MCA_01296_1

Protein

Length

660 amino acids

RNA-seq: read pairs 2877, FPKM 53.8, percentile rank 66.8% (100% = highest expression)

Protein function

EGGNOG:	0PJKR	PGUG_05418	transporter
SGD closest match:	S000001704	MCH2	Probable transporter MCH2
CGD closest match:	CAL0000197279	orf19.4337	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_01865_1	61.93%	436	2e-175	MIA_01865_1
UniRef50_J3K9L7	37.05%	413	3e-73	MFS transporter n=36 Tax=Eurotiomycetidae TaxID=451871 RepID=J3K9L7_COCIM
A0A1E3PRR6_9ASCO	35.57%	433	1e-74	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48771 PE=4 SV=1
Q6C0D7_YARLI	35.59%	413	1e-67	YALI0F25619p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25619g PE=4 SV=1
A0A0J9XJQ7_GEOCN	34.48%	435	1e-66	Similar to Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases OS=Geotrichum candidum GN=BN980_GECA20s00164g PE=4 SV=1
A0A1D8PNK9_CANAL	35.34%	399	2e-63	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4337 PE=4 SV=1
MCH2_YEAST	31.45%	442	3e-60	Probable transporter MCH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH2 PE=1 SV=2
A0A1E4TCK1_9ASCO	29.08%	368	2e-45	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32724 PE=4 SV=1
A0A060TFW4_BLAAD	28.77%	365	2e-33	ARAD1D17842p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17842g PE=4 SV=1
A0A167FRE1_9ASCO	28.88%	374	2e-24	Mch5p OS=Sugiyamaella lignohabitans GN=MCH5 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0031

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
216 - 617
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 600 660

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  238 - 564
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  216 - 617
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  234 - 612
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

298 - 303

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

351 - 361

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

554 - 564

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 231

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

491 - 501

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

611 - 660

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

414 - 433

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

422 - 638

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

227 - 421

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

383 - 393

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

522 - 526

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

460 - 470

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

585 - 589

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

264 - 274

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

324 - 328

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

329 - 351

TMHMM
TMhelix (TMhelix)

558 - 580

TMHMM
TMhelix (TMhelix)

523 - 545

TMHMM
TMhelix (TMhelix)

364 - 386

TMHMM
TMhelix (TMhelix)

396 - 413

TMHMM
TMhelix (TMhelix)

471 - 490

TMHMM
TMhelix (TMhelix)

233 - 255

TMHMM
TMhelix (TMhelix)

434 - 456

TMHMM
TMhelix (TMhelix)

590 - 609

TMHMM
TMhelix (TMhelix)

275 - 297

TMHMM
TMhelix (TMhelix)

302 - 324

TMHMM
TMhelix (TMhelix)

497 - 519

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

232 - 263

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

590 - 610

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

527 - 553

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

502 - 521

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

362 - 382

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

304 - 323

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

434 - 459

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

329 - 350

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

275 - 297

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

471 - 490

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

565 - 584

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

394 - 413

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 54

MobiDB Lite
mobidb-lite (disorder_prediction)

181 - 216

MobiDB Lite
mobidb-lite (disorder_prediction)

83 - 152

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

248W

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

251S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

252G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

253S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

255G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

256I

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

279G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

282Q

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

283F

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

286G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

290S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

291P

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

293I

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

294I

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

341L

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

342G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

345F

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

346I

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

349N

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

350A

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

353P

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

364N

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

365G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

368T

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

369S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

375S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

447T

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

450C

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

451Y

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

454V

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

455L

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

458M

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

472G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

476S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

480S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

483L

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

487R

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

535G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

538I

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

539S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

542S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

546P

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

547P

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

550A

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

561L

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

562L

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

565S

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

566W

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

570G

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

571A

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

574I

putative substrate translocation pore
248W, 251S, 252G, 253S, 255G, 256I, 279G, 282Q, 283F, 286G, 290S, 291P, 293I, 294I, 341L, 342G, 345F, 346I, 349N, 350A, 353P, 364N, 365G, 368T, 369S, 375S, 447T, 450C, 451Y, 454V, 455L, 458M, 472G, 476S, 480S, 483L, 487R, 535G, 538I, 539S, 542S, 546P, 547P, 550A, 561L, 562L, 565S, 566W, 570G, 571A, 574I
CDD
cd06174 (MFS)

Protein sequence

>MCA_01296_1
MPNHNHQESNETSFNISHEDYSSSSNSLNNTHNMHHTNHQLHQNHHHHSSNANQHIASDEITIPPNSGIAGGEIIWAEEE
AEITSDSNRYNDTKEKSPNTHINTGSSSKTTESQESGQAFSSNMIQKSSSKTSFPTIHENNTNGNINDTNENNKTNYQIT
LEENLYDNLGTCEKAENRNLYASDNDNNSNNNNNNNDNSNNNSNSNNNNNEKPQEEADILDSAGQIKFDRGYAWVVCLAG
TFINAFSWGASGSFGIFLATYLSSNMYPGATREDFAFVGGLQFGVGLMISPLIIYIVQYVRYSVVICVGACLQAAAYIAA
SYATEKWHLFLTQGVLSGIGLGTVFIPANAAIPQWFVKRRGVANGIFTSGAGLGSIIFSLSVQALIDKIGLRWAQRYVGF
FTLGACILCGLLVRERKEIPKKKLAAFKFSLLKLGYIWLVIIWGAITMFCYGIVLYTMAPFAVNIGLTHQQGSVLSAIFS
TGLIIGRPVLGHLADTIGSINAGMVSTLLSSLFILAWWIPANSYGSLIALNLILGSVISAFSVGFPPICASLVKLQDLSA
LLSMSWPIIGAINIFSTPTAIGLTKIDGTYLYSQILTGLLFFVSFLILLVTRGIRIRLAENIKLRDEKEESSETNMEISS
GDKPYKQEPFYKLMFKFTKL

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features