MCA_01241_1
Gene name: URA2
Description: Protein URA2
Browser: contigA:3897717-3904551+
RNA-seq: read pairs 6528, FPKM 35.4, percentile rank 57.4% (100% = highest expression)
Protein function
| Annotation: | URA2 | Protein URA2 | |
|---|---|---|---|
| KEGG: | K11541 | URA2 | carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2] |
| EGGNOG: | 0PFDZ | FG09638.1 | Bifunctional pyrimidine biosynthesis protein (PyrABCN) |
| SGD closest match: | S000003666 | URA2 | Protein URA2 |
| CGD closest match: | CAL0000196578 | URA2 | Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00294_1 | 83.38% | 2269 | 0.0 | MIA_00294_1 |
| A0A0J9X615_GEOCN | 77.22% | 2283 | 0.0 | Similar to Saccharomyces cerevisiae YJL130C URA2 Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) OS=Geotrichum candidum GN=BN980_GECA04s01220g PE=3 SV=1 |
| A0A167ETX0_9ASCO | 73.49% | 2282 | 0.0 | Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase OS=Sugiyamaella lignohabitans GN=URA2 PE=3 SV=1 |
| A0A1E3PEK1_9ASCO | 71.98% | 2277 | 0.0 | Carbamoyl-phosphate synth OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83947 PE=3 SV=1 |
| Q6C6H5_YARLI | 71.77% | 2271 | 0.0 | YALI0E09493p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E09493g PE=3 SV=1 |
| A0A060T6W0_BLAAD | 71.38% | 2278 | 0.0 | ARAD1B15246p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15246g PE=3 SV=1 |
| A0A1E4TB48_9ASCO | 69.31% | 2284 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32390 PE=3 SV=1 |
| UniRef50_Q75BK8 | 68.37% | 2292 | 0.0 | ACR263Cp n=46 Tax=Fungi TaxID=4751 RepID=Q75BK8_ASHGO |
| A0A1D8PTD1_CANAL | 68.64% | 2286 | 0.0 | Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA2 PE=3 SV=1 |
| PYR1_YEAST | 67.32% | 2289 | 0.0 | Protein URA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA2 PE=1 SV=5 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0522
Protein family membership
- Carbamoyl-phosphate synthase, small subunit (IPR006274)
- Carbamoyl-phosphate synthase, large subunit (IPR006275)
- Aspartate/ornithine carbamoyltransferase (IPR006130)
- Aspartate carbamoyltransferase (IPR002082)
Domains and repeats
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Domain
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Domain
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Domain
Detailed signature matches
no IPR
Residue annotation
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catalytic site cd0...
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subunit interface ...
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probable substrate...
Protein sequence
