Protein

MCA_01188_1

Length
1,558 amino acids

Gene name: ROM2

Description: RHO1 GDP-GTP exchange protein 2

Browser: contigA:3762288-3767038+

RNA-seq: read pairs 2369, FPKM 18.8, percentile rank 39.8% (100% = highest expression)

Protein function

Annotation:ROM2RHO1 GDP-GTP exchange protein 2
KEGG:K19842ROM1_2 RHO1 GDP-GTP exchange protein 1/2
EGGNOG:0PFP7ROM2nucleotide exchange factor
SGD closest match:S000004363ROM2RHO1 GDP-GTP exchange protein 2
CGD closest match:CAL0000177920ROM2Rho family guanine nucleotide exchange factor

Protein alignments

%idAln lengthE-value
MIA_04908_169.86%9720.0MIA_04908_1
A0A060T202_BLAAD58.76%10960.0ARAD1C21076p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C21076g PE=4 SV=1
A0A0J9X8W4_GEOCN72.83%7840.0Similar to Saccharomyces cerevisiae YGR070W ROM1 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p OS=Geotrichum candidum GN=BN980_GECA05s04443g PE=4 SV=1
A0A167DC69_9ASCO62.28%9730.0Rho family guanine nucleotide exchange factor ROM2 OS=Sugiyamaella lignohabitans GN=ROM2 PE=4 SV=1
UniRef50_A0A167DC6962.28%9730.0Rho family guanine nucleotide exchange factor ROM2 n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A167DC69_9ASCO
A0A1E3PKG6_9ASCO63.40%7950.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_60047 PE=4 SV=1
A0A1E4TEF9_9ASCO59.14%7930.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26059 PE=4 SV=1
Q6CDY6_YARLI58.14%7860.0YALI0B20218p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B20218g PE=4 SV=1
Q5AH90_CANAL41.38%9740.0Rho family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ROM2 PE=4 SV=1
ROM2_YEAST41.16%9840.0RHO1 GDP-GTP exchange protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ROM2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0049

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1558

Detailed signature matches

  1. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. G3DSA:1.10.10.10
    2. SSF46785 ("Winged h...)
  2. Domain IPR000591
    DEP domain
    1. PF00610 (DEP)
    2. SM00049 (DEP_3)
    3. PS50186 (DEP)
  3. Domain IPR000219
    Dbl homology (DH) domain
    1. SSF48065 (DBL homol...)
    2. PF00621 (RhoGEF)
    3. PS50010 (DH_2)
    4. SM00325 (RhoGEF_3)
  4. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  5. Domain IPR001180
    Citron homology (CNH) domain
    1. SM00036 (nik_2)
    2. PS50219 (CNH)
    3. PF00780 (CNH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.90...
  2. PF15405 (PH_5)
  3. cd00160 (RhoGEF)
  4. cd04435 (DEP_fRom2)
  5. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...

Protein sequence

>MCA_01188_1
MNGNSSQDQRPPGLNERDAAFSDIFGLSRPPPGRKMEQSITRSPPSNDNQFILPNSPPSMPIQQGSRPYPPNMTSPQLNN
NNLQHPVRPNNGLQQKTSSPALSSNFQSQQDQFQLYDGPSPELKHDHRANTMDSNTIQQFHRDYKNNNNNNNNTNNSNNN
QRGAPPPLSQNREFHNINGNYPNQSFNDVGNPQYRPISPFTKSPPGQQQQQQQQQPNSRPNTESYPMNQQQMPPPNQSQQ
PYYYPQPHPGQVPNRPASAGPQAHSANRINNPNNRFPPSHPQQQFPQNQNQQPIPYPQQQRQPFPNAPIPPVASQRTASL
TSSSQYQAFSGQTPTPQQPRPHGAIPHKQQSLEQLPHSQRHGPNQPPFPNQQRSASAFTPINGGGGQLARPPINAYNQNV
KPESDLASSLRTMSLNSAAIRPHIHGTFDREPPNSQAKTLSGRVIPRKQTNELLPQATLQQTLKNVKSAKPGVLPLGGPT
AHQKGHRSSSTSSSGGGGEDGSAVPRIPFPHSTILTTSRRVPLVYPALLSKVAQVFRERINLGDKYKDGLTYTNAFTGSE
AVDLIAYIIKTTDRNLALLLGRALDAQKFFHDVTYEHRLRDKPDEFYQFNESLIQDTRDYDGGGSNGFNNNNNAMFERVP
SSSSIPYAHGSVGSSMSTLAENPKMPGTPNAVGTLTVGNQTSNSRAGSSSGKKTISAPIPVNGVFAILTNCYSPTCTRDQ
LCYSIACPRRLEQQARLNMKPNPVLKRAESRLSLHGDDEKEQKLWIHTVPKSIADSVSDKEKKRQEVICELIYTERDFVK
DLEYIRDFWIKPLMASNIIPESRREYVVKQIFGVINDVHAVNVKLADALTKRQMQSPIVWQVGDIFLEHVPKFKPFVQYG
KKQVYAKYEFERERAANPAFAKFVDDTERLKESRKLELNGYLTKPTTRLARYPLLLDAILKSTEDSNPDKQNLPKARLLI
REYLTEVNIESGKSENRLQLKQLDQSIRFRPNEKVDLKLTAENRQIIFKGMFKKENQGDVQVYLLDNCILFLRPKTVNKH
ETLTVYKAPIPLELLTISESDEPPQKGSSRRTSSSIISTAAKVGPLRENSQHKYPITFQYLGRRGYDLLLYASTFIGRKK
LVEHITQQKKALVEKNNVFTEHILMQRFFDSSNKVNCVTPLDGGRKLLYGTENGIWISDTKASNDGARRTTTAPQKIINI
GSVMQIDVMEEYNTLLALSEKTLYTWPLDCLDTLDPIGNERKARKVMGHINFYKVGICLGRILVCVAKNGSSSSTIRVLE
PIDPTPKGKRPPLRKILQVQNEGLKIFKECTVGSEIISISFLTSKLCVGCSKGFQVVSLQTNEIQSLLDPADTSLDFVVR
KEALKPIAIYRLHGDFLLNYSDFSFFVDRNGWRSRSDWIIHWEGSNPHGFALSYPYVIAFESNFVEIRHMETAELVRVIR
GENIRFLHENTREIMFAYEDEQKCDVVASLDFWEKSKVTTSNEKTSSTNTITEDQNNHQQQNPSNQSQQQQNQTARQHHH
SQQQQQPTKNSPKSPQKTHRHNTSATNEALSSFSFSPK

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction

Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity

Cellular Component

None predicted.