Protein

MCA_01151_1

Length
503 amino acids

Gene name: LAG1B

Description: Sphingosine N-acyltransferase LAG1

Browser: contigA:3651717-3653468-

RNA-seq: read pairs 3088, FPKM 75.7, percentile rank 74.2% (100% = highest expression)

Protein function

Annotation:LAG1BSphingosine N-acyltransferase LAG1
KEGG:K04709LAG1 Acyl-CoA-dependent ceramide synthase [EC:2.3.1.24]
EGGNOG:0PFRALAG1Longevity-assurance protein
SGD closest match:S000001491LAC1Sphingosine N-acyltransferase LAC1
CGD closest match:CAL0000190688LAC1Lac1p

Protein alignments

%idAln lengthE-value
MIA_00406_157.81%3201e-127MIA_00406_1
A0A060T784_BLAAD47.94%3157e-98ARAD1B21472p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21472g PE=4 SV=1
A0A167CI24_9ASCO44.13%3155e-96Sphingosine N-acyltransferase LAG1 OS=Sugiyamaella lignohabitans GN=LAG1 PE=4 SV=1
UniRef50_A0A167CI2444.13%3151e-92Sphingosine N-acyltransferase LAG1 n=2 Tax=Trichomonascaceae TaxID=410830 RepID=A0A167CI24_9ASCO
F2Z5Z1_YARLI47.04%3213e-95YALI0D04026p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04026g PE=4 SV=1
A0A0J9XAI5_GEOCN50.70%2842e-94Similar to Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component OS=Geotrichum candidum GN=BN980_GECA07s02111g PE=4 SV=1
A0A1E3PPQ1_9ASCO46.08%3191e-84Longevity assurance proteins LAG1/LAC1 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_5022 PE=4 SV=1
A0A1D8PKA5_CANAL41.59%3152e-73Lac1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LAC1 PE=4 SV=1
A0A1E4TBF5_9ASCO41.28%2814e-62Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133693 PE=4 SV=1
LAC1_YEAST29.80%3025e-30Sphingosine N-acyltransferase LAC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAC1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0033

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 503

Detailed signature matches

  1. Family IPR016439
    Ceramide synthase component Lag1/Lac1
    1. PIRSF005225 (LAG1_LAC1)
  2. Domain IPR013599
    TRAM1-like protein
    1. PF08390 (TRAM1)
  3. Domain IPR006634
    TRAM/LAG1/CLN8 homology domain
    1. PS50922 (TLC)
    2. PF03798 (TRAM_LAG1_...)
    3. SM00724 (lag1_27)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_01151_1
MAAVDLLPPHNEPNNYEDSSPSSLLVNRDSYSLISDDDDDDEESFQQIDTAGSSSIETSPNSRLSTSSSASSTTESLPIY
SEDTTTPSLKKNGGVVKPSSTSTIQSSSPSSPSTTTTPPPQSQQIKPLSISSLKTTKKSIKKKRDSGIAHYIHQRQLKIT
FFILSSILLTHFTSPTLSKYTTKCLKIQYIDPNTNLAQIGLDDAYFVGFWLVVLTFLRSLFVDNLLLLLGAHVFHIRGPK
KLLRFSEQLYADISYATFCFVGLRLMVNTPYWLSVKDLWIGWPHYLLDPYFKAYYLIEFAAWIQQIYVINIEERRKDHYQ
MFVHHIITCSLMFGSYYYYFTRVGNVILVLMDFVDIFLCSAKVLRYVGFQKVCDAFFVLFLASWLALRHGLYNFITYSAL
TDASSLLSGVCAYDEQTNAEIRCFSPTAYWCLIGLLVALQIITIGWLFMIIRVLIKVLSGNAAEDSRSDEEDDDEEEEEE
VIENEEKIKNQPLKLDNPIKLTG

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane