Protein

MCA_01250_1

Length
1,085 amino acids

Gene name: MTR4

Description: ATP-dependent RNA helicase DOB1

Browser: contigA:3929141-3932399+

RNA-seq: read pairs 1723, FPKM 19.6, percentile rank 40.9% (100% = highest expression)

Protein function

Annotation:MTR4ATP-dependent RNA helicase DOB1
KEGG:K12598MTR4 ATP-dependent RNA helicase DOB1 [EC:3.6.4.13]
EGGNOG:0PHU2MTR4RNA helicase
SGD closest match:S000003586MTR4ATP-dependent RNA helicase DOB1
CGD closest match:CAL0000198236orf19.1335ATP-dependent RNA helicase

Protein alignments

%idAln lengthE-value
MIA_01766_178.83%9920.0MIA_01766_1
A0A0J9X6C1_GEOCN70.47%9990.0Similar to Saccharomyces cerevisiae YJL050W MTR4 ATP-dependent 3'-5' RNA helicase of the DExD/H family OS=Geotrichum candidum GN=BN980_GECA03s06247g PE=4 SV=1
A0A167CB28_9ASCO68.60%10000.0ATP-dependent RNA helicase MTR4 OS=Sugiyamaella lignohabitans GN=MTR4 PE=4 SV=1
A0A060T9Q5_BLAAD67.20%10000.0ARAD1D20438p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20438g PE=4 SV=1
A0A1E3PRF8_9ASCO66.36%9930.0Antiviral helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68269 PE=4 SV=1
MTR4_YEAST63.32%9950.0ATP-dependent RNA helicase DOB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MTR4 PE=1 SV=1
UniRef50_P4704763.32%9950.0ATP-dependent RNA helicase DOB1 n=213 Tax=Eukaryota TaxID=2759 RepID=MTR4_YEAST
Q6C9C9_YARLI63.18%9940.0YALI0D12210p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D12210g PE=4 SV=1
A0A1D8PRD5_CANAL59.44%9960.0ATP-dependent RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1335 PE=4 SV=1
A0A1E4T9N9_9ASCO59.78%9920.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_58742 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0326

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1000 1085

Detailed signature matches

  1. Family IPR016438
    ATP-dependent RNA helicase Ski2
    1. PIRSF005198 (SKI2)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. Domain IPR025696
    rRNA-processing arch domain
    1. PF13234 (rRNA_proc-...)
  7. Domain IPR012961
    ATP-dependent RNA helicase Ski2, C-terminal
    1. SM01142 (DSHCT_2)
    2. PF08148 (DSHCT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00046 (DEXDc)
  3. cd00079 (HELICc)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_01250_1
MDLFDVFDEEAPALDQETKQPSNVGDKRPRSSTSTDSEVEEIFPEKKDENNKSNNNTDNDTKSFEKAEESKSKNDNDKKK
SSKRMKKGLIGPGPKAVVTDSFETEASREVTASSGLLPQEATGEGEKNVVLSHQVRHQVALPPKYDYVPISKHVIKNPAK
TYPFTLDPFQQVSITSIDRNESVLVSAHTSAGKTVVAEYAIAQCLRDKQRVIYTSPIKALSNQKYRELLERFHDVGLMTG
DVTINPEASCLVMTTEILRSMLYRGSEVIREVAWVIFDEIHYMRDPERGVVWEETIILLPDKVHYVFLSATIPNAMQFAE
WVCKTHHQPCHVVYTNFRPTPLQHYLFPKGGNGIFLVVDEKSNFREDNFQKAMGILGNQMGEDPASADAKHKKGKIFKGG
KKELDDIYKIVRMVIQKSFNPVIVFSFSKRDCEQHALKLAKLNLNNEDEIAMVDKIFNNAMNSLSEEDRKLPQISHLLPL
LRRGIGVHHSGLLPILKEVIEILFQEGYIKVLFATETFSIGLNMPAKTVVFTNVRKYDGVNFRWVSGGEYIQMSGRAGRR
GLDDRGIVILMIDEQMEPTVAKGMVTGQADRLDSAFHLSYNMILNLLRVEGISPEFMLERCFFQYQNQDKIPELEKEYFE
VKEKISTITIDNEDDIKDYYETREQIEEFGKEIQTVITHPTHIVPYLQPGRLIHVKINGVDFDWGVIVSFDRRKTPKAAS
VVIEPHKTIVVEVLLWLTKASPVNLLRKKSPILHPGIMPSTDPNDGKMEAIWITLDSIAELGNLKVFLPKELTTVAQRNP
LKKNIEEIKRRFPDGIPRPDPVENMKIVDSSFLKTVRKIEVLETRLAQNPLCKSPELEEKYNEYANKVALIKKGKELKNK
LSKAYAVMQLDELRNRKNVLKQLEFITPDELVELKGRVACEISTGDELVITEMIFNGSFSTLTPEQCAALLSCFVFDEKT
REKPALVPELQIPYNSLLEVARRVGQVSKQCKLEIGDLDEYLGKFKMELMDVVFQWCKGASFAQICRMTDAYEGSLIRLF
RRLEELLMEVAEAAKIMGNNEIKEKMEKALGMIKRDMVSASSLYL

GO term prediction

Biological Process

GO:0006401 RNA catabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

Cellular Component

None predicted.