>MCA_01241_1 MSRFSLPIFPPLKPEHKLTSLELKDGNVVQGYSFGADTDAAGELVFQTGMVGYPESITDPSYQGQILVITFPLVGNYGVP SRTEMDELIPQLPKYFESNRIHVAGLVVASYTEDYSHYLATSSLGQWLKEEGIPAIYGVDTRALTKYIRTQGSSLARLLT IKSNTLDAQDLAKASSKDSWTPYFNSIPWSDPNTRNLVNEVSTKSPVLYKPTKNTLKDSQGNTIRILAVDVGMKYNQIRC FVNRGVELKVVPWDYDFSNEEYDGLFLSNGPGDPQTVKSVSEKLTPLLDPKNKKFVPIFGICLGHQLLAISSGASTHKLK FGNRGHNIPATNLISGRCYITSQNHGFAVDVETLSNGWKELFVNANDGSNEGIYHESLPLFSVQFHPESTPGPRDTEFLF DTFLQTVLEYKNSKTLKPVQFPGGTRAENDLKHPRVKVEKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINP NIATIQTSKGLADKVYFLPVTPDFVRKVIKYERPDAIYVTFGGQTALNVGIQLKDEFEELGVKVLGTQIDTIITTEDREL FARSMEEIGEKVAKSQTASSIQEALDAVEEIGFPVIVRAAYALGGLGSGFAENEEQLIALCNKAFAASPQVLVERSMKGW KEIEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSKE YCIIEVNARLSRSSALASKATGYPLAFIAAKLGLNIRLDEIKNTVTKVTSSCFEPSLDYIVVKIPRWDLKKFTRVSKELS SSMKSVGEVMSIGRTFEEAIQKAIRSTDYHNLGFNATDALMSIDIDTELQTPSDQRLFAIANALDSGYSVDKVWSMTKID KWFLNKLNGLVTFAQGLTKYTVSSLPVNLLREAKQLGFEDRQIAKFIGSTELKIRLLRVEAGVTPFVKQIDTVAAEFPAH TNYLYLTYNADSHDVDFNDHGVMVLGSGVYRIGSSVEFDWCAVRAVRTLREQGTKTIMVNYNPETVSTDYDEADRLYFEV INLERVLDIYDLENSSGVVVSMGGQTSNNIALTLHRQNVKILGTSPEMIDSAENRYKFSRMLDTIGVDQPAWKELTSYEE AEDFANKVGFPVLVRPSYVLSGAAMNTVYSRDDLKSYLEQAVEVSRDYPVVITKYIENAKEIEMDAVAKDGKLIMHVVSE HVENAGVHSGDATLIVPPQDLDPETVRRIVVATAKIGNALNVTGPYNIQFIAKDNEIKVIECNVRASRSFPFVSKVLGVD LIEMATKAIAGFDVQPYPLQDIPDDYVAIKVPQFSFSRLSGADPILGVEMASTGEVATFGHNKYEAYLKSLIATGFSMPK KNILLSIGSFKEKVELLPSVQKLHQLGYRLFATAGTADFIQEHGIPVQYLEDLNEANESGEKSEYSLTQHLANNLIDLYI NLPSNNRFRRPANYVSKGYRTRRMAVDYAVPLVTNVKNAKLLIEAIARNTSLDISSIDSQTSHRTITLPGLISIATFVPS LTTPNSRDLDRILKLSLASGFTMNRILPIASTGLITGASDLKIAQNNAKNHEYTDYNFSVAATENNASELSQVTSSVGSL VVPFNYIANNVNSVTTVSEHFASWPAYKPIVTDAKATSIASILLLASLHNRSIHITNVTNKQDIGLIALSKERGLKVTCD VSIYSLFFAREDHPDCISLPLKSDIQALWENIKIIDVFSIGALPARVALESGSKDIVGAGIPDALPLLFSAVSDGRLTVD DIVARLYTNPKRIFELHDQLSTTVEIDLDRISEAVKKANTFTFGSTINNKPLKGYVERVIFNGKTVALDGELTITEPVGR DYSSVLLPHVAALANADLGVITGTSNNLSSSSIDNVSSTPLAPMAQIGQKKNKRMSFSAGPLEDMKEFRGIKSPLLTRES LSTFRDDQSDTTSSPREINATATLTKPQQNQLLREPSPPSAIKEALRMSPFLRRHVLSVRQFSRNDLHLLFAMAQEMRMA VERVGSLDILKGRLLTTLFFEPSTRTASSFDAAMQRLGGKVVAVSTSTSSAKKGETLQDTIRTLACYSDAIVLRHPEESS ANIAGKFSPIPVINGGNGSVEHPTQAFLDLFTIREELGTVNGINVTFVGDLKYGRPVHSLCKLLQYYNVKITLVSPAELS LPETIVSDLKSTGHFEQQSEVLTDSIIASSDVIYCTRVQKERFADVADFERLKDTYIIDNKVLAKAKKHMCIMHPLPRNN EISEEVDFDNRAAYFRQMRYGLFVRMALLAMVIGAEI
GO term prediction
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006520 cellular amino acid metabolic process
GO:0006541 glutamine metabolic process
GO:0006807 nitrogen compound metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0004070 aspartate carbamoyltransferase activity
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016597 amino acid binding
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0046872 metal ion binding
Cellular Component
None predicted.