Protein

MCA_01294_1

Length
456 amino acids

Gene name: LYS21

Description: Homocitrate synthase, mitochondrial

Browser: contigA:4067605-4068976+

RNA-seq: read pairs 6878, FPKM 186.0, percentile rank 87.3% (100% = highest expression)

Protein function

Annotation:LYS21Homocitrate synthase, mitochondrial
KEGG:K01655LYS21 homocitrate synthase [EC:2.3.3.14]
EGGNOG:0PIJDFG03993.1homocitrate synthase
SGD closest match:S000002289LYS21Homocitrate synthase, mitochondrial
CGD closest match:CAL0000201759LYS22Lys22p

Protein alignments

%idAln lengthE-value
MIA_01869_192.38%4200.0MIA_01869_1
A0A167CWA7_9ASCO91.46%4100.0Homocitrate synthase LYS21 OS=Sugiyamaella lignohabitans GN=LYS21 PE=3 SV=1
A0A060T9Z1_BLAAD89.76%4200.0ARAD1D18854p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D18854g PE=3 SV=1
HOSM_YARLI86.82%4250.0Homocitrate synthase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LYS1 PE=3 SV=1
A0A0J9XBB5_GEOCN88.56%4110.0Similar to Saccharomyces cerevisiae YDL131W LYS21 Homocitrate synthase isozyme OS=Geotrichum candidum GN=BN980_GECA08s01176g PE=3 SV=1
Q59TC4_CANAL89.66%4060.0Lys22p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LYS22 PE=3 SV=1
A0A1E4TA63_9ASCO88.29%4100.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127326 PE=3 SV=1
A0A1E3PL79_9ASCO87.78%4090.0Homocitrate synthase mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82951 PE=3 SV=1
HOSM_YEAST85.01%4270.0Homocitrate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS21 PE=1 SV=1
UniRef50_G3ALA291.00%3890.0Homocitrate synthase n=33 Tax=Dikarya TaxID=451864 RepID=G3ALA2_SPAPN

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0142

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 456

Detailed signature matches

  1. Family IPR011872
    Homocitrate synthase, fungi/archaea
    1. TIGR02146
  2. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  3. Domain IPR000891
    Pyruvate carboxyltransferase
    1. PF00682 (HMGL-like)
    2. PS50991 (PYR_CT)
  4. SITE IPR002034
    Alpha-isopropylmalate/homocitrate synthase, conserved site
    1. PS00815 (AIPM_HOMOC...)
    2. PS00816 (AIPM_HOMOC...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF51569 (Aldolase)
  2. cd07948 (DRE_TIM_HCS)
  3. mobidb-lite (disord...)

Residue annotation

  1. catalytic residues...
  2. active site cd07948
  3. metal binding site...

Protein sequence

>MCA_01294_1
MTESSSSTAPAAEPSSGVESISSHVKSNPYGPNPSDFLSNVSSFKLIESTLREGEQFANAFFDTEKKIEIAKALDDFGVD
YIELTSPAASEQSLKDCEAICKLGLKAKILTHIRCHMDDARLAVATGVDGVDVVIGTSQFLRQYSHGKDMNYIAKSAIEV
IEYVKSHGIEIRFSSEDSFRSDLVDLLNIYRTVDKIGVNRVGIADTVGCANPRQVYDLVRTLKSIVSCEIECHFHNDTGC
AIANAYTALEAGATLIDVSVLGIGERNGITPLGGLMARMIAADRDYVLSKYKLHKLRDLEILVAEAVSVNIPFNNPITGF
CAFTHKAGIHAKAILANPSTYEILNPSDFGLSRYIHFANRLTGWNAIKSRVDQLNLNLTDAQCKEVTAKIKQLGDIRPLN
IDDVDSIIKDFHASANTPLLGPVADDEHVTKKLKIDEPIAEEAKPEAEAEAPAPSS

GO term prediction

Biological Process

GO:0019752 carboxylic acid metabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid

Molecular Function

GO:0003824 catalytic activity
GO:0004410 homocitrate synthase activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Cellular Component

None predicted.