PE=3 SV=1 |
| DRE2_YARLI | 60.91% | 110 | 2e-37 | Fe-S cluster assembly protein DRE2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DRE2 PE=3 SV=1 |
| A0A1E4TDF5_9ASCO | 58.77% | 114 | 8e-34 | Fe-S cluster assembly protein DRE2 OS=Tortispora caseinolytica NRRL Y-17796 GN=DRE2 PE=3 SV=1 |
| DRE2_CANAL | 45.99% | 137 | 1e-27 | Fe-S cluster assembly protein DRE2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DRE2 PE=3 SV=1 |
| DRE2_YEAST | 67.27% | 55 | 2e-20 | Fe-S cluster assembly protein DRE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DRE2 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0497
Protein family membership
- Anamorsin (IPR007785)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
374
Detailed signature matches
-
-
PF16803 (DRE2_N)
-
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_01466_1 MTTDSISASPKESVLLLLTSEAVSDPKYVESVSKYFSNHNNVDIHRHVVDRVSSGAAKLASDKEAFFSKVYYLPMTASEN EAIFTLPNVLDFIFKALAPEGSLYTISLTQSTSDHPQSKTIEVTPTMITSAIVAGFLQSSDKTHFSKPKESIVAAAQTAT LLPRRQKQTATSSNTLTANNKVLLPMFKRKIAAEPSSPTSSTASLHSNEPTTPPSTNNISSSIVKLSLTDDIGDDDDDDG FLDENALLSNDFSSSFLSKPIVLPPKCDPGPGKRRRKACKDCSCGLREIEEAEEEQQRKKQNQVILNLDGGSNKSNSVFD DDYAIDFTVPGKPVGSCGSCALGDAFRCDGCPYLGLPPFKPGEIINISAIKNDL
GO term prediction
Biological Process
GO:0016226 iron-sulfur cluster assembly
Molecular Function
GO:0051536 iron-sulfur cluster binding
Cellular Component
GO:0005737 cytoplasm